Anti-actin specificity of human smooth muscle antibodies in chronic active hepatitis.

abstract：:The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC fr...

journal_title：Clinical and experimental immunology

authors： Kurtzhals JA,Hey AS,Jardim A,Kemp M,Schaefer KU,Odera EO,Christensen CB,Githure JI,Olafson RW,Theander TG

更新日期：1994-06-01 00:00:00

abstract：:Serum samples from 64 apparently healthy individuals (32 men and 32 women, mean age 81.0 years) were examined for the prevalence of several autoantibodies, including rheumatoid factor (RF), antinuclear antibodies (ANA), antibodies to extracted cellular antigens Ro (SSA), La (SSB), Sm, U1nRNP and Scl-70. IgG and IgM is...

journal_title：Clinical and experimental immunology

authors： Manoussakis MN,Tzioufas AG,Silis MP,Pange PJ,Goudevenos J,Moutsopoulos HM

更新日期：1987-09-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of PR3-ANCA do not always correspond to clinical disease activity. To investigate the relationship between functional effects of...

journal_title：Clinical and experimental immunology

authors： van der Geld YM,Tool AT,Videler J,de Haas M,Tervaert JW,Stegeman CA,Limburg PC,Kallenberg CG,Roos D

更新日期：2002-09-01 00:00:00

abstract：:Studies in experimental animals suggest that antibody responses to certain polysaccharide antigens may be restricted in IgG subclass distribution. To determine if human antibodies to pneumococcal polysaccharides are similarly restricted we measured the IgG subclass specific response to immunization with purified polyv...

journal_title：Clinical and experimental immunology

authors： Barrett DJ,Ayoub EM

更新日期：1986-01-01 00:00:00

abstract：:The intestinal population of gamma delta T cell receptor (TCR)-bearing cells was characterized with regard to V delta and V gamma subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V delta 1 subtype was demonstrated in the smal...

journal_title：Clinical and experimental immunology

authors： Bucht A,Söderström K,Esin S,Grunewald J,Hagelberg S,Magnusson I,Wigzell H,Grönberg A,Kiessling R

更新日期：1995-01-01 00:00:00

abstract：:The present study demonstrates that tumour necrosis factor (TNF) and FMLP, but not IL-1 or IL-8, enhanced the adherence of polymorphonuclear neutrophil (PMN) to fibronectin, an extracellular matrix protein. The adherence induced by FMLP was very rapid, within 5 min while the induction of adherence by TNF was much slow...

journal_title：Clinical and experimental immunology

authors： Thompson HL,Matsushima K

更新日期：1992-11-01 00:00:00

abstract：:Antilactoferrin antibodies have been reported in patients with several autoimmune disorders, including primary biliary cirrhosis, autoimmune hepatitis and autoimmune cholangitis. We investigated the prevalence and the clinical significance of such autoreactivity in patients with autoimmune and viral chronic liver dise...

journal_title：Clinical and experimental immunology

authors： Muratori L,Muratori P,Zauli D,Grassi A,Pappas G,Rodrigo L,Cassani F,Lenzi M,Bianchi FB

更新日期：2001-06-01 00:00:00

abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

journal_title：Clinical and experimental immunology

authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

更新日期：1979-11-01 00:00:00

abstract：:Immune responses towards malignant plasma cells have clearly been demonstrated in the course of monoclonal B cell dyscrasias and shown to be mostly specific for idiotypic determinants of the monoclonal immunoglobulin (Ig). These responses are specifically efficient against lymphoma cells expressing a membrane form of ...

journal_title：Clinical and experimental immunology

authors： Galea HR,Cogné M

更新日期：2002-08-01 00:00:00

abstract：:An eosinophil stimulating material (ESM) is described in the blister fluids (BF) of six patients with bullous pemphigoid (BP). This ESM is similar in function to a subspecies of human colony stimulating factor (CSF), CSF-alpha, since (i) it stimulated the production from bone marrow cells of day 14 colonies (31 +/- 15...

journal_title：Clinical and experimental immunology

authors： Varigos GA,Morstyn G,Vadas MA

更新日期：1982-12-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships...

journal_title：Clinical and experimental immunology

authors： Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

更新日期：2013-03-01 00:00:00

abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

journal_title：Clinical and experimental immunology

authors： Van Leer EH,Moullier P,Ronco P,Verroust P

更新日期：1987-03-01 00:00:00

abstract：:The technical details of a fixation procedure with formaldehyde which was applied in a direct membrane immunofluorescence technique to mononuclear cells from normal human blood are described. After separation of the cells with Ficoll--Isopaque according to Böyum (1963) they were washed and fixed with 0 . 04% formaldeh...

journal_title：Clinical and experimental immunology

authors： Schuit HR,Hijmans W,Asma GE

更新日期：1980-09-01 00:00:00

abstract：:We have examined the cell-mediated immunity (CMI) to Staphylococcus aureus (S. aureus) and Staphylococcal enterotoxin B (SEB) in peripheral blood mononuclear cells (PBMC) from children with atopic dermatitis (AD) and from non-atopic child controls by measurement of proliferative responses and production of the cytokin...

journal_title：Clinical and experimental immunology

authors： Campbell DE,Kemp AS

更新日期：1997-02-01 00:00:00

abstract：:The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogenic role in murine arthritis. To clarify their pathophysiological roles in patients with rheumatoid arthritis (RA), we examined their expression and localization in peripheral blood mononuclear cells (PBMC). TNFAIP9 and ...

journal_title：Clinical and experimental immunology

authors： Takai C,Matsumoto I,Inoue A,Umeda N,Tanaka Y,Kurashima Y,Wada Y,Narita I,Sumida T

更新日期：2015-06-01 00:00:00

abstract：:Solubilization of an immune precipitate by serum is a complement function mediated by the alternative pathway and enhanced by the classical pathway--it therefore provides the basis of a simple quantitative assessment of the integrity of complement function. Using a preformed radiolabelled precipitate of BSA-alpha BSA ...

journal_title：Clinical and experimental immunology

authors： Schifferli JA,Morris SM,Dash A,Peters DK

更新日期：1981-12-01 00:00:00

abstract：:A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...

journal_title：Clinical and experimental immunology

authors： Zalewski PD,Forbes IJ

更新日期：1979-06-01 00:00:00

abstract：:Intravenous immune globulin (IVIG) preparations are efficacious and safe products in use world-wide. Although rare, side-effects of IVIG may be serious, even life-threatening, and clinicians should be aware of their potential occurrence. This article summarizes most of the adverse experiences with IVIG reported in the...

journal_title：Clinical and experimental immunology

authors： Duhem C,Dicato MA,Ries F

更新日期：1994-07-01 00:00:00

abstract：:Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

journal_title：Clinical and experimental immunology

authors： Löfdahl JM,Wahlström J,Sköld CM

更新日期：2006-09-01 00:00:00

abstract：:We have reported previously that the LAD-4 monoclonal antibody (mAb) directed against a fibronectin receptor (FNR) on RL-male-1 T lymphoma cells in BALB/c mice partially inhibited their migration to the liver. In the present study, we examined the mechanism by which another anti-FNR mAb, LAD-1, exerts its antitumourig...

journal_title：Clinical and experimental immunology

authors： Ito M,Omoto S,Kato Y,Hayashi T,Mori N,Fujii YR

更新日期：2005-07-01 00:00:00

abstract：:Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

journal_title：Clinical and experimental immunology

authors： Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

更新日期：1997-05-01 00:00:00

abstract：:The circulating and cervical B cell responses to Chlamydia trachomatis plasmid protein pgp3 were characterized in children and adults with ocular or genital chlamydial infection using the enzyme-linked immunospot assay (ELISPOT) and ELISA. No pgp3-specific ASCs were detected in healthy controls, but predominantly IgA ...

journal_title：Clinical and experimental immunology

authors： Ghaem-Maghami S,Ratti G,Ghaem-Maghami M,Comanducci M,Hay PE,Bailey RL,Mabey DC,Whittle HC,Ward ME,Lewis DJ

更新日期：2003-06-01 00:00:00

abstract：:The in-vivo clearance of Bordetella pertussis infections in murine models in naive mice and animals vaccinated with whole-cell vaccine is considered to be via a Th-1-dependent mechanism in which interleukin-12 (IL)-12 may play a prominent role. It has also been demonstrated clearly that the treatment of animals with m...

journal_title：Clinical and experimental immunology

authors： Carter CR,Dagg BM,Whitmore KM,Keeble JR,Asokanathan C,Xing D,Walker KB

更新日期：2004-02-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is a new disease which has spread rapidly and widely. We wished to know whether evaluation of in vitro cytokine production could contribute to improved understanding of disease pathogenesis and to better patient management. Numbers of unstimulated and mitogen-stimulated cytokin...

journal_title：Clinical and experimental immunology

authors： Jones BM,Ma ES,Peiris JS,Wong PC,Ho JC,Lam B,Lai KN,Tsang KW

更新日期：2004-03-01 00:00:00

abstract：:To gain insight into possible determinants of in vivo polyclonal B cell activation seen in rheumatoid arthritis (RA), we enumerated immunoglobulin secreting cells appearing in cultures of peripheral blood mononuclear cells that were stimulated with pokeweed mitogen (PWM) or a newly described polyclonal B cell activato...

journal_title：Clinical and experimental immunology

authors： Pardo I,Carafa C,Dziarski R,Levinson AI

更新日期：1984-05-01 00:00:00

abstract：:Several patients with Paget's disease have been reported to have monoclonal IgM proteins in their serum. We have systematically studied 26 patients with Paget's disease severe enough to require diphosphonate therapy. Five of these patients were found to have isolated elevations of serum IgM which were well outside the...

journal_title：Clinical and experimental immunology

authors： Buxbaum JN,Kammerman S

更新日期：1984-04-01 00:00:00

abstract：:Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR) and eight carbohydrate recognition domains (CRD) that bind glycosylated proteins....

journal_title：Clinical and experimental immunology

authors： Chazenbalk GD,Pichurin PN,Guo J,Rapoport B,McLachlan SM

更新日期：2005-02-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

journal_title：Clinical and experimental immunology

authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

更新日期：2000-04-01 00:00:00