Abstract:
:The injection of acetylcholine receptor (AChR) purified from Narke electroplax japonica induced 'experimental autoimmune myasthenia gravis' (EAMG) in rabbits. Serial measurements of anti-AChR antibody titre using Narke AChR and rabbit AChR as antigen revealed that the intensity of myasthenia had a rather closer correlation with titre to Narke AChR than that to rabbit AChR. Antibody reacting to rabbit AChR was almost completely adsorbed out with torpedo receptor conjugated to agarose. Serum concentrations of antibody protein measured by affinity chromatography ranged from 54 to 896 microgram/ml serum and were well correlated with the intensity of myasthenia. The results suggested that in rabbits immunized with heterologous AChR the cross-reaction of anti-heterologous AChR antibody with rabbit AChR caused myasthenia rather than an immune response specific to rabbit AChR dose.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Ueno S,Kang J,Takeuchi H,Takahashi M,Tarui Ssubject
Has Abstractpub_date
1980-07-01 00:00:00pages
13-8issue
1eissn
0009-9104issn
1365-2249journal_volume
41pub_type
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