Gamma/delta T cell subsets in patients with active Mycobacterium tuberculosis infection and tuberculin anergy.

abstract：:Natural killer (NK) cytotoxic activity was simultaneously investigated in bone marrow mononuclear cells (BMMC) and peripheral blood lymphocytes (PBL) from nine Hodgkin's disease (HD) and 15 non-Hodgkin lymphoma (NHL) untreated patients. Twenty-five PBL samples and seven bone marrow specimens from healthy individuals w...

journal_title：Clinical and experimental immunology

authors： Caldera LH,Leon-Ponte M,Acquatella G,Bianco NE,Blanca I

更新日期：1992-04-01 00:00:00

abstract：:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

journal_title：Clinical and experimental immunology

authors： Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

更新日期：2001-03-01 00:00:00

abstract：:Although the inhibitory effect of iron on macrophage production of tumoricidal free radical nitric oxide (NO) has been reported, its possible influence on macrophage anti-tumour activity has not been established. In the present study, FeSO4 markedly reduced IFN-gamma + LPS-induced NO synthesis in mouse and rat macroph...

journal_title：Clinical and experimental immunology

authors： Harhaji L,Vuckovic O,Miljkovic D,Stosic-Grujicic S,Trajkovic V

更新日期：2004-07-01 00:00:00

abstract：:We have studied the role of three mouse distinct non-H-2 genes (Bcg, Tbc-1, xid) in several phenomena of antituberculosis immunity and resistance. On the basis of median survival time (MST) of mice following infection with virulent Mycobacterium tuberculosis H37Rv, Bcg gene did not control resistance to the lethal dos...

journal_title：Clinical and experimental immunology

authors： Nikonenko BV,Apt AS,Mezhlumova MB,Avdienko VG,Yeremeev VV,Moroz AM

更新日期：1996-04-01 00:00:00

abstract：:One hundred and sixty-two unrelated, healthy normals and 118 unrelated SLE patients were subdivided by sex, race, and disease, and each group was in Hardy-Weinberg equilibrium for autosomal codominant expression of the four CR1 alleles. There were no significant phenotypic differences between males and females (P grea...

journal_title：Clinical and experimental immunology

authors： Van Dyne S,Holers VM,Lublin DM,Atkinson JP

更新日期：1987-06-01 00:00:00

abstract：:Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfu...

journal_title：Clinical and experimental immunology

authors： Sengar DP,Rashid A,Perelmutter L,Harris JE

更新日期：1975-05-01 00:00:00

abstract：:Autoantibodies to insulin are often the first autoantibodies detected in young children with type 1 diabetes and can be present before the onset of clinical diabetes. These autoantibodies and their epitopes are, however, not well characterized. We explored the use of monoclonal antibodies and their recombinant Fab as ...

journal_title：Clinical and experimental immunology

authors： Padoa CJ,Crowther NJ,Thomas JW,Hall TR,Bekris LM,Torn C,Landin-Olsson M,Ortqvist E,Palmer JP,Lernmark A,Hampe CS

更新日期：2005-06-01 00:00:00

abstract：:Antibodies to the major phenolic glycolipid purified from Mycobacterium leprae have been demonstrated previously in sera of leprosy but not tuberculosis patients using an ELISA. The major antigenic determinants on this molecule were investigated using antisera raised in rabbits to the purified glycolipid and with a po...

journal_title：Clinical and experimental immunology

authors： Brett SJ,Payne SN,Draper P,Gigg R

更新日期：1984-04-01 00:00:00

abstract：:Recent evidence has shown that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4+ T cells remains largely unknown. Here we first foun...

journal_title：Clinical and experimental immunology

authors： Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

更新日期：2018-02-01 00:00:00

abstract：:Twenty-seven per cent of atopic patients initially presenting with infantile eczema or hay fever were defective for yeast opsonization and 18% had low levels of C2; these deficiencies were mutually exclusive, suggesting that they are primary. Both defects were associated with each of four different atopic syndromes, s...

journal_title：Clinical and experimental immunology

authors： Turner MW,Mowbray JF,Harvey BA,Brostoff J,Wells RS,Soothill JF

更新日期：1978-11-01 00:00:00

abstract：:The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

journal_title：Clinical and experimental immunology

authors： Shah T,Webster AD,Peters TJ

更新日期：1984-07-01 00:00:00

abstract：:We have produced monoclonal antibodies (MoAb) to the Rb core and lipid A regions of Salmonella lipopolysaccharide (LPS) and have assessed their ability to inhibit LPS-mediated mitogenic responses in vitro, and to protect against LPS toxicity and lethal Salmonella infection in vivo. Monoclonal antibodies RC-8 and RC-16...

journal_title：Clinical and experimental immunology

authors： Ward DC,Michalek SM,McGhee JR

更新日期：1988-04-01 00:00:00

abstract：:The expression and the functional role of the CD26 (1F7) T cell surface molecule, an ectoenzyme which seems to represent a functional collagen receptor of T lymphocytes and to have a role in T cell activation, were analysed in both peripheral blood (PB) and synovial fluid (SF) T cell samples from patients with active ...

journal_title：Clinical and experimental immunology

authors： Muscat C,Bertotto A,Agea E,Bistoni O,Ercolani R,Tognellini R,Spinozzi F,Cesarotti M,Gerli R

更新日期：1994-11-01 00:00:00

abstract：:Complement activation may play an important role in renal injury associated with glomerular deposition of IgA immune complexes. The ability of naturally occurring human IgA immune complexes (IgA-IC) and covalently cross-linked human IgA oligomers (X-IgA) to activate complement were examined in vitro and in vivo. Large...

journal_title：Clinical and experimental immunology

authors： Imai H,Chen A,Wyatt RJ,Rifai A

更新日期：1988-09-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:The anti-EBV T cell response was studied in a severe combined immunodeficiency patient (PS) who received two transplants of fetal liver cells. His peripheral blood mononuclear cells (PBMC) were incubated with EBV and cultured during 15 days. Eleven colonies were derived from the T lymphocytes causing the regression of...

journal_title：Clinical and experimental immunology

authors： Plotnicky H,Touraine JL

更新日期：1993-12-01 00:00:00

abstract：:There is no information available about immunological interactions between the synovial tissue compartment and systemic immunity in health and in disease. The aim of the present study was to evaluate effects of intra-articular immunization on the systemic immune responses in humans. Control subjects were immunized wit...

journal_title：Clinical and experimental immunology

authors： Trollmo C,Carlsten H,Tarkowski A

更新日期：1990-11-01 00:00:00

abstract：:Peripheral blood mononuclear cells from 97 predominantly lepromatous leprosy patients and 11 control subjects were tested in a lymphoproliferative assay for response to Mycobacterium leprae (whole and sonicated), and sonicated M. vaccae, M. tuberculosis, and M. scrofulaceum, in the presence and absence of three types ...

journal_title：Clinical and experimental immunology

authors： Barnass S,Mace J,Steele J,Torres P,Gervasoni B,Ravioli R,Terencio J,Rook GA,Waters MF

更新日期：1986-04-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patients with SSc and hea...

journal_title：Clinical and experimental immunology

authors： Hong KH,Yoo SA,Kang SS,Choi JJ,Kim WU,Cho CS

更新日期：2006-11-01 00:00:00

abstract：:A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three-stage tolerance-inducing strategy for transp...

journal_title：Clinical and experimental immunology

authors： Waldmann H

更新日期：2017-08-01 00:00:00

abstract：:The high incidence of infections characteristic of impaired cell-mediated immunity in patients with hairy cell leukemia led us to study T lymphocyte function in sixteen patients with the lymphocyte transformation test. All patients showed imparied responses to mitogens, attributable to one or more of the following cau...

journal_title：Clinical and experimental immunology

authors： Sabbe LJ,Meijer CJ,Jansen J

更新日期：1980-11-01 00:00:00

abstract：:To gain some insight into the pathogenesis of proliferative lupus nephritis in MRL/lpr mice we investigated the kinetics of removal of immune complexes from the circulation, the carrier state of blood cells, the uptake of complexes by the mononuclear phagocyte system, and the localization of complexes in kidneys. In n...

journal_title：Clinical and experimental immunology

authors： Granholm NA,Cavallo T

更新日期：1990-11-01 00:00:00

abstract：:Low concentrations of protease and trypsin reduced the electrophoretic mobility (EPM) of thymocytes; with higher concentrations it was normal or above. Differences in membrane structure of thymocytes, T and B cells was found as B cells showed no reduction while T cells gave intermediate values. Further the reduction w...

journal_title：Clinical and experimental immunology

authors： Wiig JN

更新日期：1975-10-01 00:00:00

abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

journal_title：Clinical and experimental immunology

authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

更新日期：1995-12-01 00:00:00

abstract：:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations t...

journal_title：Clinical and experimental immunology

authors： Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

更新日期：2001-06-01 00:00:00

abstract：:Interleukin (IL)-22 is a cytokine involved in inflammatory and wound healing processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) expression is limited to epithelial cells of the digestive organs, respiratory tract and skin. Most tumours originating in these sites over-express...

journal_title：Clinical and experimental immunology

authors： Curd LM,Favors SE,Gregg RK

更新日期：2012-05-01 00:00:00

abstract：:Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and CCL26. Up-regulation of CCL11...

journal_title：Clinical and experimental immunology

authors： Günther C,Wozel G,Meurer M,Pfeiffer C

更新日期：2011-11-01 00:00:00

abstract：:Peripheral T lymphocytes from asymptomatic HBsAg carriers and hepatitis B (HB) immune (naturally acquired or vaccine induced) donors were induced into interleukin-2 (IL-2) secretion by plasma-derived HBsAg and the translational products of the S- and pre-S2+S gene of HB virus (HBV) in vitro. Biphasic time courses of I...

journal_title：Clinical and experimental immunology

authors： Sylvan SP,Hekkström UB

更新日期：1989-11-01 00:00:00

abstract：:Antibodies recognizing infliximab (IFX) may develop in a proportion of treated patients, leading to loss of response or hypersensitivity reactions (HRs). T cell response to IFX has been poorly investigated. This paper was addressed to detect IFX-specific T cells in treated patients with inflammatory diseases developin...

journal_title：Clinical and experimental immunology

authors： Vultaggio A,Petroni G,Pratesi S,Nencini F,Cammelli D,Milla M,Prignano F,Annese V,Romagnani S,Maggi E,Matucci A,ABIRISK Consortium.

更新日期：2016-12-01 00:00:00

abstract：:Protection against intracellular pathogens such as Mycobacterium leprae is critically dependent on the function of NK cells at early stages of the immune response and on Th1 cells at later stages. In the present report we evaluated the role of IL-18 and IL-13, two cytokines that can influence NK cell activity, in the ...

journal_title：Clinical and experimental immunology

authors： de la Barrera S,Finiasz M,Fink S,Ilarregui J,Aleman M,Olivares L,Franco MC,Pizzariello G,del Carmen Sasiain M

更新日期：2004-01-01 00:00:00