当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Analysis of graft-versus-host disease (GVHD) and graft rejection using MHC class I-deficient mice.

Analysis of graft-versus-host disease (GVHD) and graft rejection using MHC class I-deficient mice.

Abstract：

:GVHD is a major complication in allogeneic bone marrow transplantation (BMT). MHC class I mismatching increases GVHD, but in MHC-matched BMT minor histocompatibility antigens (mH) presented by MHC class I result in significant GVHD. To examine the modification of GVHD in the absence of cell surface MHC class I molecules, beta2-microglobulin-deficient mice (beta2m(-/-)) were used as allogeneic BMT recipients in MHC- and mH-mismatched transplants. Beta2m(-/-) mice accepted MHC class I-expressing BM grafts and developed significant GVHD. MHC (H-2)-mismatched recipients developed acute lethal GVHD. In contrast, animals transplanted across mH barriers developed indolent chronic disease that was eventually fatal. Engrafted splenic T cells in all beta2m(-/-) recipients were predominantly CD3+alphabetaTCR+CD4+ cells (15-20% of all splenocytes). In contrast, CD8+ cells engrafted in very small numbers (1-5%) irrespective of the degree of MHC mismatching. T cells proliferated against recipient strain antigens and recognized recipient strain targets in cytolytic assays. Cytolysis was blocked by anti-MHC class II but not anti-CD8 or anti-MHC class I monoclonal antibodies (MoAbs). Cytolytic CD4+ T cells induced and maintained GVHD in mH-mismatched beta2m(-/-) mice, supporting endogenous mH presentation solely by MHC class II. Conversely, haematopoietic beta2m(-/-) cells were unable to engraft in normal MHC-matched recipients, presumably due to natural killer (NK)-mediated rejection of class I-negative cells. Donor-derived lymphokine-activated killer cells (LAK) were unable to overcome graft rejection (GR) and support engraftment.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Shenoy S,Desch K,Duffy B,Thorson P,Mohanakumar T

doi

10.1046/j.1365-2249.1998.00578.x

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

188-95

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

112

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

    abstract：:Loss of pancreatic beta-cells in type I diabetes is associated with an increase in T helper 1 (Th1) proinflammatory cytokines in the islet milieu, with a concomitant reduction in Th2 anti-inflammatory cytokines. In animal models, manoeuvres designed to polarize Th1 responses towards Th2, particularly involving interle...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03375.x

    authors： Kaminski A,Kaminski ER,Morgan NG

    更新日期：2007-06-01 00:00:00

  • Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.

    abstract：:The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb03334.x

    authors： MacDonald TT,Hutchings P,Choy MY,Murch S,Cooke A

    更新日期：1990-08-01 00:00:00

  • Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.

    abstract：:Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably initiated by environmental factors, this disease takes place in genetically predisposed indivi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.12019

    authors： Barcala Tabarrozzi AE,Castro CN,Dewey RA,Sogayar MC,Labriola L,Perone MJ

    更新日期：2013-02-01 00:00:00

  • IgM levels and IgM-mediated immune responses in patients with acute hepatitis A, acute hepatitis B and chronic HB antigenaemia.

    abstract：:Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dietz WH Jr,Porcell O,Moon TE,Peters CJ,Purcell RH

    更新日期：1976-01-01 00:00:00

  • Amelioration of lupus manifestations by a peptide based on the complementarity determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patient

    abstract：:A peptide based on the complementarity determining region (CDR)1 of a human monoclonal anti-DNA autoantibody (hCDR1) was shown to either prevent or treat an already established murine lupus in systemic lupus erythematosus (SLE)-prone mice or in mice with induced experimental SLE. The present study was undertaken to de...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02559.x

    authors： Mauermann N,Sthoeger Z,Zinger H,Mozes E

    更新日期：2004-09-01 00:00:00

  • Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.

    abstract：:To clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2012.04646.x

    authors： Arakawa Y,Watanabe M,Inoue N,Sarumaru M,Hidaka Y,Iwatani Y

    更新日期：2012-11-01 00:00:00

  • What does the future hold for clinical studies in vasculitis?

    abstract：:The era prior to 1990 was a time of careful observation of disease presentation, course, outcomes and meticulous pathology studies. These mainly single-centre studies introduced new life-saving therapies for drugs still used effectively today. In the 1970-1980s, cyclophosphamide (CyP) added to glucocorticosteroids (GC...

    journal_title：Clinical and experimental immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1111/j.1365-2249.2011.04365.x

    authors： Hoffman GS

    更新日期：2011-05-01 00:00:00

  • Enhancement of the lytic activity of cloned human CD8 tumour-infiltrating lymphocytes by bispecific monoclonal antibodies.

    abstract：:We have isolated tumour-infiltrating lymphocytes (TIL) clones from a patient with renal cell cancer. The cloning frequency and the effector function were measured. No difference in cloning frequency (r2 = 0.97, frequency = 1:13) was observed between TIL expanded with allogeneic versus autologous feeder cells. Sixty-fo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06422.x

    authors： Gorter A,Krüse KM,Schrier PI,Fleuren GJ,van de Griend RJ

    更新日期：1992-01-01 00:00:00

  • Lymphocytotoxins and mixed leucocyte culture blocking factor activity in the plasma of uraemic patients undergoing haemodialysis.

    abstract：:Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfu...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Sengar DP,Rashid A,Perelmutter L,Harris JE

    更新日期：1975-05-01 00:00:00

  • Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction.

    abstract：:The lymphokine profiles were determined in the skin lesions of the three distinct clinical forms of American cutaneous leishmaniasis (ACL), using a reverse transcriptase polymerase chain reaction (RT-PCR) and primers for various lymphokines. The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TN...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb05931.x

    authors： Cáceres-Dittmar G,Tapia FJ,Sánchez MA,Yamamura M,Uyemura K,Modlin RL,Bloom BR,Convit J

    更新日期：1993-03-01 00:00:00

  • CD56(+dim) and CD56(+bright) cell activation and apoptosis in hepatitis C virus infection.

    abstract：:CD3- CD56(+dim) natural killer (NK) cells, which are cytotoxic against virally infected cells, may be important in hepatitis C virus (HCV)-infected patients who are successfully treated with pegylated interferon (PEG-IFN)-alpha. We used flow cytometry to enumerate activated (CD69+) and apoptotic (annexin-V+) dim (CD3-...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02523.x

    authors： Lin AW,Gonzalez SA,Cunningham-Rundles S,Dorante G,Marshall S,Tignor A,Ha C,Jacobson IM,Talal AH

    更新日期：2004-08-01 00:00:00

  • A controlled trial of treatment of acquired immunodeficiency in severe measles with thymic humoral factor.

    abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

    更新日期：1984-06-01 00:00:00

  • Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures.

    abstract：:The presence of transforming growth factor-beta (TGF-beta) in inflammatory joint disease was investigated. Synovial fluid from patients with rheumatoid arthritis (RA) and patients with other non-autoimmune inflammatory joint diseases contained high levels of both active and latent TGF-beta. Levels of active TGF-beta d...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb03331.x

    authors： Brennan FM,Chantry D,Turner M,Foxwell B,Maini R,Feldmann M

    更新日期：1990-08-01 00:00:00

  • Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats.

    abstract：:The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or alpha M beta 2 (complement receptor type 3 = CR3). In the present study...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb08363.x

    authors： Palmen MJ,Dijkstra CD,van der Ende MB,Peña AS,van Rees EP

    更新日期：1995-08-01 00:00:00

  • Late diagnosis of chronic granulomatous disease.

    abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13474

    authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

    更新日期：2020-09-01 00:00:00

  • Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation.

    abstract：:There are lines of evidence that natural killer (NK) cells are sensitive to physical and psychological stress. Alterations in the immune system including NK cells are known to differ among tissues and organs. The effect of stress on the lung immune system, however, has not been well documented in spite of the fact tha...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2005.02672.x

    authors： Kanemi O,Zhang X,Sakamoto Y,Ebina M,Nagatomi R

    更新日期：2005-01-01 00:00:00

  • MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells.

    abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12624

    authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

    更新日期：2015-07-01 00:00:00

  • Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1.

    abstract：:Using a sensitive IL-1-dependent T cell clone we estimated interleukin 1 (IL-1)-like activity in a variety of synovial fluids (SF). Although we demonstrate that SF contains potent inhibitors of endogenous and exogenous IL-1 we were able to estimate that samples from rheumatoid arthritis, osteoarthritis and other arthr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Hopkins SJ,Humphreys M,Jayson MI

    更新日期：1988-06-01 00:00:00

  • Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1.

    abstract：:Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb08351.x

    authors： Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

    更新日期：1995-08-01 00:00:00

  • A serologic study of cultured breast cancer cell lines: lack of antibody response to tumour specific membrane antigens in patients.

    abstract：:Humoral antibodies to tumour associated membrane antigens of cultured human breast cancer cell lines were studied using the immune adherence (IA) test. Sera from 353 post-operative breast cancer patients and from twenty-five patients immunized by allogeneic breast cancer cells were tested against the MDA-MB-436 cell l...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Higuchi M,Robinson DS,Cailleau R,Irie RF,Morton DL

    更新日期：1980-01-01 00:00:00

  • Incidence of selective IgG2 deficiency in patients with vasculitis.

    abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Jiménez A,López-Trascasa M,Fontán G

    更新日期：1989-11-01 00:00:00

  • Anti-oxidized low-density lipoprotein antibodies in myeloperoxidase-positive vasculitis patients preferentially recognize hypochlorite-modified low density lipoproteins.

    abstract：:Many patients surviving vasculitis are prone to accelerated atherosclerosis and often have enhanced levels of antibodies to oxidized low-density lipoprotein (oxLDL). To measure anti-oxLDL antibodies, oxidation of LDL is achieved with copper (Cu) or malondialdehyde (MDA). Because, in vivo, LDL may be oxidized with myel...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03420.x

    authors： Slot MC,Theunissen R,van Paassen P,Damoiseaux JG,Tervaert JW,Limburg Nephrology Working Group.

    更新日期：2007-08-01 00:00:00

  • IgG2 subclass restriction of antibody to pneumococcal polysaccharides.

    abstract：:Studies in experimental animals suggest that antibody responses to certain polysaccharide antigens may be restricted in IgG subclass distribution. To determine if human antibodies to pneumococcal polysaccharides are similarly restricted we measured the IgG subclass specific response to immunization with purified polyv...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Barrett DJ,Ayoub EM

    更新日期：1986-01-01 00:00:00

  • Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES.

    abstract：:Recently we showed the in vivo relevance of chemokines in cases of bacterial peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. Mesothelial cells, the most numerous cells in the peritoneal cavity, are hypothesized to function as a main source of chemokine production. We investigated the time- an...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00592.x

    authors： Visser CE,Tekstra J,Brouwer-Steenbergen JJ,Tuk CW,Boorsma DM,Sampat-Sardjoepersad SC,Meijer S,Krediet RT,Beelen RH

    更新日期：1998-05-01 00:00:00

  • LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-α stimulation.

    abstract：:This study examined the expression of the inhibitory receptor, leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its potential role in the modulation of inflammatory cytokines, matrix metalloproteinases (MMPs) an...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13100

    authors： Zhang Y,Wang S,Dong H,Yi X,Zhang J,Liu X,Zhuang R,Ding Y

    更新日期：2018-05-01 00:00:00

  • Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.

    abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01712.x

    authors： Hansson AS,Lu S,Holmdahl R

    更新日期：2002-01-01 00:00:00

  • Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-assocated markers of immune dysfunction.

    abstract：:We used three-colour cytometry to analyse intracellular cytokine production in activated whole blood cultures derived from patients with HIV-1 infection. We assessed mitogen-induced IL-2, IL-4 and IFN-gamma production from T cells as possible markers of immune dysfunction. The percentages of T cells staining for IL-2 ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00505.x

    authors： Westby M,Marriott JB,Guckian M,Cookson S,Hay P,Dalgleish AG

    更新日期：1998-02-01 00:00:00

  • Phagocytic efficacy of macrophage-like cells as a function of cell cycle and Fcgamma receptors (FcgammaR) and complement receptor (CR)3 expression.

    abstract：:Previous studies have shown that the efficiency of phagocytosis is a function of cell cycle and that phagocytosis promotes cell cycle progression. Because phagocytosis is dependent on cellular receptors we hypothesized that Fcgamma receptors (FcgammaR) and complement receptors (CR) expression varied with cell cycle. C...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03132.x

    authors： Luo Y,Cook E,Fries BC,Casadevall A

    更新日期：2006-08-01 00:00:00

  • Antibody penetration into living cells. IV. Different effects of anti-native DNA and anti-ribonucleoprotein IgG on the cell cycle of activated T gamma cells.

    abstract：:Normal T cells bearing receptors for the Fc portion of IgG that were incubated in anti-RNP or anti-DNA at the time of activation with phytohaemagglutinin showed different effects on this activation as determined by flow cytometric analysis of acridine orange stained cells. Incubation in anti-RNP caused an arrest in th...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Alarcón-Segovia D,Llorente L

    更新日期：1983-05-01 00:00:00

  • Functional studies on T cells in adult human bone marrow.

    abstract：:Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). Th...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： De Gast GC,Platts-Mills TA

    更新日期：1979-10-01 00:00:00