Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes.

abstract：:Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression o...

journal_title：Clinical and experimental immunology

authors： Nagaraju K,Raben N,Merritt G,Loeffler L,Kirk K,Plotz P

更新日期：1998-09-01 00:00:00

abstract：:Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order to elucidate the role of PDE7 in human T cell function, the effects of two PDE inhibitors on PDE7A activity, cytokine ...

journal_title：Clinical and experimental immunology

authors： Nakata A,Ogawa K,Sasaki T,Koyama N,Wada K,Kotera J,Kikkawa H,Omori K,Kaminuma O

更新日期：2002-06-01 00:00:00

abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

journal_title：Clinical and experimental immunology

authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

更新日期：1984-06-01 00:00:00

abstract：:Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-...

journal_title：Clinical and experimental immunology

authors： Faisant C,Boccon-Gibod I,Mansard C,Dumestre Perard C,Pralong P,Chatain C,Deroux A,Bouillet L

更新日期：2016-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise destruction of a single endocrine cell type occurring on a distinct genetic and autoimmune background - have been unravelled in recent years to such an extent tha...

journal_title：Clinical and experimental immunology

authors： Staeva-Vieira T,Peakman M,von Herrath M

更新日期：2007-04-01 00:00:00

abstract：:Lymphocytotoxic activity has been found by previous investigators in multiple sclerosis (MS) sera. We confirmed the presence of this activity in MS sera using techniques designed to eliminate possible sources of erroneous conclusion not considered in previous studies. We further characterized this activity and found i...

journal_title：Clinical and experimental immunology

authors： Scott CF,Spitler LE

更新日期：1983-07-01 00:00:00

abstract：:Type 1 IFN is thought to be implicated in the autoimmune process of SLE. Plasmacytoid dendric cells (DC), which are natural IFN-alpha producing cells, play a pivotal epipathogenic role in SLE. The present study was undertaken to investigate the phenotypic characteristics of peripheral blood DC in SLE patients in compa...

journal_title：Clinical and experimental immunology

authors： Migita K,Miyashita T,Maeda Y,Kimura H,Nakamura M,Yatsuhashi H,Ishibashi H,Eguchi K

更新日期：2005-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

journal_title：Clinical and experimental immunology

authors： Yao QY,Rickinson AB,Gaston JS,Epstein MA

更新日期：1986-05-01 00:00:00

abstract：:Macrophages separated from lavage samples obtained from lungs removed at transplantation from patients with cystic fibrosis (CF) and other lung diseases, have been compared with circulating monocytes from the same patients for their ability to stimulate allogeneic normal circulating lymphocytes and to present antigen ...

journal_title：Clinical and experimental immunology

authors： Knight RA,Kollnberger S,Madden B,Yacoub M,Hodson ME

更新日期：1997-03-01 00:00:00

abstract：:To define the role of quantitative graft composition and donor killer-cell immunoglobulin-like receptor (KIR) genotype in clinical outcome following unmanipulated peripheral blood stem cell transplantation (PBSCT) from human leucocyte antigen (HLA)-identical siblings, 43 consecutive transplants for haematological mali...

journal_title：Clinical and experimental immunology

authors： Clausen J,Wolf D,Petzer AL,Gunsilius E,Schumacher P,Kircher B,Gastl G,Nachbaur D

更新日期：2007-06-01 00:00:00

abstract：:There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

journal_title：Clinical and experimental immunology

authors： Dickinson AM,George S,Proctor SJ

更新日期：1983-11-01 00:00:00

abstract：:Intraperitoneal infection of mice with mycobacteria induces the persistent mobilization of neutrophils to the infected peritoneal cavities. The recruitment of the neutrophils was mediated by the immune system since it was enhanced by immunization and reduced in T cell-deficient nude and SCID mice. Anti-mitotic treatme...

journal_title：Clinical and experimental immunology

authors： Appelberg R

更新日期：1992-07-01 00:00:00

abstract：:Native human CRP in solution formed complexes with the abnormal lipoprotein beta-VLDL in serum of patients with type III hyperlipoproteinaemia. CRP also formed complexes in sera from individuals with type IV and type V hyperlipoproteinaemia. The binding was calcium-dependent and inhibitable by free phosphoryl choline....

journal_title：Clinical and experimental immunology

authors： Rowe IF,Soutar AK,Trayner IM,Thompson GR,Pepys MB

更新日期：1984-10-01 00:00:00

abstract：:Human peripheral blood lymphocytes were examined for rosette formation with autologous erythrocytes. When normal human lymphocytes were stimulated with phorbol myristate acetate (PMA) in the presence of autologous serum, the levels of autorosette forming cells (ARFC) were strongly enhanced. Pre-culture was necessary f...

journal_title：Clinical and experimental immunology

authors： Sakano T,Hyodo S,Kittaka E,Tanaka Y,Usui T

更新日期：1982-09-01 00:00:00

abstract：:Mucosal candidiasis is one of the first opportunistic diseases in HIV-infected subjects. In order to understand the relationship between this disease and immunodeficiency to chemically defined, immunodominant Candida antigens, a mannoprotein fraction from C. albicans cell wall (GMP) was used to analyse proliferative a...

journal_title：Clinical and experimental immunology

authors： Quinti I,Palma C,Guerra EC,Gomez MJ,Mezzaroma I,Aiuti F,Cassone A

更新日期：1991-09-01 00:00:00

abstract：:In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins an...

journal_title：Clinical and experimental immunology

authors： Stevens WJ,Peetermans ME,Van Acker KJ

更新日期：1979-06-01 00:00:00

abstract：:In vitro inducible suppressor cell precursors were detected in the spleen of BALB/c but not in DBA/2 mice infected intraperitoneally with 10(8) Mycobacterium lepraemurium bacilli, thus suggesting that their development is genetically controlled. Two pairs of mouse strains congenic at the Ity/Lsh/Bcg locus (BALB/c-C.D2...

journal_title：Clinical and experimental immunology

authors： Gosselin D,Turcotte R,Lemieux S

更新日期：1994-05-01 00:00:00

abstract：:The influence of cyclosporin A (CsA) on type II collagen-induced arthritis (CIA) in the rhesus monkey has been investigated. CsA was administered subcutaneously in a dose of 25 mg/kg per day during 9-18 days and additionally 12.5 mg/kg per day for 7 days. At this dosing regime no significant alterations of haematologi...

journal_title：Clinical and experimental immunology

authors： Bakker NP,Van Besouw N,Groenestein R,Jonker M,Hart LA

更新日期：1993-09-01 00:00:00

abstract：:In autoimmune diseases, mitogen-induced IL-2 production in vitro is generally considered to be diminished despite evidence of lymphoid hyperactivity in vivo. HgCl2 is known to cause T-dependent polyclonal B cell activation in Brown-Norway (BN) rats, resulting in autoimmune disease. We show here that the IL-2 producing...

journal_title：Clinical and experimental immunology

authors： Baran D,Lantz O,Dosquet P,Sfaksi A,Druet P

更新日期：1988-09-01 00:00:00

abstract：:The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

journal_title：Clinical and experimental immunology

authors： Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

更新日期：1979-10-01 00:00:00

abstract：:The binding of anti-DNA antibodies to the endothelial cell is mediated through DNA, which forms a bridge between the immunoglobulin and the plasma membrane. We have shown that 32P-labelled DNA bound to the plasma membrane of human umbilical vein endothelial cells (HUVEC) by a saturable process, which could be competit...

journal_title：Clinical and experimental immunology

authors： Chan TM,Frampton G,Cameron JS

更新日期：1993-01-01 00:00:00

abstract：:The relation of clinical and laboratory findings at the time clinical presentation to subsequent survival was investigated in 204 patients with macroglobulinaemia. It was found that the ten following clinical and laboratory parameters were of prognostic significance and a further twelve were not. The best prognoses we...

journal_title：Clinical and experimental immunology

authors： Carter P,Koval JJ,Hobbs JR

更新日期：1977-05-01 00:00:00

abstract：:CD30 is a surface molecule which can be expressed by normal B and T lymphocytes. Our study focused on the CD30 expression and release compared with IL-4 expression as well as CD23-alpha/beta in peripheral blood mononuclear cells (PBMC) from atopic subjects and controls. Data showed a lack of CD30 mRNA expression in th...

journal_title：Clinical and experimental immunology

authors： Esnault S,Benbernou N,Lavaud F,Guenounou M

更新日期：1996-10-01 00:00:00

abstract：:Earlier data suggest that gamma/delta T cells may play an important role in the immune response to Mycobacterium tuberculosis. The aim of this study was to determine the percentage of different gamma/delta subsets in peripheral blood of active tuberculosis patients with a positive or negative tuberculin reaction. Thir...

journal_title：Clinical and experimental immunology

authors： Szereday L,Baliko Z,Szekeres-Bartho J

更新日期：2003-02-01 00:00:00

abstract：:Anti-idiotypic antibodies (anti-Id Abs) are involved in the regulation of a number of immune responses including the IgE antibody production. In atopic patients, the increased synthesis of IgE antibodies could be related to a defective production of regulatory anti-Id Abs. In the present study, we first developed a se...

journal_title：Clinical and experimental immunology

authors： Hébert J,Bernier D,Mourad W

更新日期：1990-06-01 00:00:00

abstract：:The reproducibility of a simplified, sensitive and rapid agarose-cell droplet assay for leucocyte migration inhibition factor (LIF) activity was studied. Removal of T cells with anti-T-cell serum eliminated LIF activity, indicating that in humans it is probably the T cell that produces LIF. Cord blood lymphocytes prod...

journal_title：Clinical and experimental immunology

authors： Hahn T,Levin S,Handzel ZT

更新日期：1976-06-01 00:00:00

abstract：:Serum IgD levels in 83 healthy adults were measured by a radioimmunoassay technique and analysed according to each subject's smoking habit. The IgD geometric mean in cigarette smokers was twice as high as in non-smokers (408.6 vs 202.0 micrograms/dl). Serum IgD levels of 1,000 micrograms/dl or greater were noted in 22...

journal_title：Clinical and experimental immunology

authors： Bahna SL,Heiner DC,Myhre BA

更新日期：1983-03-01 00:00:00

abstract：:The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes fr...

journal_title：Clinical and experimental immunology

authors： Zwilling BS,Darrow R,Mcpeek M,Laufman H,Pearl D

更新日期：1990-12-01 00:00:00

abstract：:The IL-15 triggering effect of gliadin is not exclusive to coeliac disease (CD) patients, whereas the secondary response is CD specific. We have studied the expression of the IL-15 receptor, and the IL-15 response upon stimulation, in non-CD and CD patients, and the possible existence of a lower immunological threshol...

journal_title：Clinical and experimental immunology

authors： Bernardo D,Garrote JA,Allegretti Y,León A,Gómez E,Bermejo-Martin JF,Calvo C,Riestra S,Fernández-Salazar L,Blanco-Quirós A,Chirdo F,Arranz E

更新日期：2008-10-01 00:00:00

abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

journal_title：Clinical and experimental immunology

authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

更新日期：2020-09-01 00:00:00