当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis.

Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis.

Abstract：

:Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships between the degree of TSLP expression in the skin and the severity of AD, epidermal barrier function and eruption type remain to be elucidated. The aim of this study was to examine the relationships between the degree of TSLP expression in the skin and the severity of AD, eruption type and epidermal barrier function using a non-invasive method in a sizeable group of the patients. Stratum corneum tissue was obtained from AD patients by tape stripping, and the stratum corneum TSLP (scTSLP) expression level was evaluated using a TSLP-specific antibody followed by image analysis. The correlations between the scTSLP intensity and the severity scoring of AD (SCORAD) index and epidermal barrier function, such as stratum corneum hydration and transepidermal water loss (TEWL), were analysed. The changes in the scTSLP level induced by the application of moisturizer were also examined. The scTSLP expression level was increased in AD patients compared with healthy subjects and was correlated with SCORAD, especially with the dry skin score, and stratum corneum hydration. Moisturizer application resulted in reduced scTSLP levels. The scTSLP level can be used as a biomarker of AD severity and particularly epidermal barrier status.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

doi

10.1111/cei.12021

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

330-7

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

171

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Deficient expression of MHC class II antigens in some cases of human B cell leukaemia.

    abstract：:Cells from the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL) and acute lymphoblastic leukaemia (ALL) were examined for the expression of MHC class II antigens, using a number of monoclonal antibodies (MoAb) including L243 (anti-DR) and TU22 (anti-DQ). There was wide variation in expres...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Guy K,Docherty LJ,Dewar AE

    更新日期：1986-02-01 00:00:00

  • The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia.

    abstract：:One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA....

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Izui S,Lambert PH,Carpentier N,Miescher PA

    更新日期：1976-06-01 00:00:00

  • Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation.

    abstract：:CVID is a primary immune disorder in which hypogammaglobulinaemia may be associated with a number of T cell defects including lymphopenia, anergy, impaired lymphocyte proliferation and deficient cytokine secretion. In this study we show that T cells of CVID subjects, in comparison with control T cells, undergo spontan...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01239.x

    authors： Di Renzo M,Zhou Z,George I,Becker K,Cunningham-Rundles C

    更新日期：2000-06-01 00:00:00

  • A high level of serum neopterin is associated with rapidly progressive interstitial lung disease and reduced survival in dermatomyositis.

    abstract：:Neopterin is primarily synthesized and released by activated macrophages/monocytes upon stimulation with interferon-γ and is considered as a marker for macrophage activation. This study aimed to analyze the serum levels of neopterin in patients with dermatomyositis (DM) in association with clinical manifestations, lab...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13404

    authors： Peng QL,Zhang YM,Liang L,Liu X,Ye LF,Yang HB,Zhang L,Shu XM,Lu X,Wang GC

    更新日期：2020-03-01 00:00:00

  • Cross-reactive antibodies between HIV-gp120 and platelet gpIIIa (CD61) in HIV-related immune thrombocytopenic purpura.

    abstract：:We have previously demonstrated that immune platelet destruction observed in an AIDS-free HIV-infected patient was associated with the presence of a cross-reactive antibody recognizing both HIV-glycoprotein (gp)120 and platelet gpIIIa (CD61). We have now investigated the presence of such antibodies in other HIV-infect...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.917606.x

    authors： Bettaieb A,Oksenhendler E,Duedari N,Bierling P

    更新日期：1996-01-01 00:00:00

  • Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients.

    abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2249.2000.01187.x

    authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

    更新日期：2000-04-01 00:00:00

  • Interstitial mononuclear cell infiltration in Heymann nephritis.

    abstract：:Interstitial mononuclear cell infiltration in rats during the development of autoimmune Heymann nephritis (HN) was studied using the fine-needle aspiration biopsy (FNAB) technique. The results were compared with those obtained by immunohistochemical studies of infiltrating T helper (T-h) and T suppressor/cytotoxic (T-...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Grönhagen-Riska C,Honkanen E,von Willebrand E,Tikkanen I,Miettinen A,Holthöfer H,Törnroth T

    更新日期：1987-11-01 00:00:00

  • Reactivity of normal rat epiphyseal chondrocytes with monoclonal antibodies recognizing different leucocyte markers.

    abstract：:The aim of the study was to test whether normal rat epiphyseal chondrocytes react with monoclonal antibodies (MoAbs) detecting different markers of lymphoid cells. For this purpose, isolated chondrocyte and, for comparison, splenocyte cytosmears were exposed to a battery of different MoAbs followed by indirect immunop...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Malejczyk J,Romaniuk A

    更新日期：1989-03-01 00:00:00

  • Interactions of Mycobacterium lepraemurium with resident peritoneal macrophages; phagocytosis and stimulation of the oxidative burst.

    abstract：:Live Mycobacterium lepraemurium or 60Co-gamma-irradiated organisms stimulated a very weak oxidative burst compared with similar numbers of heat-killed organisms or with live M. microti. This was found to reflect the poor uptake of the living organisms rather than an absolute failure to stimulate an oxidative burst. It...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Brett SJ,Butler R

    更新日期：1988-01-01 00:00:00

  • Interferon deficiency syndrome.

    abstract：:Activation of the interferon (IFN) system is an early defence mechanism against viral infections. The virus stimulates production of IFN by nucleated cells including the peripheral blood mononuclear cells (PBMC), and this IFN in turn activates several IFN-dependent immune mechanisms including the induction of an anti-...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Levin S,Hahn T

    更新日期：1985-05-01 00:00:00

  • Long-term immunological reconstitution by peripheral blood leucocytes in severe combined immune deficiency disease: implications for the role of mature lymphocytes in histocompatible bone marrow transplantation.

    abstract：:A 7 month old girl with severe combined immunodeficiency disease (SCID) received a single transfusion of peripheral blood leucocytes from her histocompatible grandfather in an attempt to achieve immunological reconstitution. There was rapid restoration of humoral and cellular immunity which has persisted undiminished ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Polmar SH,Schacter BZ,Sorensen RU

    更新日期：1986-06-01 00:00:00

  • Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigens recognized by HIV-, CMV+ individuals.

    abstract：:In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05490.x

    authors： Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

    更新日期：1990-12-01 00:00:00

  • IgE rheumatoid factors: quantification in synovial fluid and ability to induce synovial mast cell histamine release.

    abstract：:IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten control samples. Synovial fluid IgE RF activity was higher than predicted by diffusion alone in 7/11 (64%) of the RA syn...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gruber B,Ballan D,Gorevic PD

    更新日期：1988-02-01 00:00:00

  • Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease.

    abstract：:The family of Toll-like receptors (TLRs) initiates innate immune responses, and Toll-like receptor 4 (TLR4) was considered to be an important player in the initiation and progression of atherosclerotic disease. The aim of the study was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs)...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2005.02982.x

    authors： Geng HL,Lu HQ,Zhang LZ,Zhang H,Zhou L,Wang H,Zhong RQ

    更新日期：2006-02-01 00:00:00

  • Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals.

    abstract：:The immune modulating capacity of vitamin D(3) is well-recognized. Ultra-violet (UV) exposure determines production of vitamin D(3) in vivo and varies through the course of the year, especially in temperate regions. However, it is not known whether the human innate immune response differs due to seasonality. To valida...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2010.04315.x

    authors： Khoo AL,Chai LY,Koenen HJ,Sweep FC,Joosten I,Netea MG,van der Ven AJ

    更新日期：2011-04-01 00:00:00

  • Abnormalities in the immune system of children with beta-thalassaemia major.

    abstract：:We have studied both the humoral and cell mediated immune systems of 23 children with beta-thalassaemia major. In children who had not been splenectomized, a 3-fold expansion in the number of circulating B cells and a modest polyclonal gammopathy was present. Of these patients 70% had decreased numbers of circulating ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dwyer J,Wood C,McNamara J,Williams A,Andiman W,Rink L,O'Connor T,Pearson H

    更新日期：1987-06-01 00:00:00

  • A search for circulating immune complex-like material during the course of autoimmune complex glomerulonephritis in Lewis and Brown Norway rats.

    abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Zanetti M,Bellon B,Verroust P,Druet P

    更新日期：1980-10-01 00:00:00

  • Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.

    abstract：:Low-density cells (LDC) of dendritic morphology from the blood of patients with common variable (late-onset) hypogammaglobulinaemia (CVH) did not induce allogeneic immunoglobulin production by normal B cells unlike LDC from normal blood. When LDC from patients were treated with pokeweed mitogen (PWM), a lower allogene...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Farrant J,Bryant AE,Lever AM,Edwards AJ,Knight SC,Webster AD

    更新日期：1985-07-01 00:00:00

  • Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals.

    abstract：:Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Because the knowledge of the cellular immune response to other metals involved in contact allergy has been limited, we investiga...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03226.x

    authors： Minang JT,Areström I,Troye-Blomberg M,Lundeberg L,Ahlborg N

    更新日期：2006-12-01 00:00:00

  • Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C.

    abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12158

    authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

    更新日期：2013-10-01 00:00:00

  • An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes.

    abstract：:The pattern of T cell receptor V gene expression by lymphocytes from rheumatoid synovial fluid and paired peripheral blood samples was compared using a polymerase chain reaction (PCR)-based assay. Eight rheumatoid arthritis (RA) patients who had varying durations of disease (from 2 to 20 years) were studied. In all pa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb05865.x

    authors： Lunardi C,Marguerie C,So AK

    更新日期：1992-12-01 00:00:00

  • Inverted V delta 1/V delta 2 ratio within the T cell receptor (TCR)-gamma delta T cell population in peripheral blood of heart transplant recipients.

    abstract：:We investigated the levels of TCR-gamma delta T cells and their subpopulations V delta 1 and V delta 2 in the peripheral blood lymphocytes (PBL) of 28 heart transplant (HTx) patients. Patients (n = 10) receiving cyclosporin A (CsA) for treatment of a nephrotic syndrome (NS) and 10 healthy individuals served as control...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.909604.x

    authors： Vaessen LM,Schipper F,Knoop C,Claas FH,Weimar W

    更新日期：1996-01-01 00:00:00

  • Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis.

    abstract：:Plasmacytoid dendritic cells (pDCs) are of crucial importance in immune regulation and response to microbial factors. In multiple sclerosis (MS), pDCs from peripheral blood showed an immature phenotype, but its role in susceptibility to MS is not determined. Because infectious diseases are established triggers of exac...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2009.03964.x

    authors： Bayas A,Stasiolek M,Kruse N,Toyka KV,Selmaj K,Gold R

    更新日期：2009-09-01 00:00:00

  • Effect of 12,13-phorbol dibutyrate and ionomycin on defective B cells in common variable immunodeficiency.

    abstract：:Secretion of IgM and IgG in vitro by B cells from patients with common variable immunodeficiency (CVI) has been used to classify the disease into three groups. On stimulation with anti-IgM and IL-2, group A patients' cells fail to secrete IgM or IgG, group B patients' cells secrete no IgG and significantly lower level...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb03020.x

    authors： Franz A,Bryant A,Webster AD,Farrant J

    更新日期：1992-03-01 00:00:00

  • Immunosuppressant effect of gold on IgG subclasses and IgE; evidence for sparing of Th2 responses.

    abstract：:We set out to examine the effect of gold treatment on the Th2-dependent antibodies IgG4 and IgE in relation to other IgG subclasses in patients with rheumatoid arthritis (RA). Eighty-five gold-treated RA patients and 82 RA controls were studied. Serum IgG subclass concentrations were measured by ELISA, IgE was measure...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01207.x

    authors： Kiely PD,Helbert MR,Miles J,Oliveira DB

    更新日期：2000-05-01 00:00:00

  • Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration.

    abstract：:In order to investigate the T cell cytokine profile during age-dependent maturation of the immune response, we evaluated the cytokine expression of CD4+ and CD8+ circulating cells by flow cytometric single-cell analysis after non-specific stimulation in vitro in different age groups of normal individuals, from cord bl...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00977.x

    authors： Krampera M,Vinante F,Tavecchia L,Morosato L,Chilosi M,Romagnani S,Zanolin ME,Pizzolo G

    更新日期：1999-08-01 00:00:00

  • Autoimmunity to endometrium and ovary in endometriosis.

    abstract：:Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0....

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Mathur S,Peress MR,Williamson HO,Youmans CD,Maney SA,Garvin AJ,Rust PF,Fudenberg HH

    更新日期：1982-11-01 00:00:00

  • Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity.

    abstract：:Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Facer CA,Bray RS,Brown J

    更新日期：1979-01-01 00:00:00

  • Human peripheral blood T lymphocyte subpopulations isolated on the basis of their affinity for sheep red blood cells differ in angiogenesis-inducing capability.

    abstract：:Human peripheral blood lymphocytes injected intradermally into X-ray immunosuppressed mice were tested for angiogenesis-inducing capacity. Both T and B lymphocytes evoked angiogenesis of the same intensity. The total T cell population was fractionated into three subpopulations on the basis of their different affinitie...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kamiński MJ,Nowacyk M,Skopińska-Rozewska E,Kamińska G,Bem W

    更新日期：1981-11-01 00:00:00

  • The effect of levamisole on cellular immunity in multiple sclerosis.

    abstract：:The lymphocyte stimulation test has been standardized in a normal human population using four virus cell-associated antigens (VCAA): human embryonic lung cells infected with the LEC and Norrby strains of measles virus, mumps virus, and vaccinia virus. Following 1 week of treatment with the immunopotentiating drug leva...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dau PC,Johnson KP,Spitler LE

    更新日期：1976-11-01 00:00:00