Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis.

Abstract:

:We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline 4 and 12 weeks after treatment, and Th17 cell frequencies were analysed using interleukin (IL)-17 enzyme-linked immunospot (ELISPOT) and flow cytometry. A significant increase in IL-17-producing cells was observed by ELISPOT in RA and AS patients at 12 weeks. Flow cytometry confirmed significant increases in CD4(+) IL-17(+) cells at 12 weeks in RA and AS and 4 weeks in PsA patients. Anti-TNF treatment increases circulating Th17 cells in three different diseases.

journal_name

Clin Exp Immunol

authors

Hull DN,Williams RO,Pathan E,Alzabin S,Abraham S,Taylor PC

doi

10.1111/cei.12626

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

401-6

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

181

pub_type

临床试验,杂志文章
  • Age-related autoantibody production in a nonhuman primate model.

    abstract::Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01454.x

    authors: Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

    更新日期:2001-03-01 00:00:00

  • Metabolomics analysis of saliva from patients with primary Sjögren's syndrome.

    abstract::The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12683

    authors: Kageyama G,Saegusa J,Irino Y,Tanaka S,Tsuda K,Takahashi S,Sendo S,Morinobu A

    更新日期:2015-11-01 00:00:00

  • High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130.

    abstract::We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02052.x

    authors: Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

    更新日期:2003-02-01 00:00:00

  • Specific activation of CD4- CD8- double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.

    abstract::Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and an...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12992

    authors: Passos LSA,Magalhães LMD,Soares RP,Marques AF,Nunes MDCP,Gollob KJ,Dutra WO

    更新日期:2017-10-01 00:00:00

  • Studies on the origin of the precursor cells in multiple myeloma, Waldenström's macroglobulinaemia and benign monoclonal gammopathy. I. Cytoplasmic isotype and idiotype distribution in peripheral blood and bone marrow.

    abstract::Lymphocytes and plasma cells in the peripheral blood and bone marrow of patients with multiple myeloma, benign monoclonal gammopathy and Waldenström's macroglobulinaemia were investigated for their cytoplasmic immunoglobulin distribution. Anti-idiotypic sera were used as markers for monoclonality. Double-wavelength fl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Van Camp B,Reynaert P,Broodtaerts L

    更新日期:1981-04-01 00:00:00

  • Hypogalactosylation of serum IgG in patients with coeliac disease.

    abstract::Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02220.x

    authors: Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

    更新日期:2003-09-01 00:00:00

  • Differences in modifications of cytoplasmic free Ca2+ concentration and 86Rb+ influx in human neoplastic B cells by antibodies to mu- relative to delta-Ig heavy chains.

    abstract::Cytoplasmic free Ca2+ concentration and influx of 86Rb+ (K+ analogue) were determined during the first minutes after stimulation of neoplastic human B cells and B cell lines by antibodies to surface Ig. The Ca2+ concentration increased in the great majority of samples (41 of 48). All of four B cell lines also responde...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Heikkilä R,Ruud E,Funderud S,Godal T

    更新日期:1985-03-01 00:00:00

  • Autoantibodies in recent onset type-1 diabetic patients to a Mr 60K microsomal hepatic protein: new evidence for autoantibodies to the type-2 glucose transporter.

    abstract::Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01366.x

    authors: Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

    更新日期:2000-11-01 00:00:00

  • Pharmacodynamics of recombinant human DNase I in serum.

    abstract::Recombinant human deoxyribonuclease I (rhDNase) may be an effective therapeutic for the treatment of systemic lupus erythematosus (SLE). The pharmacodynamics of rhDNase in serum was investigated using two activity assays: one based on hydrolysis of a radiolabelled phage DNA and the other based on hydrolysis of human c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00647.x

    authors: Prince WS,Baker DL,Dodge AH,Ahmed AE,Chestnut RW,Sinicropi DV

    更新日期:1998-08-01 00:00:00

  • Antisera to human IgE can also recognize IgA and IgM molecules as produced by selected B lymphoblastoid cell lines.

    abstract::A series of polyclonal and monoclonal anti-human IgE sera reacted with a panel of 11 selected IgA and IgM producing B lymphoblastoid cell lines (BLCLs) in cytoplasmic fluorescence, ELISA and immunoprecipitation assays. The reactions were discordant between the BLCLs and the individual antisera. The panel of 11 BLCLs w...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hendriks RW,Thompson A,Kraakman ME,Drayer AL,Schuurman RK

    更新日期:1988-11-01 00:00:00

  • Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12.

    abstract::Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01943.x

    authors: Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

    更新日期:2002-10-01 00:00:00

  • The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues.

    abstract::Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secre...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2010.04156.x

    authors: Yildirim NC,Yurekli M

    更新日期:2010-07-01 00:00:00

  • Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis.

    abstract::Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV ge...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/cei.12690

    authors: Russi S,Dammacco F,Sansonno S,Pavone F,Sansonno D

    更新日期:2015-12-01 00:00:00

  • Regulation of the in vitro monoclonal immunoglobulin production in cultures of peripheral blood mononuclear cells and bone marrow cells from myeloma patients mediated by T cell dependent mitogens.

    abstract::In vitro monoclonal immunoglobulin (mIg) production of cultured tumour cells--prepared from the bone marrow (BM) or from the peripheral blood (PB) of 40 multiple myeloma (MM) patients, 16 patients with monoclonal gammopathy of undetermined significance and two patients with M. Waldenström--was measured with an enzyme-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Peest D,Gasch S,Thiele C,Bartels B,Brunkhorst U,Dallmann I,Hoffmann M,Schedel I,Deicher H

    更新日期:1986-07-01 00:00:00

  • Viruses and type 1 diabetes: ignorance acquires a better vocabulary.

    abstract::The hypothesis that a virus might in some way be involved in the causation of type 1 diabetes has a long history, but decades of research have failed to resolve the issue beyond reasonable doubt. Viruses could potentially play a primary role in the pathogenesis of type 1 diabetes by initiating autoimmunity, a secondar...

    journal_title:Clinical and experimental immunology

    pub_type:

    doi:10.1111/j.1365-2249.2011.04553.x

    authors: Gale EA

    更新日期:2012-04-01 00:00:00

  • Inhibition of human monocyte Fc receptor and HLA-DR antigen expression by pregnancy alpha-2 glycoprotein.

    abstract::The precise factor responsible for the altered immunological reactivity and diminished inflammatory responses occurring in pregnancy is unknown. Recent observations implicate the pregnancy-associated alpha-2 glycoprotein (PAG). Using rosette assays for the detection of cells carrying Fc receptors and for the demonstra...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Persellin RH,Rhodes J

    更新日期:1981-11-01 00:00:00

  • Long-term immunological reconstitution by peripheral blood leucocytes in severe combined immune deficiency disease: implications for the role of mature lymphocytes in histocompatible bone marrow transplantation.

    abstract::A 7 month old girl with severe combined immunodeficiency disease (SCID) received a single transfusion of peripheral blood leucocytes from her histocompatible grandfather in an attempt to achieve immunological reconstitution. There was rapid restoration of humoral and cellular immunity which has persisted undiminished ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Polmar SH,Schacter BZ,Sorensen RU

    更新日期:1986-06-01 00:00:00

  • Virus-specific cytotoxic T cell responses are associated with immunity of the cottontop tamarin to Epstein-Barr virus (EBV).

    abstract::The cytotoxic responses of peripheral blood lymphocytes from cottontop tamarins to in vitro restimulation with autologous lymphoblastoid cell lines (LCL) were assayed. Lymphocytes from immune tamarins that had recovered from EBV challenge developed potent cytotoxicity for natural killer (NK) cell targets and for autol...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-607.x

    authors: Wilson AD,Shooshstari M,Finerty S,Watkins P,Morgan AJ

    更新日期:1996-02-01 00:00:00

  • Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors.

    abstract::PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Horst HJ,Flad HD

    更新日期:1987-04-01 00:00:00

  • Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells.

    abstract::Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03402.x

    authors: Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

    更新日期:2007-08-01 00:00:00

  • Relationships between humoral factors in HIV-1-infected mothers and the occurrence of HIV infection in their infants.

    abstract::Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb03840.x

    authors: Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

    更新日期:1995-12-01 00:00:00

  • Induction of autoimmune disease by graft-versus-host reaction across MHC class II difference: modification of the lesions in IL-6 transgenic mice.

    abstract::We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb07030.x

    authors: Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

    更新日期:1994-03-01 00:00:00

  • Transplantation tolerance: the big picture. Where do we stand, where should we go?

    abstract::A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three-stage tolerance-inducing strategy for transp...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12933

    authors: Waldmann H

    更新日期:2017-08-01 00:00:00

  • Development of antibodies to hepatitis B virus surface antigen in bone marrow transplant recipient following treatment with peripheral blood lymphocytes from immunized donors.

    abstract::Bone marrow transplantation (BMT) recipients are immunosuppressed and are at risk for contracting severe infections. Recently, adoptive transfer of immunity against hepatitis B virus (HBV) was documented in BMT recipients receiving bone marrow from 'naturally' HBV-infected individuals who recovered spontaneously, or t...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb06084.x

    authors: Ilan Y,Nagler A,Shouval D,Ackerstein A,Or R,Kapelushnik J,Adler R,Slavin S

    更新日期:1994-08-01 00:00:00

  • An efficient one-step method for isolating immune complexes from whole serum using a monoclonal anti-C3g affinity immunosorbent.

    abstract::A simple and efficient method of extracting complement-fixing immune complexes (IC) from whole serum and recovering them has been developed. 125I-labelled, in vitro prepared IC in whole serum were incubated with Sepharose 4B covalently linked to monoclonal anti-C3g or anti-C1q and the binding and recovery of IC was mo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Samuel DJ,Amlot PL,Shepherd P,Lachmann PJ

    更新日期:1986-08-01 00:00:00

  • Interactions of Mycobacterium lepraemurium with resident peritoneal macrophages; phagocytosis and stimulation of the oxidative burst.

    abstract::Live Mycobacterium lepraemurium or 60Co-gamma-irradiated organisms stimulated a very weak oxidative burst compared with similar numbers of heat-killed organisms or with live M. microti. This was found to reflect the poor uptake of the living organisms rather than an absolute failure to stimulate an oxidative burst. It...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Brett SJ,Butler R

    更新日期:1988-01-01 00:00:00

  • Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes.

    abstract::Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Ma DD,Ho AH,Hoffbrand AV

    更新日期:1984-02-01 00:00:00

  • Induction of unresponsiveness against IgA in IgA-deficient patients on subcutaneous immunoglobulin infusion therapy.

    abstract::Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Sera from three patients with common variable immunodeficiency (CVID) and one with a selective IgA deficiency with anti-IgA antibodies receiving subcutaneous gammagl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00571.x

    authors: Sundin U,Nava S,Hammarström L

    更新日期:1998-05-01 00:00:00

  • Characterization and demonstration of human liver-specific protein (LSP) and apo-LSP.

    abstract::Liver-specific protein (LSP) prepared by standard methods from five normal human livers showed significant variations in terms of quantitative yield, lipid/protein ratio and migration characteristics of different components on SDS-polyacrylamide gel electrophoresis. This heterogeneity is probably related to varying am...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Lebwohl N,Gerber MA

    更新日期:1981-11-01 00:00:00

  • Increased elastase secretion by peripheral blood monocytes in cystic fibrosis patients.

    abstract::Morbidity and mortality in cystic fibrosis (CF) is predominantly due to destruction of pulmonary tissue. The host immune response may, in part, play a pathogenic role in pulmonary destruction in these patients. To further understand host immune response in CF, we examined the state of activation of peripheral blood mo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb03290.x

    authors: Jones MM,Seilheimer DK,Pier GB,Rossen RD

    更新日期:1990-06-01 00:00:00