Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia.

Abstract:

:Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency disease, characterized by low levels of circulating immunoglobulins and recurrent bacterial infections, particularly of the respiratory tract. T cell dysfunction is often present, and lymphoproliferative and autoimmune disorders as well as haematological cytopenias are frequently observed. In this study, we report a polyclonal expansion of large granular lymphocytes (LGL) in a substantial proportion of CVID patients, associated with splenomegaly, increased numbers of CD8(+) T cells, inverted CD4 : CD8 T cell ratios and neutropenia. CVID patients who had both increased numbers of LGL and granulocytopenia had elevated levels of soluble Fas ligand (sFasL). Our observations indicate that CVID may be added to the list of inflammatory diseases associated with increased numbers of LGL. Furthermore, our findings suggest common pathogenic mechanisms of granulocytopenia in CVID and lymphoproliferative disease of granular lymphocytes.

journal_name

Clin Exp Immunol

authors

Holm AM,Tjønnfjord G,Yndestad A,Beiske K,Müller F,Aukrust P,Frøland SS

doi

10.1111/j.1365-2249.2006.03086.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

418-24

issue

3

eissn

0009-9104

issn

1365-2249

pii

CEI3086

journal_volume

144

pub_type

杂志文章
  • CD56(+dim) and CD56(+bright) cell activation and apoptosis in hepatitis C virus infection.

    abstract::CD3- CD56(+dim) natural killer (NK) cells, which are cytotoxic against virally infected cells, may be important in hepatitis C virus (HCV)-infected patients who are successfully treated with pegylated interferon (PEG-IFN)-alpha. We used flow cytometry to enumerate activated (CD69+) and apoptotic (annexin-V+) dim (CD3-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02523.x

    authors: Lin AW,Gonzalez SA,Cunningham-Rundles S,Dorante G,Marshall S,Tignor A,Ha C,Jacobson IM,Talal AH

    更新日期:2004-08-01 00:00:00

  • T cell activation profiles in Kawasaki syndrome.

    abstract::Superantigens (SAgs) are potent stimulators of T cells bearing specific Vbeta T cell receptors (TCR) and may play a role in the pathogenesis of Kawasaki syndrome (KS), although despite 15 years of intense study this area remains controversial. Because SAgs can cause Vbeta restricted T cell activation in the absence of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2249.2007.03567.x

    authors: Brogan PA,Shah V,Clarke LA,Dillon MJ,Klein N

    更新日期:2008-02-01 00:00:00

  • T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies.

    abstract::Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cel...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Narayanan RB,Bhutani LK,Sharma AK,Nath I

    更新日期:1983-03-01 00:00:00

  • Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects.

    abstract::Complement receptor 1-related gene/protein y (Crry) is a potent murine complement regulator that inhibits C3 convertases. Transgenic mice that overexpress soluble Crry (sCrry), directed systemically by the metallothionein-I promoter, have been used as an animal model for chronic blockade of complement activation. Rece...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02450.x

    authors: Kang HJ,Bao L,Xu Y,Quigg RJ,Giclas PC,Holers VM

    更新日期:2004-05-01 00:00:00

  • Clusterin in renal tissue: preferential localization with the terminal complement complex and immunoglobulin deposits in glomeruli.

    abstract::The membrane attack complex (MAC) of complement is activated by immune and non-immune mechanisms in the kidney. MAC has been found associated with glomerular immune deposits, but also to cell remnants, particularly along tubules and in vessel walls. Clusterin and S-protein (vitronectin) bind to MAC, rendering it cytol...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb06459.x

    authors: French LE,Tschopp J,Schifferli JA

    更新日期:1992-06-01 00:00:00

  • Rearrangement of the human heavy chain variable region gene V3-23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of VHCDR3 and residues intrinsic to the heavy chain variable region.

    abstract::To formulate a 'logic' for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line human V3-23 gene, multiple diversity (D) and joining (J) gene segments. Hybridomas p...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01380.x

    authors: Mageed RA,Harmer IJ,Wynn SL,Moyes SP,Maziak BB,Brüggemann M,MacKworth-Young CG

    更新日期:2001-01-01 00:00:00

  • Mononuclear phagocytes from human bone marrow progenitor cells; morphology, surface phenotype, and functional properties of resting and activated cells.

    abstract::After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1993.tb03375.x

    authors: Keller R,Keist R,Joller P,Groscurth P

    更新日期:1993-01-01 00:00:00

  • Immunological behaviour following rubella infection.

    abstract::Several immunological tests were performed on eighty-five patients with rubella. There was a decrease in total leucocytes, neutrophils and T cells, an increase in IgG and the complement components of C4, C9 and CH50, and a marked insensitivity to dinitrochlorobenzen (DNCB) and purified protein derivative (PPD) in many...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Niwa Y,Kanoh T

    更新日期:1979-09-01 00:00:00

  • T cell subpopulations in CLL: methods of T cell enrichment artificially alter proportions of OKT4 and OKT8 positive cells.

    abstract::There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dickinson AM,George S,Proctor SJ

    更新日期:1983-11-01 00:00:00

  • Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function.

    abstract::Neutrophil recruitment and survival are important control points in the development and resolution of inflammatory processes. 15-epi-lipoxin (LX)A interaction with formyl peptide receptor 2 (FPR2)/ALX receptor is suggested to enhance anti-inflammatory neutrophil functions and mediate resolution of airway inflammation....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12110

    authors: Planagumà A,Domenech T,Jover I,Ramos I,Sentellas S,Malhotra R,Miralpeix M

    更新日期:2013-08-01 00:00:00

  • T cell vaccination in multiple sclerosis patients with autologous CSF-derived activated T cells: results from a pilot study.

    abstract::Myelin-reactive T cells are considered to play an essential role in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. We have previously studied the effects of T cell vaccination (TCV), a procedure by which MS patients are immunized with attenuated autologous myelin basi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02019.x

    authors: Van der Aa A,Hellings N,Medaer R,Gelin G,Palmers Y,Raus J,Stinissen P

    更新日期:2003-01-01 00:00:00

  • Synthesis of alpha 1-anti-trypsin by human monocytes.

    abstract::The present report concerns the site of synthesis of alpha 1-anti-trypsin (alpha 1 AT). In this study circulating cells and tissue fragments were incubated with radioactive amino acids to be incorporated during protein synthesis. The de novo synthesis of proteins was demonstrated by autoradiography of the immunoelectr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: van Furth R,Kramps JA,Diesselhof-den Dulk MM

    更新日期:1983-03-01 00:00:00

  • Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB).

    abstract::The expression of cytokine mRNA species was determined in liver biopsies from six normal subjects, 18 patients with PBC and 14 patients with hepatitis B e antigen (HBeAg)-positive CHB using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique. cDNA, obtained by reverse transcription using oligo d(T) pr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-759.x

    authors: Shindo M,Mullin GE,Braun-Elwert L,Bergasa NV,Jones EA,James SP

    更新日期:1996-08-01 00:00:00

  • Glatiramer acetate attenuates the pro-migratory profile of adhesion molecules on various immune cell subsets in multiple sclerosis.

    abstract::An altered expression pattern of adhesion molecules (AM) on the surface of immune cells is a premise for their extravasation into the central nervous system (CNS) and the formation of acute brain lesions in multiple sclerosis (MS). We evaluated the impact of glatiramer acetate (GA) on cell-bound and soluble AM in the ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12125

    authors: Sellner J,Koczi W,Harrer A,Oppermann K,Obregon-Castrillo E,Pilz G,Wipfler P,Afazel S,Haschke-Becher E,Trinka E,Kraus J

    更新日期:2013-09-01 00:00:00

  • The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta.

    abstract::Diesel exhaust particles (DEP) are known to modulate the production of cytokines associated with acute and chronic respiratory symptoms and allergic respiratory disease. Tolerance is an important mechanism through which the immune system can maintain nonresponsiveness to common environmental antigens. We examined the ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01698.x

    authors: Pacheco KA,Tarkowski M,Sterritt C,Negri J,Rosenwasser LJ,Borish L

    更新日期:2001-12-01 00:00:00

  • Engagement of Toll-like receptor 2 enhances interleukin (IL)-17(+) autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells.

    abstract::Functional analysis of single Toll-like receptors (TLRs) in vivo is necessary to understand how they shape the ocular inflammation involved in uveitis. In this study we explored the role and mechanisms of TLR-2 agonists on the autoreactive T helper type 17 (Th17) response in experimental autoimmune uveitis (EAU). Trea...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12405

    authors: Wei R,Dong L,Xiao Q,Sun D,Li X,Nian H

    更新日期:2014-11-01 00:00:00

  • Hepatitis B surface antigen containing immune complexes occur in seronegative hepatocellular carcinoma patients.

    abstract::IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin solid phase assays in both HBsAg+ and HBsAg- groups of patients with primary hepatocellular carcinoma (HCC). No differences were observed between the two patient groups either in the levels of ant...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Brown SE,Howard CR,Steward MW,Ajdukiewicz AB,Whittle HC

    更新日期:1984-02-01 00:00:00

  • Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent.

    abstract::An association between mannan-binding lectin (MBL) status and severity of lung function impairment in cystic fibrosis (CF) has been found in several studies, but not in others. To explore the possible basis for discrepancies in the literature, we related both MBL and L-ficolin concentrations to lung function and exami...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03151.x

    authors: Muhlebach MS,MacDonald SL,Button B,Hubbard JJ,Turner ML,Boucher RC,Kilpatrick DC

    更新日期:2006-08-01 00:00:00

  • Functional behaviour and immunological phenotype of circulating B lymphocytes in multiple myeloma. Studies with pokeweed mitogen.

    abstract::Peripheral blood B lymphocytes, depleted of adherent cells, from 10 patients with multiple myeloma were cultured in the presence of PWM with autologous or donor T lymphocytes. The results show that: (1) co-cultures with allogeneic T lymphocytes produced more plasma cells than those with autologous ones; (2) the kappa/...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gobbi M,Caligaris-Cappio F,Campana D,Tazzari PL,Bergui L,Cavo M,Tura S

    更新日期:1984-12-01 00:00:00

  • Expression of types I, III and IV collagen genes in fibrotic skin and nerve lesions of toxic oil syndrome patients.

    abstract::We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1993.tb06504.x

    authors: Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

    更新日期:1993-07-01 00:00:00

  • Immunological sequelae of intrauterine infection.

    abstract::Compared to normal children, pre-natally infected infants had significantly elevated IgM concentrations throughout the first year of life and elevated IgA levels for the first 6 months. In contrast, IgG levels dropped significantly below normal at 3 months post-partum. Infants born without overt disease but with eleva...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: McMurray DN,Rey H

    更新日期:1981-05-01 00:00:00

  • Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis.

    abstract::Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Näher H,Sperling U,Takacs L,Hahn H

    更新日期:1985-06-01 00:00:00

  • Respiratory syncytial virus-induced cytokine production by neonatal macrophages.

    abstract::The induction of immunoregulatory cytokines IL-1 beta, IL-6, IL-12, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) was studied with neonatal (cord blood) monocyte-derived macrophages (MDM) after in vitro infection with respiratory syncytial virus (RSV). The expression of mRNAs for these cyto...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-874.x

    authors: Tsutsumi H,Matsuda K,Sone S,Takeuchi R,Chiba S

    更新日期:1996-12-01 00:00:00

  • High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance.

    abstract::Up to 20% of Crohn's disease (CD) patients respond poorly to glucocorticoids (GC). A product of an alternative splicing of the glucocorticoid receptor (GR) premRNA, GRbeta, may play a role as a dominant inhibitor of the glucocorticoid response. Increasing evidence suggests that inflammatory cytokines such as interleuk...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02846.x

    authors: Towers R,Naftali T,Gabay G,Carlebach M,Klein A,Novis B

    更新日期:2005-08-01 00:00:00

  • Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers.

    abstract::The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01136.x

    authors: Araki K,Harada K,Nakamoto K,Shiroma M,Miyakuni T

    更新日期:2000-02-01 00:00:00

  • Widespread IgE-mediated hypersensitivity in Northern Sudan to the chironomid Cladotanytarsus lewisi ('green nimitti').

    abstract::Hypersensitivity to Chironomidae (non-biting midges) has been a problem in Northern Sudan since about 1927 and is probably due to the working of dams which have produced lake-like conditions on parts of the Blue and main Niles where breeding has evidently increased. Studies were undertaken to determine whether this hy...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kay AB,Gad El Rab MO,Stewart J,Erwa HH

    更新日期:1978-10-01 00:00:00

  • Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus.

    abstract::Dogs can develop systemic lupus erythematosus syndromes that are clinically similar to those seen in humans. In contrast, previous observations suggest differences in their autoantibody reactivity patterns against histones and DNA which are components of the nucleosome in chromatin. The objective of this study was to ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb03469.x

    authors: Monestier M,Novick KE,Karam ET,Chabanne L,Monier JC,Rigal D

    更新日期:1995-01-01 00:00:00

  • Bruton's tyrosine kinase expression and activity in X-linked agammaglobulinaemia (XLA): the use of protein analysis as a diagnostic indicator of XLA.

    abstract::Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity in individuals with XLA was performed to characterize the relationship...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gaspar HB,Lester T,Levinsky RJ,Kinnon C

    更新日期:1998-02-01 00:00:00

  • In pursuit of excellence: an integrated care pathway for C1 inhibitor deficiency.

    abstract::There are estimated to be approximately 1500 people in the United Kingdom with C1 inhibitor (C1INH) deficiency. At BartsHealth National Health Service (NHS) Trust we manage 133 patients with this condition and we believe that this represents one of the largest cohorts in the United Kingdom. C1INH deficiency may be her...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12083

    authors: Manson AL,Price A,Dempster J,Clinton-Tarestad P,Greening C,Enti R,Hill S,Grigoriadou S,Buckland MS,Longhurst HJ

    更新日期:2013-07-01 00:00:00

  • Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals.

    abstract::Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Because the knowledge of the cellular immune response to other metals involved in contact allergy has been limited, we investiga...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03226.x

    authors: Minang JT,Areström I,Troye-Blomberg M,Lundeberg L,Ahlborg N

    更新日期:2006-12-01 00:00:00