Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis.

abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

journal_title：Clinical and experimental immunology

authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

更新日期：1986-04-01 00:00:00

abstract：:Autoantibodies characteristic for anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are anti-β2 -glycoprotein I (β2 GPI) antibodies and anti-DNA antibodies, respectively, and almost half of APS cases occur in SLE. Anti-β2 GPI antibodies are recognized to play a pivotal role in inducing a prothrom...

journal_title：Clinical and experimental immunology

authors： Virachith S,Saito M,Watanabe Y,Inoue K,Hoshi O,Kubota T

更新日期：2019-02-01 00:00:00

abstract：:Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

journal_title：Clinical and experimental immunology

authors： Löfdahl JM,Wahlström J,Sköld CM

更新日期：2006-09-01 00:00:00

abstract：:The tryptic FAD-peptide carrying the flavin in 8alpha-(N3)histidyl linkage as natural hapten was isolated by HPLC from the bacterial enzyme 6-hydroxy-d-nicotine oxidase. The same flavin protein linkage is found in the mitochondrial succinate dehydrogenase flavoprotein subunit, the predominant flavoprotein with covalen...

journal_title：Clinical and experimental immunology

authors： Cicek G,Schiltz E,Staiger J,Neumann FJ,Melchers I,Brandsch R

更新日期：2003-05-01 00:00:00

abstract：:The susceptibility genes for psoriasis remain to be identified. At least one of these must be in the major histocompatibility complex (MHC) to explain associations with alleles at human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and C4. In fact, most of these alleles are components of just two ancestral haplotypes (A...

journal_title：Clinical and experimental immunology

authors： Tay GK,Hui J,Gaudieri S,Schmitt-Egenolf M,Martinez OP,Leelayuwat C,Williamson JF,Eiermann TH,Dawkins RL

更新日期：2000-03-01 00:00:00

abstract：:Identification of autoimmune processes and introduction of new autoantigens involved in the pathogenesis of multiple sclerosis (MS) can be helpful in the design of new drugs to prevent unresponsiveness and side effects in patients. To find significant changes, we evaluated the autoantibody repertoires in newly diagnos...

journal_title：Clinical and experimental immunology

authors： Pazhouhandeh M,Sahraian MA,Siadat SD,Fateh A,Vaziri F,Tabrizi F,Ajorloo F,Arshadi AK,Fatemi E,Piri Gavgani S,Mahboudi F,Rahimi Jamnani F

更新日期：2018-04-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked platelet/immunodeficiency disease. The affected gene encodes WASP, a multidomain protein that regulates cytoskeletal assembly in blood cells. Patients have recurring infections, and their lymphocytes exhibit deficient proliferative responses in vitro. We report an evaluati...

journal_title：Clinical and experimental immunology

authors： Park JY,Kob M,Prodeus AP,Rosen FS,Shcherbina A,Remold-O'Donnell E

更新日期：2004-04-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in t...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-07-01 00:00:00

abstract：:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant suc...

journal_title：Clinical and experimental immunology

authors： Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

更新日期：1982-04-01 00:00:00

abstract：:In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

journal_title：Clinical and experimental immunology

authors： Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

更新日期：1990-12-01 00:00:00

abstract：:C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation. Attempts to demonstrate changes in C4BP plasma levels in systemic lupus erythematosus and essential mixed cryoglobulinaemia have failed, probably du...

journal_title：Clinical and experimental immunology

authors： Bergamaschini L,Miedico A,Cicardi M,Coppola R,Faioni EN,Agostoni A

更新日期：1999-05-01 00:00:00

abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

journal_title：Clinical and experimental immunology

authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

更新日期：1986-05-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:Lymphocyte and neutrophil locomotion were studied in 23 patients with well defined, primary immunodeficiencies. These included eight patients with common variable immune deficiency, three patients with X-linked agammaglobulinaemia, two patients with the Wiskott-Aldrich syndrome, three patients with ataxia telangiectas...

journal_title：Clinical and experimental immunology

authors： Van Epps DE,El-Naggar A,Ochs HD

更新日期：1983-09-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:Calculated globulin (total protein - albumin) is usually tested as part of a liver function test profile in both primary and secondary care and determines the serum globulin concentration, of which immunoglobulins are a major component. The main use hitherto of calculated globulin is to detect paraproteins when the le...

journal_title：Clinical and experimental immunology

authors： Jolles S,Borrell R,Zouwail S,Heaps A,Sharp H,Moody M,Selwood C,Williams P,Phillips C,Hood K,Holding S,El Shanawany T

更新日期：2014-09-01 00:00:00

abstract：:The sera of seven out of eight patients with Herpes gestationis contained a factor which fixed C3 but not detectable amounts of immunoglobulin (Ig) on the basement membrane zone (BMZ) of normal human skin. Using C2-deficient human serum and C4-deficient guinea-pig serum, fixation was shown to be dependent upon activat...

journal_title：Clinical and experimental immunology

authors： Carruthers JA,Ewins AR

更新日期：1978-01-01 00:00:00

abstract：:Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

journal_title：Clinical and experimental immunology

authors： Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

更新日期：1984-01-01 00:00:00

abstract：:Histamine (10(-3)-10(-8) M) inhibits PHA-induced proliferation of human peripheral blood lymphocytes (HPBL). Inhibition is detected at low concentrations of PHA but is rarely observed at high PHA concentrations. The histamine type II (H2) receptor agonists dimaprit, impromidine and 4-methylhistamine (4MH) inhibit HPBL...

journal_title：Clinical and experimental immunology

authors： Badger AM,Young J,Poste G

更新日期：1983-01-01 00:00:00

abstract：:The murine immune system is not necessarily identical to it human counterpart, which has led to the construction of humanized mice. The current study analysed whether or not a human immune system contained within the non-obese diabetic (NOD)-Rag1(null) -γ chain(null) (NRG) mouse model was an accurate representation of...

journal_title：Clinical and experimental immunology

authors： Harris DT,Badowski M,Balamurugan A,Yang OO

更新日期：2013-12-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:The aim of this study was to characterize the proinflammatory and T helper (Th)1/Th2 cytokine responses during acute parvovirus B19 (B19) infection and determine whether an imbalance of the Th1/Th2 cytokine pattern is related to persistent B19 infection. Cytokines were quantified by multiplex beads immunoassay in seru...

journal_title：Clinical and experimental immunology

authors： Isa A,Lundqvist A,Lindblom A,Tolfvenstam T,Broliden K

更新日期：2007-03-01 00:00:00

abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

journal_title：Clinical and experimental immunology

authors： Shiratsuchi H,Tsuyuguchi I

更新日期：1984-08-01 00:00:00

abstract：:Reliable risk assessment for biotherapeutics requires accurate evaluation of risk factors associated with immunogenicity. Immunogenicity risk assessment tools were developed and applied to investigate the immunogenicity of a fully human therapeutic monoclonal antibody, ATR-107 [anti-interleukin (IL)-21 receptor] that ...

journal_title：Clinical and experimental immunology

authors： Xue L,Hickling T,Song R,Nowak J,Rup B

更新日期：2016-01-01 00:00:00

abstract：:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

journal_title：Clinical and experimental immunology

authors： Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

更新日期：1984-12-01 00:00:00

abstract：:The X-linked lymphoproliferative syndrome (XLPS) is an immunodeficiency characterized by severe primary infection with the Epstein Barr (EB) virus, which is often fatal. This has been attributed to failure to generate T lymphocytes which are specifically cytotoxic for EB virus-infected B lymphocytes, and which develop...

journal_title：Clinical and experimental immunology

authors： Ando I,Morgan G,Levinsky RJ,Crawford DH

更新日期：1986-02-01 00:00:00

abstract：:The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

journal_title：Clinical and experimental immunology

authors： Shah T,Webster AD,Peters TJ

更新日期：1984-07-01 00:00:00

abstract：:Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are sti...

journal_title：Clinical and experimental immunology

authors： Kallenberg CG

更新日期：2011-05-01 00:00:00

abstract：:Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten ...

journal_title：Clinical and experimental immunology

authors： Hamblin TJ,Jones JV,Peacock DB

更新日期：1975-07-01 00:00:00