Predominance of IgA deposits in glomeruli of Schistosoma mansoni infected mice.

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:It has been demonstrated immunohistologically using cryostat sections that the lectins PHA and Con A bind to human placentae. Both lectins stain trophoblastic basement membrane (TBM), perivascular tissue and stroma. No staining of trophoblasts was observed. It has been shown by blocking experiments that the lectin bin...

journal_title：Clinical and experimental immunology

authors： Johnson PM,Faulk WP

更新日期：1976-06-01 00:00:00

abstract：:Twenty-one patients with primary immunoglobulin deficiency were enrolled in a crossover study to test the efficacy and safety of Alphaglobin in comparison with the licensed preparations Sandoglobulin and Gamimune. There was no statistical difference in these parameters between Alphaglobin and Sandoglobulin/Gamimune. T...

journal_title：Clinical and experimental immunology

authors： Zuhrie SR,Webster AD,Davies R,Fay AC,Wallington TB

更新日期：1995-01-01 00:00:00

abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

journal_title：Clinical and experimental immunology

authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

更新日期：2005-07-01 00:00:00

abstract：:The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of ...

journal_title：Clinical and experimental immunology

authors： Lydyard PM,Isenberg D,de Sousa B,Mackenzie L,Cooke A

更新日期：1987-03-01 00:00:00

abstract：:Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

journal_title：Clinical and experimental immunology

authors： Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

更新日期：2002-10-01 00:00:00

abstract：:Supernatants of concanavalin A (Con A)-activated human spleen cells have been previously shown to inhibit polyclonal immunoglobulin (Ig) biosynthesis by pokeweed mitogen (PWM)-stimulated human spleen and peripheral blood mononuclear cells. In the present study, hydrocortisone was added at the beginning of in vitro cul...

journal_title：Clinical and experimental immunology

authors： Ilfeld D,Krakauer RS

更新日期：1982-04-01 00:00:00

abstract：:Recently, naturally occurring antibodies to IFN-alpha were discovered in a few systemic lupus erythematosus (SLE) and cancer patients; however, in most patients monitored for anti-IFN antibodies before treatment, no antibodies were found. In an attempt to explain the 'IFN-blocking effect' that we observed in all serum...

journal_title：Clinical and experimental immunology

authors： Ross C,Hansen MB,Schyberg T,Berg K

更新日期：1990-10-01 00:00:00

abstract：:Human thyroid epithelial cells (thyrocytes) express HLA Class II molecules in autoimmune thyroid diseases (ATD). Normal thyrocytes do not express Class II, but can be induced to do so by culture with interferon-gamma (gamma-IFN). We have examined HLA-D subregion expression in sections and monolayers of thyroid by indi...

journal_title：Clinical and experimental immunology

authors： Todd I,Pujol-Borrell R,Abdul-Karim BA,Hammond LJ,Feldmann M,Bottazzo GF

更新日期：1987-09-01 00:00:00

abstract：:In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the ...

journal_title：Clinical and experimental immunology

authors： Koenders MI,van den Berg WB

更新日期：2010-02-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:In a study of thirty-nine children with recurrent infections, circulating antigens, either free or in the form of immune complexes, were detected in thirty. The ability of sera to inhibit the agglutination of latex by rheumatoid factor or the C1q component of complement was used as a test for the presence of immune co...

journal_title：Clinical and experimental immunology

authors： Delire M,Masson PL

更新日期：1977-09-01 00:00:00

abstract：:We have previously found that isolated B-CLL cells from progressive disease produce less interleukin-1 beta (IL-1 beta) as compared with cells from patients with indolent disease. Here we extend that finding to include measurements of IL-1 beta mRNA and secretion of IL-1 alpha and interleukin-6 (IL-6). As before, a lo...

journal_title：Clinical and experimental immunology

authors： Aguilar-Santelises M,Magnusson R,Svenson SB,Loftenius A,Andersson B,Mellstedt H,Jondal M

更新日期：1991-06-01 00:00:00

abstract：:Mutations in the signal transducer and activator of transcription 3 (STAT3) were reported to cause hyperimmunoglobulin E syndrome (HIES). The present study investigates T helper type 17 (Th17) responses triggered by the relevant stimuli Staphylococcus aureus and Candidia albicans in five 'classical' HIES patients, and...

journal_title：Clinical and experimental immunology

authors： van de Veerdonk FL,Marijnissen RJ,Joosten LA,Kullberg BJ,Drenth JP,Netea MG,van der Meer JW

更新日期：2010-01-01 00:00:00

abstract：:Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

journal_title：Clinical and experimental immunology

authors： Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

更新日期：2003-09-01 00:00:00

abstract：:The aim of this study was to analyse and characterize immunoglobulins in CIC and serum from patients with anti-cardiolipin antibodies. CIC from five patients were isolated by gradient centrifugation and gel filtration. The distribution between serum and CIC of immunoglobulin reactivity against different phospholipids ...

journal_title：Clinical and experimental immunology

authors： Arfors L,Lefvert AK

更新日期：1997-04-01 00:00:00

abstract：:Ten sera from 48 patients with systemic sclerosis were found to be capable of producing cytotoxicity of human umbilical venous and arterial endothelium when co-cultured with peripheral blood mononuclear cells. Fractionation of sera on Ultrogel and the preparation of monomeric IgG by ion exchange and affinity chromatog...

journal_title：Clinical and experimental immunology

authors： Holt CM,Lindsey N,Moult J,Malia RG,Greaves M,Hume A,Rowell NR,Hughes P

更新日期：1989-12-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:In this study, we have evaluated the effects of cyclophosphamide on the development of experimental allergic encephalomyelitis (EAE) in four EAE rodent models: monophasic EAE in Lewis rats, protracted relapsing (PR)-EAE in DA rats, myelin oligodendrocyte protein (MOG)-induced EAE in C57Bl/6 mice and proteolipid protei...

journal_title：Clinical and experimental immunology

authors： Mangano K,Nicoletti A,Patti F,Donia M,Malaguarnera L,Signorelli S,Magro G,Muzio V,Greco B,Zaratin P,Meroni P,Zappia M,Nicoletti F

更新日期：2010-02-01 00:00:00

abstract：:In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

journal_title：Clinical and experimental immunology

authors： Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

更新日期：1990-12-01 00:00:00

abstract：:Splenectomized patients are highly susceptible to infections with capsulated bacteria and an impaired response to vaccination with bacterial polysaccharides has frequently been observed in these individuals. Based partly on experimental animal data, an important role for the spleen in the production of specific anti-c...

journal_title：Clinical and experimental immunology

authors： Hammarström L,Smith CI

更新日期：1986-11-01 00:00:00

abstract：:Listeria monocytogenes (Listeria) are known to grow and proliferate in the liver while a splenectomy induces host resistance against a Listeria infection despite the fact that a splenectomy inhibits the Th1 response. Therefore, the mechanism by which a splenectomy helps to prevent the growth of Listeria still remains ...

journal_title：Clinical and experimental immunology

authors： Kuranaga N,Kinoshita M,Kawabata T,Shinomiya N,Seki S

更新日期：2005-04-01 00:00:00

abstract：:The production in vitro of antibody to hepatitis B surface antigen by peripheral blood mononuclear cells of healthy volunteers was studied after each of the three doses of hepatitis B vaccine. An in vitro hepatitis B surface antigen antibody response was successfully induced in 12% of the specimens taken over a 7 mont...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R

更新日期：1988-12-01 00:00:00

abstract：:We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline...

journal_title：Clinical and experimental immunology

authors： Hull DN,Williams RO,Pathan E,Alzabin S,Abraham S,Taylor PC

更新日期：2015-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive B cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. Changes in the function and clonal diversity of T lymphocytes might be...

journal_title：Clinical and experimental immunology

authors： Cárdenas D,Vélez G,Orfao A,Herrera MV,Solano J,Olaya M,Uribe AM,Saavedra C,Duarte M,Rodríguez M,López M,Fiorentino S,Quijano S

更新日期：2015-11-01 00:00:00

abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

journal_title：Clinical and experimental immunology

authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

更新日期：1984-06-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:We have previously demonstrated enhanced synovial fluid (SF) antigen-presenting cell (APC) function in inflammatory arthritis patients selected on the basis of marked SF mononuclear cell (MNC) responsiveness to reactive arthritis-associated bacteria (Clin Exp Immunol 1990; 79:189-94). In this study we have assessed wh...

journal_title：Clinical and experimental immunology

authors： Viner NJ,Gaston JS,Bacon PA

更新日期：1993-05-01 00:00:00

abstract：:The expression and the functional role of the CD26 (1F7) T cell surface molecule, an ectoenzyme which seems to represent a functional collagen receptor of T lymphocytes and to have a role in T cell activation, were analysed in both peripheral blood (PB) and synovial fluid (SF) T cell samples from patients with active ...

journal_title：Clinical and experimental immunology

authors： Muscat C,Bertotto A,Agea E,Bistoni O,Ercolani R,Tognellini R,Spinozzi F,Cesarotti M,Gerli R

更新日期：1994-11-01 00:00:00

abstract：:The molecular basis of common variable immunodeficiency (CVID) is undefined, and diagnosis requires exclusion of other diseases including X-linked lymphoproliferative disease (XLP). This rare disorder of immunedysregulation presents typically after Epstein-Barr virus infection and results from defects in the SAP (SLAM...

journal_title：Clinical and experimental immunology

authors： Eastwood D,Gilmour KC,Nistala K,Meaney C,Chapel H,Sherrell Z,Webster AD,Davies EG,Jones A,Gaspar HB

更新日期：2004-09-01 00:00:00