Immunological sequelae of intrauterine infection.

Abstract:

:Compared to normal children, pre-natally infected infants had significantly elevated IgM concentrations throughout the first year of life and elevated IgA levels for the first 6 months. In contrast, IgG levels dropped significantly below normal at 3 months post-partum. Infants born without overt disease but with elevated IgM were found to have precocious development of serum IgA when compared to control children. Levels of IgA and IgG in tears were markedly reduced in symptomatic children at 3 months of age. Lymphocyte response in vitro to phytohaemagglutinin and pokeweed mitogen was low in symptomatic infants. These results suggest that intratuerine infection may result in multiple immunological abnormalities.

journal_name

Clin Exp Immunol

authors

McMurray DN,Rey H

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

389-95

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

44

pub_type

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