Analysis of the major antigenic determinants of the characteristic phenolic glycolipid from Mycobacterium leprae.

abstract：:Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal im...

journal_title：Clinical and experimental immunology

authors： The TH,Andersen HK,Spencer ES,Klein G

更新日期：1977-06-01 00:00:00

abstract：:We have developed CD4+, tetanus antigen-specific T cell clones that proliferate in the presence of tetanus antigen and autologous irradiated peripheral blood leucocytes (PBL) as antigen-presenting cells (APC). There have been several reports that T cells can present antigen themselves. We have used tetanus antigen-spe...

journal_title：Clinical and experimental immunology

authors： Chirmule N,Kalyanaraman VS,Slade H,Oyaizu N,Pahwa S

更新日期：1990-05-01 00:00:00

abstract：:In vitro inducible suppressor cell precursors were detected in the spleen of BALB/c but not in DBA/2 mice infected intraperitoneally with 10(8) Mycobacterium lepraemurium bacilli, thus suggesting that their development is genetically controlled. Two pairs of mouse strains congenic at the Ity/Lsh/Bcg locus (BALB/c-C.D2...

journal_title：Clinical and experimental immunology

authors： Gosselin D,Turcotte R,Lemieux S

更新日期：1994-05-01 00:00:00

abstract：:A hybridoma (FMC4) has been derived which secretes antibody showing selective reaction with human B lymphocytes, monocytes and some null lymphocytes. Few, if any, T lymphocytes in normal blood are stained, although stimulation of lymphocytes with PHA leads to an increase in the proportion of cells reacting with the hy...

journal_title：Clinical and experimental immunology

authors： Beckman IG,Bradley J,Brooks DA,Kupa A,McNamara PJ,Thomas ME,Zola H

更新日期：1980-06-01 00:00:00

abstract：:Human antibodies to the repeat regions of the Plasmodium falciparum asexual blood stage antigen Pf155/RESA interfere with parasite growth in vitro, but the significance in this respect of antibodies to non-repetitive epitopes is less clear. In this study the levels of antibodies to a non-repetitive part of Pf155/RESA ...

journal_title：Clinical and experimental immunology

authors： Siddique AB,Ahlborg N,Warsame M,Perlmann P,Berzins K

更新日期：1999-06-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

journal_title：Clinical and experimental immunology

authors： Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

更新日期：2002-08-01 00:00:00

abstract：:We have developed a panel of MoAbs against four separate but overlapping epitopes on endothelial cell (EC) vascular cell adhesion molecule-1 (VCAM-1). Two of the MoAbs (1G11 and 1E5) inhibited T cell adhesion to tumour necrosis factor (TNF)-activated EC, whilst two MoAbs (1.4C3 and 6D9) did not. Using these MoAbs we h...

journal_title：Clinical and experimental immunology

authors： Wellicome SM,Kapahi P,Mason JC,Lebranchu Y,Yarwood H,Haskard DO

更新日期：1993-06-01 00:00:00

abstract：:Normal T cells bearing receptors for the Fc portion of IgG that were incubated in anti-RNP or anti-DNA at the time of activation with phytohaemagglutinin showed different effects on this activation as determined by flow cytometric analysis of acridine orange stained cells. Incubation in anti-RNP caused an arrest in th...

journal_title：Clinical and experimental immunology

authors： Alarcón-Segovia D,Llorente L

更新日期：1983-05-01 00:00:00

abstract：:Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s...

journal_title：Clinical and experimental immunology

authors： Theus SA,Smulian AG,Sullivan DW,Walzer PD

更新日期：1997-08-01 00:00:00

abstract：:Studies of patients with active tuberculosis (TB) and infected healthy individuals have shown that interferon (IFN)-gamma is present in sites of Mycobacterium tuberculosis infection in comparable levels. This suggests that there is a deficiency in the macrophage response to IFN-gamma in TB patients. We used recombinan...

journal_title：Clinical and experimental immunology

authors： Esquivel-Solís H,Quiñones-Falconi F,Zarain-Herzberg A,Amieva-Fernández RI,López-Vidal Y

更新日期：2009-10-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) has been recognized to possess diverse non-immunological effects on epithelial cells such as cellular growth and differentiation. We have previously demonstrated that IFN-gamma suppressed thyroid-stimulating hormone (TSH)-stimulated thyroglobulin (TG) synthesis in human thyrocytes through ...

journal_title：Clinical and experimental immunology

authors： Kung AW,Ma L,Lau KS

更新日期：1992-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, local and systemic bone loss and a lack of compensatory bone repair. Fibroblast-like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA. An increasing body of evide...

journal_title：Clinical and experimental immunology

authors： Wehmeyer C,Pap T,Buckley CD,Naylor AJ

更新日期：2017-07-01 00:00:00

abstract：:Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

journal_title：Clinical and experimental immunology

authors： Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

更新日期：2002-03-01 00:00:00

abstract：:Oral immunization with 25 mg/day of ovalbumin resulted in a number of changes in non-specific immune responsiveness, including increases in antibody produced to T-dependent but not T-independent antigens and the abrogation of tolerance induced by both oral and intravenous routes. The effect was transient, sex- and str...

journal_title：Clinical and experimental immunology

authors： Stokes CR,Newby TJ,Bourne FJ

更新日期：1983-05-01 00:00:00

abstract：:To clarify immunological differences among patients with Graves' disease (GD) and Hashimoto's disease (HD) at various levels of severity, we examined the expression of the CD154 molecules on peripheral T cells, which regulate B cell activation, B cell differentiation, and T-cell survival. We found decreases in the int...

journal_title：Clinical and experimental immunology

authors： Watanabe M,Yamamoto N,Matsuzuka F,Miyauchi A,Iwatani Y

更新日期：2004-06-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:Clinical evidence implicates polymorphonuclear leucocytes in the pathogenesis of vasculitis in Kawasaki disease. We examined modulation of expression of adhesion molecules (CD11b and CD62L) on polymorphonuclear leucocytes and how this expression is related to serum cytokine concentrations. In 18 patients with Kawasaki...

journal_title：Clinical and experimental immunology

authors： Kobayashi T,Kimura H,Okada Y,Inoue Y,Kobayashi T,Shinohara M,Morikawa A

更新日期：2007-04-01 00:00:00

abstract：:Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses. T cell activation requires both Af-specific engagement of the T-cell-receptor as well as interaction of antigen indepe...

journal_title：Clinical and experimental immunology

authors： Barrios CS,Johnson BD,D Henderson J Jr,Fink JN,Kelly KJ,Kurup VP

更新日期：2005-11-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00

abstract：:The level and avidity of anti-DNA antibody in the serum of New Zealand Black/White (NZB/W F1) hybrid mice has been determined. The results show that there is an age and sex-related variation in the avidity of this antibody. In mice of both sexes, the avidity of circulating anti-DNA antibody increases up to 5 months of...

journal_title：Clinical and experimental immunology

authors： Steward MW,Katz FE,West NJ

更新日期：1975-07-01 00:00:00

abstract：:Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity in individuals with XLA was performed to characterize the relationship...

journal_title：Clinical and experimental immunology

authors： Gaspar HB,Lester T,Levinsky RJ,Kinnon C

更新日期：1998-02-01 00:00:00

abstract：:We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

journal_title：Clinical and experimental immunology

authors： Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

更新日期：1994-03-01 00:00:00

abstract：:Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be assessed accurately but it was clearly less than that against the classical pathway. The compound appears to bind strongl...

journal_title：Clinical and experimental immunology

authors： Doherty NS

更新日期：1981-02-01 00:00:00

abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

journal_title：Clinical and experimental immunology

authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

更新日期：2018-05-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137-26, that binds to the C5a moiety of human C5 and neutralizes the effects of C5a without interfering with C5 c...

journal_title：Clinical and experimental immunology

authors： Fung M,Lu M,Fure H,Sun W,Sun C,Shi NY,Dou Y,Su J,Swanson X,Mollnes TE

更新日期：2003-08-01 00:00:00

abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

journal_title：Clinical and experimental immunology

authors： Zanetti M,Bellon B,Verroust P,Druet P

更新日期：1980-10-01 00:00:00

abstract：:Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide ...

journal_title：Clinical and experimental immunology

authors： Lu HW,He GN,Ma H,Wang JK

更新日期：2010-06-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:Citrobacter rodentium is a murine pathogen that transiently colonizes the lumen of the large intestine. C. rodentium induces colitis, but the relative importance and temporal induction of the T helper type 17 (Th17) and regulatory T cell (T(reg)) pathways in protection from the infection and inflammation have not been...

journal_title：Clinical and experimental immunology

authors： Symonds EL,Riedel CU,O'Mahony D,Lapthorne S,O'Mahony L,Shanahan F

更新日期：2009-07-01 00:00:00