Evaluation of cellular immunological responses in mono- and polymorphic clinical forms of post-kala-azar dermal leishmaniasis in India.

abstract：:Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are common diseases dependent on environmental factors that activate the immune system in unknown ways. Mannan is a group of polysaccharides common in the environment; they are potentially pathogenic, because at least some of them induce Ps-, PsA-...

journal_title：Clinical and experimental immunology

authors： Hagert C,Siitonen R,Li XG,Liljenbäck H,Roivainen A,Holmdahl R

更新日期：2019-06-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:We have evaluated lymphocyte subsets both quantitatively and functionally in children with nephrotic syndrome. Ten children had minimal change nephrotic syndrome (MCNS), seven had focal segmental glomerular sclerosis (FSGS) and four had recovered from MCNS. Two patients with FSGS had decreased OKT4+ cells and a decrea...

journal_title：Clinical and experimental immunology

authors： Herrod HG,Stapleton FB,Trouy RL,Roy S

更新日期：1983-06-01 00:00:00

abstract：:HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. A...

journal_title：Clinical and experimental immunology

authors： Boswell MT,Rowland-Jones SL

更新日期：2019-06-01 00:00:00

abstract：:The distribution and regulatory function of immunoglobulin (Ig) synthesis by monocytes were assessed using several monoclonal antibodies and a cell sorter in samples from 13 patients with multiple myeloma (MM) and nine patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly w...

journal_title：Clinical and experimental immunology

authors： Takeshita A

更新日期：1986-12-01 00:00:00

abstract：:Increasing evidence has demonstrated that the immune system closely interacts with other physiological systems, whose communications are mediated by circulating cytokines and hormones. The aim of our study was to test whether the number and cytolytic activity of NK cells in a group of relatively healthy Italian nonage...

journal_title：Clinical and experimental immunology

authors： Mariani E,Ravaglia G,Forti P,Meneghetti A,Tarozzi A,Maioli F,Boschi F,Pratelli L,Pizzoferrato A,Piras F,Facchini A

更新日期：1999-04-01 00:00:00

abstract：:Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV ge...

journal_title：Clinical and experimental immunology

authors： Russi S,Dammacco F,Sansonno S,Pavone F,Sansonno D

更新日期：2015-12-01 00:00:00

abstract：:Sarcoidosis is a multisystem disease of unknown etiology characterized by non-caseating granulomata, formed mainly from macrophages surrounded by lymphocytes and plasma cells. Using a novel method for the preparation of blood leucocytes for flow cytometry, we report increased expression of LeuCAMs (CD11/CD18) on perip...

journal_title：Clinical and experimental immunology

authors： Shakoor Z,Hamblin AS

更新日期：1992-10-01 00:00:00

abstract：:The sera of six patients infected with Trichinella spiralis were studied for the presence of circulating immune complexes (CIC). CIC were present in all six patients studied 1 month after infection. In two patients in whom serial serum samples were available, as clinical improvement occurred there was a decrease in th...

journal_title：Clinical and experimental immunology

authors： Géniteau M,Verroust PJ,Smith MD,Morel-Maroger L,Saimot G,Coulaud JP

更新日期：1977-10-01 00:00:00

abstract：:Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with ...

journal_title：Clinical and experimental immunology

authors： Zhu L,Aly M,Wang H,Karakizlis H,Weimer R,Morath C,Kuon RJ,Toth B,Ekpoom N,Opelz G,Daniel V

更新日期：2018-08-01 00:00:00

abstract：:Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most ...

journal_title：Clinical and experimental immunology

authors： Hildebrand F,Pape HC,Harwood P,Wittwer T,Krettek C,van Griensven M

更新日期：2004-11-01 00:00:00

abstract：:Delayed-type hypersensitivity (DTH) to a soluble Mycobacterium leprae skin test antigen (SML) was successfully induced in healthy volunteers following immunization with 2 X 10(8) killed armadillo-derived M. leprae. No better sensitization was obtained by a mixture of live BCG and killed M. leprae. The relative specifi...

journal_title：Clinical and experimental immunology

authors： Smelt AH,Rees RJ,Liew FY

更新日期：1981-06-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:Neutrophil phagocytosis and killing of Candida albicans were examined using a radiometric assay in 25 patients with insulin-dependent diabetes and 17 controls under various in vitro metabolic conditions. Glucose was present at 5, 10 and 50 mM, beta-hydroxybutyrate at 1, 5 and 20 mM and glucose with beta-hydroxybutyrat...

journal_title：Clinical and experimental immunology

authors： Wilson RM,Reeves WG

更新日期：1986-02-01 00:00:00

abstract：:We describe the usefulness of a fast (48-h) limiting dilution assay (LDA) for the enumeration of human alloreactive helper T lymphocytes (HTL) in the peripheral blood, in relation to histologically defined rejection grades after heart transplantation. HTL frequencies (HTLf) in pretransplant samples varied from patient...

journal_title：Clinical and experimental immunology

authors： Vaessen LM,Daane CR,Maat AP,Balk AH,Claas FH,Weimar W

更新日期：1999-12-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Ahern J,Liew CL,Hopkins P,Chambers DC,Reynolds PN,Holmes M

更新日期：2009-11-01 00:00:00

abstract：:We analysed the proportions of different microparticles (MPs) in plasma from patients with rheumatoid arthritis (RA), and assessed their relationship with disease activity/therapy and their in-vitro effect on proinflammatory cytokine release. Blood and urine samples were obtained from 55 patients with RA (24 untreated...

journal_title：Clinical and experimental immunology

authors： Viñuela-Berni V,Doníz-Padilla L,Figueroa-Vega N,Portillo-Salazar H,Abud-Mendoza C,Baranda L,González-Amaro R

更新日期：2015-06-01 00:00:00

abstract：:We have compared features of experimental thyroiditis in the Buffalo strain rat induced by neonatal thymectomy, immunization with rat thyroglobulin (Tg) and complete Freund's adjuvant, and subcutaneous administration of trypan blue or 3-methylcholanthrene. The disease produced by neonatal thymectomy resulted in signif...

journal_title：Clinical and experimental immunology

authors： Cohen SB,Weetman AP

更新日期：1987-07-01 00:00:00

abstract：:Fluorescent probes can monitor events in lymphocytes stimulated by mitogens and antigens. Early activation is associated with conformational changes in membrane macromolecules, and has been studied by measurement of fluorescence intensity or polarization of the membrane-localizing probes ANS, NPN, DPH and TMRITC. Subs...

journal_title：Clinical and experimental immunology

authors： Nairn RC,Rolland JM

更新日期：1980-01-01 00:00:00

abstract：:Antibodies to the major phenolic glycolipid purified from Mycobacterium leprae have been demonstrated previously in sera of leprosy but not tuberculosis patients using an ELISA. The major antigenic determinants on this molecule were investigated using antisera raised in rabbits to the purified glycolipid and with a po...

journal_title：Clinical and experimental immunology

authors： Brett SJ,Payne SN,Draper P,Gigg R

更新日期：1984-04-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPIV), a T cell enzyme, has been implicated in the regulation of lymphocyte proliferation in response to lectins and allogeneic cells. A sensitive fluorimetric assay has been established for the enzyme and used to investigate DPIV activity, kinetics and the subcellular localization in lymphocy...

journal_title：Clinical and experimental immunology

authors： Harland C,Shah T,Webster AD,Peters TJ

更新日期：1988-11-01 00:00:00

abstract：:Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperfusion injury was investigated in Ws/Ws rats. Autoperfused segments of the jejunum were e...

journal_title：Clinical and experimental immunology

authors： Andoh A,Kimura T,Fukuda M,Araki Y,Fujiyama Y,Bamba T

更新日期：1999-04-01 00:00:00

abstract：:Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

journal_title：Clinical and experimental immunology

authors： Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

更新日期：1998-11-01 00:00:00

abstract：:Serum specimens from 66 HIV-1-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-1: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and...

journal_title：Clinical and experimental immunology

authors： Quesnel A,Pozzetto B,Moja P,Grattard F,Lucht FR,Touraine JL,Gaudin OG,Genin C

更新日期：1993-02-01 00:00:00

abstract：:In patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA), synovial fluid mononuclear cells (SFMC) show proliferation to bacterial antigens that trigger ReA, i.e. Chlamydia, Yersinia, Campylobactor, Shigella and Salmonella species. We have shown previously that SFMC proliferate significantl...

journal_title：Clinical and experimental immunology

authors： Singh R,Shasany AK,Aggarwal A,Sinha S,Sisodia BS,Khanuja SP,Misra R

更新日期：2007-06-01 00:00:00

abstract：:We have isolated tumour-infiltrating lymphocytes (TIL) clones from a patient with renal cell cancer. The cloning frequency and the effector function were measured. No difference in cloning frequency (r2 = 0.97, frequency = 1:13) was observed between TIL expanded with allogeneic versus autologous feeder cells. Sixty-fo...

journal_title：Clinical and experimental immunology

authors： Gorter A,Krüse KM,Schrier PI,Fleuren GJ,van de Griend RJ

更新日期：1992-01-01 00:00:00

abstract：:Inspired by the advances presented at the Inflammation and Immune Resolution Plenary Session at the British Society for Immunology Congress, December 2017, in this issue of Clinical & Experimental Immunology we present a Review Series on Inflammation and Immune Resolution. Our selection ranges from an overview of curr...

journal_title：Clinical and experimental immunology

authors： Taams LS

更新日期：2018-07-01 00:00:00

abstract：:Progesterone, estradiol, testosterone, cortisol, and 11-desoxycortisol (compound S) were added to cultures of human lymphocytes stimulated with phytohaemagglutinin (PHA) and purified protein derivative (PPD). The immunosuppressive effect of cortisol was verified and the three sex-steroid hormones also were found to in...

journal_title：Clinical and experimental immunology

authors： Wyle FA,Kent JR

更新日期：1977-03-01 00:00:00

abstract：:A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Alvaro S,Triolo G,Giacomelli R

更新日期：2015-10-01 00:00:00