Circulating T cells to infliximab are detectable mainly in treated patients developing anti-drug antibodies and hypersensitivity reactions.

abstract：:Immunotherapy of murine autoimmune and allergic diseases by administration of peptides corresponding to the dominant T cell epitope is a reality. However, problems remain in applying this therapy to reduce antibody responses in humans. To overcome these difficulties, a preclinical system was developed to test the effe...

journal_title：Clinical and experimental immunology

authors： Jackson DJ,Elson CJ,Kumpel BM

更新日期：2004-08-01 00:00:00

abstract：:Parechymal cells (PC) were prepared by digestion of perfused, lavaged rat lung in a mixture of collagenase and DNase, and harvested on a discontinuous percoll gradient. The process yielded on average 1.0 X 10(8) viable cells/gram tissue. PC were pulsed with soluble antigen, and tested for their capacity to trigger ant...

journal_title：Clinical and experimental immunology

authors： Holt PG,Degebrodt A,O'Leary C,Krska K,Plozza T

更新日期：1985-12-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. The increase in serum IgE concentration is clearly measurable by day 4 after the first HgCl2 injection...

journal_title：Clinical and experimental immunology

authors： Macphee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2002-09-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are of crucial importance in immune regulation and response to microbial factors. In multiple sclerosis (MS), pDCs from peripheral blood showed an immature phenotype, but its role in susceptibility to MS is not determined. Because infectious diseases are established triggers of exac...

journal_title：Clinical and experimental immunology

authors： Bayas A,Stasiolek M,Kruse N,Toyka KV,Selmaj K,Gold R

更新日期：2009-09-01 00:00:00

abstract：:Organ-specific surface-reactive antibodies to viable human adrenal cell suspensions from adult or fetal glands were detected by indirect immunofluorescence (IFL) in 24 out of 28 idiopathic Addison's disease sera with adrenal cytoplasmic antibodies. Cell-surface reactions were also present in nine out of 10 cases of po...

journal_title：Clinical and experimental immunology

authors： Khoury EL,Hammond L,Bottazzo GF,Doniach D

更新日期：1981-07-01 00:00:00

abstract：:Ten sera from 48 patients with systemic sclerosis were found to be capable of producing cytotoxicity of human umbilical venous and arterial endothelium when co-cultured with peripheral blood mononuclear cells. Fractionation of sera on Ultrogel and the preparation of monomeric IgG by ion exchange and affinity chromatog...

journal_title：Clinical and experimental immunology

authors： Holt CM,Lindsey N,Moult J,Malia RG,Greaves M,Hume A,Rowell NR,Hughes P

更新日期：1989-12-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that suppresses several experimental autoimmune diseases. Here we report the effects of Linomide on experimental autoimmune neuritis (EAN), a CD4+ T cell-mediated animal model of acute Guillain-Barré syndrome (GBS) in humans. EAN induced in Lewis rats b...

journal_title：Clinical and experimental immunology

authors： Zhu J,Bai XF,Hedlund G,Björk J,Bakhiet M,Van Der Meide PH,Link H

更新日期：1999-01-01 00:00:00

abstract：:Using quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease. gamma delta T cell receptor (TCR)+ cells...

journal_title：Clinical and experimental immunology

authors： Olofsson K,Hellström S,Hammarström ML

更新日期：1996-11-01 00:00:00

abstract：:Humoral antibodies to tumour associated membrane antigens of cultured human breast cancer cell lines were studied using the immune adherence (IA) test. Sera from 353 post-operative breast cancer patients and from twenty-five patients immunized by allogeneic breast cancer cells were tested against the MDA-MB-436 cell l...

journal_title：Clinical and experimental immunology

authors： Higuchi M,Robinson DS,Cailleau R,Irie RF,Morton DL

更新日期：1980-01-01 00:00:00

abstract：:CD30 is a surface molecule which can be expressed by normal B and T lymphocytes. Our study focused on the CD30 expression and release compared with IL-4 expression as well as CD23-alpha/beta in peripheral blood mononuclear cells (PBMC) from atopic subjects and controls. Data showed a lack of CD30 mRNA expression in th...

journal_title：Clinical and experimental immunology

authors： Esnault S,Benbernou N,Lavaud F,Guenounou M

更新日期：1996-10-01 00:00:00

abstract：:The effects of various cytokines on synthesis and microheterogeneity of carbohydrate structure of alpha 1-proteinase inhibitor (PI) and alpha-fetoprotein (AFP) in the human hepatoma cell lines Hep 3B and Hep G2 were studied. In both lines, crude cytokine preparations from LPS-activated human monocytes (CM) and several...

journal_title：Clinical and experimental immunology

authors： Mackiewicz A,Schultz D,Mathison J,Ganapathi M,Kushner I

更新日期：1989-01-01 00:00:00

abstract：:Previous reports have defined the capacity of ragweed pollen extract (RWA) to activate human complement (C) in fluid phase through the classical pathway and have ascertained a strong correlation between the extent of complement activation and the severity of symptoms of allergic rhinoconjunctivitis during the ragweed ...

journal_title：Clinical and experimental immunology

authors： Hidvégi T,Berrens L,Varga L,Marañon F,Schmidt B,Kirschfink M,Füst G

更新日期：1997-04-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

journal_title：Clinical and experimental immunology

authors： Bloemena E,Weinreich S,Schellekens PT

更新日期：1990-06-01 00:00:00

abstract：:During blood-stage infection of mice with a lethal variant of Plasmodium yoelii, cells in both spleen and liver became activated to reach a peak at day 5. In mice protected by vaccination, activation was accelerated after infection. The most striking difference observed was in the 10-fold greater yield of infiltrating...

journal_title：Clinical and experimental immunology

authors： Taverne J,Rahman D,Dockrell HM,Alavi A,Leveton C,Playfair JH

更新日期：1987-12-01 00:00:00

abstract：:The circulating and cervical B cell responses to Chlamydia trachomatis plasmid protein pgp3 were characterized in children and adults with ocular or genital chlamydial infection using the enzyme-linked immunospot assay (ELISPOT) and ELISA. No pgp3-specific ASCs were detected in healthy controls, but predominantly IgA ...

journal_title：Clinical and experimental immunology

authors： Ghaem-Maghami S,Ratti G,Ghaem-Maghami M,Comanducci M,Hay PE,Bailey RL,Mabey DC,Whittle HC,Ward ME,Lewis DJ

更新日期：2003-06-01 00:00:00

abstract：:Diagnosis of perinatal infection in the newborn is difficult; there may be few clinical signs and current tests are slow or non-specific. Detection of organisms, antigen or specific antibody to common pathogens often requires repeat samples and does not give immediate results. Haematological parameters, although relie...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Flower R,Han P

更新日期：1998-07-01 00:00:00

abstract：:In vitro monoclonal immunoglobulin (mIg) production of cultured tumour cells--prepared from the bone marrow (BM) or from the peripheral blood (PB) of 40 multiple myeloma (MM) patients, 16 patients with monoclonal gammopathy of undetermined significance and two patients with M. Waldenström--was measured with an enzyme-...

journal_title：Clinical and experimental immunology

authors： Peest D,Gasch S,Thiele C,Bartels B,Brunkhorst U,Dallmann I,Hoffmann M,Schedel I,Deicher H

更新日期：1986-07-01 00:00:00

abstract：:The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12...

journal_title：Clinical and experimental immunology

authors： MacDonald TT,Hutchings P,Choy MY,Murch S,Cooke A

更新日期：1990-08-01 00:00:00

abstract：:The controlled induction of haemoxygenase-1 (HO-1), an enzyme that catabolizes haem, has been shown to reduce haem, preventing pathologies associated with haem toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a lo...

journal_title：Clinical and experimental immunology

authors： Ademolue TW,Amodu OK,Awandare GA

更新日期：2017-05-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

journal_title：Clinical and experimental immunology

authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

更新日期：2015-07-01 00:00:00

abstract：:Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel...

journal_title：Clinical and experimental immunology

authors： Jaleco AC,Covas MJ,Victorino RM

更新日期：1994-11-01 00:00:00

abstract：:Aspergillus fumigatus, a ubiquitous fungus, is implicated in the pathogenesis of a number of clinically different allergic diseases in man, including allergic bronchopulmonary aspergillosis. Peptide-based immunotherapy may offer an alternative treatment strategy for the management of allergic disease. The objective of...

journal_title：Clinical and experimental immunology

authors： Svirshchevskaya EV,Alekseeva L,Marchenko A,Viskova N,Andronova TM,Benevolenskii SV,Kurup VP

更新日期：2002-02-01 00:00:00

abstract：:In autoimmune diseases, mitogen-induced IL-2 production in vitro is generally considered to be diminished despite evidence of lymphoid hyperactivity in vivo. HgCl2 is known to cause T-dependent polyclonal B cell activation in Brown-Norway (BN) rats, resulting in autoimmune disease. We show here that the IL-2 producing...

journal_title：Clinical and experimental immunology

authors： Baran D,Lantz O,Dosquet P,Sfaksi A,Druet P

更新日期：1988-09-01 00:00:00

abstract：:Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

journal_title：Clinical and experimental immunology

authors： Löfdahl JM,Wahlström J,Sköld CM

更新日期：2006-09-01 00:00:00

abstract：:We report here the characterization and fine specificity of a human monoclonal IgM lambda reacting with double stranded DNA. The purified IgM and its Fab fragment bind to DNA in the Farr or Crithidia lucilae assays as well as in an immunoenzymatic test. In the latter case, binding was inhibited by native DNA, by DNA a...

journal_title：Clinical and experimental immunology

authors： Fermand JP,Danon F,Brouet JC

更新日期：1985-02-01 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is a chronic dermal complication that occurs usually after recovery from visceral leishmaniasis (VL). The disease manifests into macular, papular and/or nodular clinical types with mono- or polymorphic presentations. Here, we investigated differences in immunological response...

journal_title：Clinical and experimental immunology

authors： Kaushal H,Bras-Gonçalves R,Avishek K,Kumar Deep D,Petitdidier E,Lemesre JL,Papierok G,Kumar S,Ramesh V,Salotra P

更新日期：2016-07-01 00:00:00

abstract：:This study tested the hypothesis that pregnant female baboons exhibit increased levels of various inflammatory mediators in serum resulting from ligature-induced periodontitis, and that these profiles would relate to periodontal disease severity/extent in the animals. The animals were sampled at baseline (B), mid-preg...

journal_title：Clinical and experimental immunology

authors： Ebersole JL,Steffen MJ,Holt SC,Kesavalu L,Chu L,Cappelli D

更新日期：2010-12-01 00:00:00

abstract：:Tolerance to lipopolysaccharide (LPS) constitutes a stress adaptation, in which a primary contact with LPS results in a minimal response when a second exposure with the same stimulus occurs. However, active important defence mechanisms are mounted during the tolerant state. Our aim was to assess the contribution of po...

journal_title：Clinical and experimental immunology

authors： Landoni VI,Chiarella P,Martire-Greco D,Schierloh P,van-Rooijen N,Rearte B,Palermo MS,Isturiz MA,Fernández GC

更新日期：2012-04-01 00:00:00