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The anti-arthritic and immunosuppressive effects of cyclosporin A on collagen-induced arthritis in the rhesus monkey.

Abstract：

:The influence of cyclosporin A (CsA) on type II collagen-induced arthritis (CIA) in the rhesus monkey has been investigated. CsA was administered subcutaneously in a dose of 25 mg/kg per day during 9-18 days and additionally 12.5 mg/kg per day for 7 days. At this dosing regime no significant alterations of haematologic parameters were found, indicating that the toxicity of CsA was negligible. Administration of CsA after onset of arthritis had no beneficial effect, but when given between immunization and manifestation of clinical symptoms, CIA could be prevented completely. Moreover, these monkeys became resistant to the disease, because no arthritic activity could be observed upon a booster immunization with type II collagen (CII). The suppression of disease by CsA is reflected in reduced antibody levels to CII.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Bakker NP,Van Besouw N,Groenestein R,Jonker M,Hart LA

doi

10.1111/j.1365-2249.1993.tb08179.x

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

318-22

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

93

pub_type

杂志文章

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