Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation.

abstract：:Biologically significant levels of IL-2 activity were produced by isolated lamina propria mononuclear cells (LPMC) from normal intestine (n = 12), cancer-bearing colons (n = 35) and inflammatory bowel disease (IBD) affected tissue (n = 12). The levels of IL-2 produced were similar for all three sources of LPMC (normal...

journal_title：Clinical and experimental immunology

authors： Pullman WE,Doe WF

更新日期：1992-04-01 00:00:00

abstract：:The spontaneous lysis of target cells sensitive to natural killer (NK) activity is accomplished in two distinct phases: (i) binding between target and effector cells and (ii) post-binding events leading to target cell destruction. To test the hypothesis that cell surface carbohydrate(s) might be involved in recognitiv...

journal_title：Clinical and experimental immunology

authors： Vose BM,Harding M,White W,Moore M,Gallagher J

更新日期：1983-03-01 00:00:00

abstract：:The functional integrity of the local immune system in vitamin A-deficient (A-) rats was investigated. Secretory IgA levels in the intestinal fluid of A- rats were significantly lower than in controls. This and the decrease in intensity of immunofluorescent staining for secretory component (SC) in the intestinal cells...

journal_title：Clinical and experimental immunology

authors： Sirisinha S,Darip MD,Moongkarndi P,Ongsakul M,Lamb AJ

更新日期：1980-04-01 00:00:00

abstract：:Female Hartley guinea-pigs were immunized with N-phthaloylated ox insulin (96% NA1,NB1,NB29-triphthaloyl ox insulin) using H. pertussis as adjuvant. Haptenic antibody, which was found in antisera taken 20 days after secondary immunization, was assessed for cross-reaction with a series of N-acylated ox insulins. Cross-...

journal_title：Clinical and experimental immunology

authors： Hollins PJ,Nathan MM

更新日期：1978-03-01 00:00:00

abstract：:Autoantibodies in the sera of patients with Goodpasture's syndrome showed a strong reaction in indirect immunofluorescence tests on unfixed, frozen sections of a mouse tumour (EHS sarcoma), previously shown to produce extracellular basement membrane. Anti-basement membrane antibodies from patients with bullous pemphig...

journal_title：Clinical and experimental immunology

authors： Wick G,Timpl R

更新日期：1980-03-01 00:00:00

abstract：:The present study demonstrates that tumour necrosis factor (TNF) and FMLP, but not IL-1 or IL-8, enhanced the adherence of polymorphonuclear neutrophil (PMN) to fibronectin, an extracellular matrix protein. The adherence induced by FMLP was very rapid, within 5 min while the induction of adherence by TNF was much slow...

journal_title：Clinical and experimental immunology

authors： Thompson HL,Matsushima K

更新日期：1992-11-01 00:00:00

abstract：:More than 11 genetic causes of severe combined immunodeficiency (SCID) have been identified, affecting development and/or function of T lymphocytes, and sometimes B lymphocytes and natural killer (NK) cells. Deletion of 22q11.2 is associated with immunodeficiency, although less than 1% of cases are associated with T-B...

journal_title：Clinical and experimental immunology

authors： Gennery AR,Slatter MA,Rice J,Hoefsloot LH,Barge D,McLean-Tooke A,Montgomery T,Goodship JA,Burt AD,Flood TJ,Abinun M,Cant AJ,Johnson D

更新日期：2008-07-01 00:00:00

abstract：:Intraperitoneal infection of mice with mycobacteria induces the persistent mobilization of neutrophils to the infected peritoneal cavities. The recruitment of the neutrophils was mediated by the immune system since it was enhanced by immunization and reduced in T cell-deficient nude and SCID mice. Anti-mitotic treatme...

journal_title：Clinical and experimental immunology

authors： Appelberg R

更新日期：1992-07-01 00:00:00

abstract：:The anti-schistosomular humoral responses of guinea-pigs vaccinated with radiation-attenuated cercariae of Schistosoma mansoni have been investigated in vitro. The sera of vaccinated animals contain schistosomulicidal complement-fixing antibodies which peak in titre at week 5 after vaccination and predominantly consis...

journal_title：Clinical and experimental immunology

authors： Gordon JR,McLaren DJ

更新日期：1987-02-01 00:00:00

abstract：:To clarify the differential state of B cell activation in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we investigated the expression of low-affinity receptor for IgE (Fc epsilon RII; CD23) on their peripheral B cells by a cytofluorometry using H107 (CD23) and Leu-16 (CD20) monoclona...

journal_title：Clinical and experimental immunology

authors： Kumagai S,Ishida H,Iwai K,Tsubata T,Umehara H,Ozaki S,Suginoshita T,Araya S,Imura H

更新日期：1989-12-01 00:00:00

abstract：:In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti-apoptotic B cell lymphoma (BCL-2) and BCL-XL associated with a diminished turnover. Azathioprine (AZA) directly targets BCL-2 family-mediated apoptosis. We investigate...

journal_title：Clinical and experimental immunology

authors： Weder B,Mozaffari M,Biedermann L,Mamie C,Moncsek A,Wang L,Clarke SH,Rogler G,McRae BL,Graff CL,Ruiz PA,Hausmann M

更新日期：2018-09-01 00:00:00

abstract：:A T helper (Th) 1 immune response is important for host defense against tuberculosis. The multidrug resistance protein (Mrp) 1 is constitutively present at low levels on Th2 lymphocytes, and is expressed on Th1 lymphocytes upon activation. To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficie...

journal_title：Clinical and experimental immunology

authors： Verbon A,Leemans JC,Weijer S,Florquin S,Van Der Poll T

更新日期：2002-10-01 00:00:00

abstract：:One hundred and sixty-two unrelated, healthy normals and 118 unrelated SLE patients were subdivided by sex, race, and disease, and each group was in Hardy-Weinberg equilibrium for autosomal codominant expression of the four CR1 alleles. There were no significant phenotypic differences between males and females (P grea...

journal_title：Clinical and experimental immunology

authors： Van Dyne S,Holers VM,Lublin DM,Atkinson JP

更新日期：1987-06-01 00:00:00

abstract：:The hypothesis that a virus might in some way be involved in the causation of type 1 diabetes has a long history, but decades of research have failed to resolve the issue beyond reasonable doubt. Viruses could potentially play a primary role in the pathogenesis of type 1 diabetes by initiating autoimmunity, a secondar...

journal_title：Clinical and experimental immunology

authors： Gale EA

更新日期：2012-04-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency disease, characterized by low levels of circulating immunoglobulins and recurrent bacterial infections, particularly of the respiratory tract. T cell dysfunction is often present, and lymphoproliferative and autoimmune di...

journal_title：Clinical and experimental immunology

authors： Holm AM,Tjønnfjord G,Yndestad A,Beiske K,Müller F,Aukrust P,Frøland SS

更新日期：2006-06-01 00:00:00

abstract：:Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...

journal_title：Clinical and experimental immunology

authors： Cai M,Zhou T,Wang X,Shang M,Zhang Y,Luo M,Xu C,Yuan W

更新日期：2016-03-01 00:00:00

abstract：:Spleens of BALB/c mice with plasmacytoma contain macrophages (M phi) which were found to suppress the in vitro immune function of normal splenic cells through a diffusible factor. The suppressor activity of these macrophages was reversibly inhibited by ligands specific for the corresponding PC globulin, but not by ant...

journal_title：Clinical and experimental immunology

authors： Chen YH,Heller P

更新日期：1982-11-01 00:00:00

abstract：:Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...

journal_title：Clinical and experimental immunology

authors： van Haelst PL,Tervaert JW,Bijzet J,Baljé-Volkers C,May JF,Langeveld B,Gans RO

更新日期：2004-11-01 00:00:00

abstract：:The distribution and regulatory function of immunoglobulin (Ig) synthesis by monocytes were assessed using several monoclonal antibodies and a cell sorter in samples from 13 patients with multiple myeloma (MM) and nine patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly w...

journal_title：Clinical and experimental immunology

authors： Takeshita A

更新日期：1986-12-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Compared to normal children, pre-natally infected infants had significantly elevated IgM concentrations throughout the first year of life and elevated IgA levels for the first 6 months. In contrast, IgG levels dropped significantly below normal at 3 months post-partum. Infants born without overt disease but with eleva...

journal_title：Clinical and experimental immunology

authors： McMurray DN,Rey H

更新日期：1981-05-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:The objective of the study was to determine the diagnostic value for rheumatoid arthritis (RA) of anti-filaggrin autoantibodies (autoAb) recognizing citrullinated recombinant rat filaggrin (ACRF) in community cases of very early arthritis. To evaluate the diagnostic value of ACRF, were studied sera from patients with ...

journal_title：Clinical and experimental immunology

authors： Vittecoq O,Incaurgarat B,Jouen-Beades F,Legoedec J,Letourneur O,Rolland D,Gervasi G,Ménard JF,Gayet A,Fardellone P,Daragon A,Jolivet M,le Loët X,Tron F

更新日期：2004-01-01 00:00:00

abstract：:Booster immunization of normal individuals with soluble tetanus toxoid (TT) produced significant levels of plasma anti-tetanus IgG and IgM detectable by an enzyme linked immunosorbent assay (ELISA). Similar changes in circulating anti-TT antibody were found in mice following primary immunization. There was. however, n...

journal_title：Clinical and experimental immunology

authors： Ershler WB,Moore AL,Hacker MP

更新日期：1982-09-01 00:00:00

abstract：:Nitric oxide (NO) is a mediator of inflammatory injury which is inhibited by glucocorticoids and is implicated in rheumatoid (RA) and adjuvant arthritis (AA). The glucocorticoid-induced anti-inflammatory molecule lipocortin 1 is expressed in RA synovium, but the effects of lipocortin 1 on synovial inflammation have be...

journal_title：Clinical and experimental immunology

authors： Yang YH,Hutchinson P,Santos LL,Morand EF

更新日期：1998-01-01 00:00:00

abstract：:In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins an...

journal_title：Clinical and experimental immunology

authors： Stevens WJ,Peetermans ME,Van Acker KJ

更新日期：1979-06-01 00:00:00

abstract：:We have isolated tumour-infiltrating lymphocytes (TIL) clones from a patient with renal cell cancer. The cloning frequency and the effector function were measured. No difference in cloning frequency (r2 = 0.97, frequency = 1:13) was observed between TIL expanded with allogeneic versus autologous feeder cells. Sixty-fo...

journal_title：Clinical and experimental immunology

authors： Gorter A,Krüse KM,Schrier PI,Fleuren GJ,van de Griend RJ

更新日期：1992-01-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

journal_title：Clinical and experimental immunology

authors： Hellesen A,Bratland E

更新日期：2019-01-01 00:00:00

abstract：:C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation. Attempts to demonstrate changes in C4BP plasma levels in systemic lupus erythematosus and essential mixed cryoglobulinaemia have failed, probably du...

journal_title：Clinical and experimental immunology

authors： Bergamaschini L,Miedico A,Cicardi M,Coppola R,Faioni EN,Agostoni A

更新日期：1999-05-01 00:00:00