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Synovial fluid antigen-presenting cell function in rheumatoid arthritis.

Abstract：

:We have previously demonstrated enhanced synovial fluid (SF) antigen-presenting cell (APC) function in inflammatory arthritis patients selected on the basis of marked SF mononuclear cell (MNC) responsiveness to reactive arthritis-associated bacteria (Clin Exp Immunol 1990; 79:189-94). In this study we have assessed whether similarly enhanced synovial APC function is present in other inflammatory arthritis patients by using two assay systems to study 18 rheumatoid arthritis patients whose MNC responsiveness had not been determined in advance. We demonstrate that rheumatoid SF APC are much more potent than peripheral blood (PB) APC in stimulating the responses of autologous PB T cells to a range of recall antigens. In addition, SF APC are shown to be efficient stimulators of the antigen-specific responses of MHC-compatible, cloned T cells. Enhanced synovial APC function is thus likely to be a general feature of inflammatory arthritis and may play an important role in its pathogenesis.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Viner NJ,Gaston JS,Bacon PA

doi

10.1111/j.1365-2249.1993.tb03388.x

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

251-5

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

92

pub_type

杂志文章

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