High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population.

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:Mice were immunized with the cell wall of BCG suspended in an oil-in-saline emulsion, and examined against time for the emergence of T cell-mediated acquired immunity. Evidence is presented that shows that levels of acquired resistance expressed in these animals over the first month following inoculation, and which en...

journal_title：Clinical and experimental immunology

authors： Orme IM

更新日期：1988-03-01 00:00:00

abstract：:Humans immunized intramuscularly with one dose of tetanus toxoid exhibited IgG, and in some cases IgA antibody, in their bile as well as serum. Both isotypes appeared in bile transiently with titres declining after about day 10 for both classes. These kinetics resembled those of the serum IgA response but were markedl...

journal_title：Clinical and experimental immunology

authors： Hansen PG,Hennessy EJ,Blake H,Clancy RL,Kamath R,Molenaar C,Cripps AW,Jackson GD

更新日期：1989-08-01 00:00:00

abstract：:We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease. The 68 centres were divided according to their geographical location into eight groups, and twice a year (tests A and B...

journal_title：Clinical and experimental immunology

authors： Pandolfi F,Alario C,Girardi E,Rava L,Ippolito G,Kunkl A,Aiuti F

更新日期：1998-03-01 00:00:00

abstract：:The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

journal_title：Clinical and experimental immunology

authors： Rook GA

更新日期：1975-07-01 00:00:00

abstract：:It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors (IL-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51:3011-7). We have also reported that human renal cell carcinoma cells express high-affinity IL-4R, and IL-4 inhibits tumour growth in v...

journal_title：Clinical and experimental immunology

authors： Obiri NI,Siegel JP,Varricchio F,Puri RK

更新日期：1994-01-01 00:00:00

abstract：:The expression and up-regulation of cell adhesion molecules on a human colonic epithelial cell line HT-29, and the peripheral blood T lymphocyte proliferation responses to bacterial superantigens presented by this cell line were investigated, compared with peripheral blood monocytes. In HT-29 cells, there was constitu...

journal_title：Clinical and experimental immunology

authors： Liu ZX,Sugawara S,Hiwatashi N,Noguchi M,Rikiishi H,Kumagai K,Toyota T

更新日期：1997-06-01 00:00:00

abstract：:Peripheral blood B lymphocytes, depleted of adherent cells, from 10 patients with multiple myeloma were cultured in the presence of PWM with autologous or donor T lymphocytes. The results show that: (1) co-cultures with allogeneic T lymphocytes produced more plasma cells than those with autologous ones; (2) the kappa/...

journal_title：Clinical and experimental immunology

authors： Gobbi M,Caligaris-Cappio F,Campana D,Tazzari PL,Bergui L,Cavo M,Tura S

更新日期：1984-12-01 00:00:00

abstract：:Listeriolysin O (LLO) has been proposed as a potential carrier or adjuvant molecule in the vaccination field. However, the cytotoxic and pro-apoptotic effects of LLO are the major limitations for this purpose. Here, we have performed a preclinical safety evaluation and characterized a new potential adjuvant applicatio...

journal_title：Clinical and experimental immunology

authors： Hernández-Flores KG,Calderón-Garcidueñas AL,Mellado-Sánchez G,Ruiz-Ramos R,Sánchez-Vargas LA,Thomas-Dupont P,Izaguirre-Hernández IY,Téllez-Sosa J,Martínez-Barnetche J,Wood L,Paterson Y,Cedillo-Barrón L,López-Franco O,Vivanco-Ci

更新日期：2017-04-01 00:00:00

abstract：:A 7 month old girl with severe combined immunodeficiency disease (SCID) received a single transfusion of peripheral blood leucocytes from her histocompatible grandfather in an attempt to achieve immunological reconstitution. There was rapid restoration of humoral and cellular immunity which has persisted undiminished ...

journal_title：Clinical and experimental immunology

authors： Polmar SH,Schacter BZ,Sorensen RU

更新日期：1986-06-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Ahern J,Liew CL,Hopkins P,Chambers DC,Reynolds PN,Holmes M

更新日期：2009-11-01 00:00:00

abstract：:Benznidazole (BZL) is a nitroheterocyclic drug employed in the chemotherapy of Chagas' disease, a protozoan disease caused by Trypanosoma cruzi. Because this parasite mostly replicates in macrophages, we investigated whether BZL was likely to modify the synthesis of macrophage mediators such as nitrite, tumour necrosi...

journal_title：Clinical and experimental immunology

authors： Revelli S,Le Page C,Piaggio E,Wietzerbin J,Bottasso O

更新日期：1999-11-01 00:00:00

abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

journal_title：Clinical and experimental immunology

authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

更新日期：1980-11-01 00:00:00

abstract：:Lewis rats were immunized with bee venom allergen in Freund's complete adjuvant (FCA) or with FCA only. Animals immunized with bee venom developed specific IgG antibodies but no specific IgE antibodies were detected. Lymphocytes from lymph nodes when cultured with antigen in vitro showed an increased stimulation index...

journal_title：Clinical and experimental immunology

authors： Schneider H,Urbanek R

更新日期：1984-08-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein compose...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Ciccia F,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Guggino G,Di Bartolomeo S,Triolo G,Giacomelli R

更新日期：2016-10-01 00:00:00

abstract：:The chemotactic responsiveness of peripheral blood monocytes was evaluated in three groups of subjects: 32 patients with multiple myeloma, 27 subjects with benign monoclonal gammapathy, and 64 normal controls. Monocyte chemotactic responsiveness was significantly depressed both in multiple myeloma patients (P less tha...

journal_title：Clinical and experimental immunology

authors： Dammacco F,Miglietta A,Ventura MT,Bonomo L

更新日期：1982-02-01 00:00:00

abstract：:Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

journal_title：Clinical and experimental immunology

authors： Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

更新日期：2009-05-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:Female Hartley guinea-pigs were immunized with N-phthaloylated ox insulin (96% NA1,NB1,NB29-triphthaloyl ox insulin) using H. pertussis as adjuvant. Haptenic antibody, which was found in antisera taken 20 days after secondary immunization, was assessed for cross-reaction with a series of N-acylated ox insulins. Cross-...

journal_title：Clinical and experimental immunology

authors： Hollins PJ,Nathan MM

更新日期：1978-03-01 00:00:00

abstract：:Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

journal_title：Clinical and experimental immunology

authors： Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

更新日期：2002-10-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

journal_title：Clinical and experimental immunology

authors： Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

更新日期：2019-03-01 00:00:00

abstract：:alpha 1-Microglobulin (alpha 1-m) was purified by column chromatography from a supernatant fluid of cultured T and B lymphocytes stimulated with mitogens. This protein had a molecular weight of 33,000 as determined by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, migrated in the alpha 1-region on i...

journal_title：Clinical and experimental immunology

authors： Itoh Y,Kin K,Kasahara T,Sakurabayashi I,Kawai T,Shiori-Nakano K,Takagi K

更新日期：1979-07-01 00:00:00

abstract：:A method is described to assess antigenic cross-reactivity between soluble immune complexes precipitated from sera with polyethylene glycol. The precipitated complex from one serum was dissociated in acid and used to coat a plastic cup. Radioiodinated complexes from another serum were dissociated in the cup, neutraliz...

journal_title：Clinical and experimental immunology

authors： Dambuyant C,Burton-Kee J,Mowbray JF

更新日期：1979-09-01 00:00:00

abstract：:The reproducibility of a simplified, sensitive and rapid agarose-cell droplet assay for leucocyte migration inhibition factor (LIF) activity was studied. Removal of T cells with anti-T-cell serum eliminated LIF activity, indicating that in humans it is probably the T cell that produces LIF. Cord blood lymphocytes prod...

journal_title：Clinical and experimental immunology

authors： Hahn T,Levin S,Handzel ZT

更新日期：1976-06-01 00:00:00

abstract：:Peripheral blood mononuclear cells from 14 healthy donors and 22 allergic patients were incubated with 51Cr-labelled chicken erythrocytes coated with an IgE myeloma protein or rabbit IgG antibodies. Mononuclear cells from patients with severe atopic disorders released a significantly greater percentage of 51Cr (P less...

journal_title：Clinical and experimental immunology

authors： Melewicz FM,Zeiger RS,Mellon MH,O'Connor RD,Spiegelberg HL

更新日期：1981-03-01 00:00:00

abstract：:The frequency and specificity of antibodies to native and denatured collagens were evaluated in systemic sclerosis (SSc) and in primary Raynaud's phenomenon (PRP) by direct and competitive ELISA. Antibodies reactive with denatured collagen type I (CI) were found in 43% of the SSc sera, and anti-CIV and anti-CV in 31%....

journal_title：Clinical and experimental immunology

authors： Riente L,Marchini B,Dolcher MP,Puccetti A,Bombardieri S,Migliorini P

更新日期：1995-11-01 00:00:00

abstract：:Allele variants in the L-carnitine (LCAR) transporters OCTN1 (SLC22A4, 1672 C --> T) and OCTN2 (SLC22A5, -207 G --> C) have been implicated in susceptibility to Crohn's disease (CD). LCAR is consumed in the diet and transported actively from the intestinal lumen via the organic cation transporter OCTN2. While recogniz...

journal_title：Clinical and experimental immunology

authors： Fortin G,Yurchenko K,Collette C,Rubio M,Villani AC,Bitton A,Sarfati M,Franchimont D

更新日期：2009-04-01 00:00:00

abstract：:We have investigated TNF-alpha secretory response of peripheral blood mononuclear cells (PBMC) from 13 uraemic patients undergoing regular haemodialysis with cuprophane membrane (CM). Sixteen healthy subjects and five uraemic patients under conservative therapy were also studied as controls. Cells of haemodialysis pat...

journal_title：Clinical and experimental immunology

authors： Annenkov AY,Strokov AG,Baranova FS

更新日期：1992-10-01 00:00:00

abstract：:CD4+CD25+ T regulatory cells may play a role in the different clinical presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell responses. Peripheral CD4+CD25+ T cells from chronic HCV carriers with normal and abnormal alanine aminotransferase (ALT) were analysed for specificity and effect...

journal_title：Clinical and experimental immunology

authors： Bolacchi F,Sinistro A,Ciaprini C,Demin F,Capozzi M,Carducci FC,Drapeau CM,Rocchi G,Bergamini A

更新日期：2006-05-01 00:00:00

abstract：:Anti-CD2 MoAbs have previously been shown to induce tolerance and to block B cell differentiation, T cell and monocyte activation. Since these immune functions are important in joint inflammation, we asked whether administration of the anti-CD2 MoAb OX34 has a beneficial effect on established rat adjuvant arthritis, a...

journal_title：Clinical and experimental immunology

authors： Hoffmann JC,Herklotz C,Zeidler H,Bayer B,Westermann J

更新日期：1997-10-01 00:00:00