Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. II. A hybridoma secreting antibody against an antigen expressed by human B and null lymphocytes.

abstract：:To determine the role of chemokines in the pathogenesis of systemic sclerosis (SSc), we examined serum levels, spontaneous production by peripheral blood mononuclear cells (PBMC), and histological distribution in the affected skin, of MCP-1, MIP-1alpha and MIP-1beta in SSc patients. Serum levels of these chemokines we...

journal_title：Clinical and experimental immunology

authors： Hasegawa M,Sato S,Takehara K

更新日期：1999-07-01 00:00:00

abstract：:Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

更新日期：2007-02-01 00:00:00

abstract：:Twenty-seven per cent of atopic patients initially presenting with infantile eczema or hay fever were defective for yeast opsonization and 18% had low levels of C2; these deficiencies were mutually exclusive, suggesting that they are primary. Both defects were associated with each of four different atopic syndromes, s...

journal_title：Clinical and experimental immunology

authors： Turner MW,Mowbray JF,Harvey BA,Brostoff J,Wells RS,Soothill JF

更新日期：1978-11-01 00:00:00

abstract：:Epstein-Barr (EB) virus serology was correlated with the results of immunological investigations of three inherited immunodeficiency diseases, in an attempt to understand the immune mechanisms controlling EB virus infection. In nine patients with Wiskott-Aldrich syndrome (WAS), the constant lack of anti-EB virus assoc...

journal_title：Clinical and experimental immunology

authors： Vilmer E,Lenoir GM,Virelizier JL,Griscelli C

更新日期：1984-02-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:Bovine type II collagen administered to non-pregnant female DBA/1 mice caused arthritis in 55% of animals with a mean onset time of 70 days following immunization. Of collagen-treated females subsequently becoming syngeneically pregnant before the onset of arthritis, all developed the disease within 10 days of parturi...

journal_title：Clinical and experimental immunology

authors： Waites GT,Whyte A

更新日期：1987-03-01 00:00:00

abstract：:Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal im...

journal_title：Clinical and experimental immunology

authors： The TH,Andersen HK,Spencer ES,Klein G

更新日期：1977-06-01 00:00:00

abstract：:Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1...

journal_title：Clinical and experimental immunology

authors： Long Y,Zhao X,Liu C,Xia C,Liu C

更新日期：2020-10-01 00:00:00

abstract：:Using in situ hybridization, we analysed the immunoglobulin repertoire expressed by the B cells present in myasthenia gravis thymuses from four patients. B cells, mostly in activated state, were clustered in germinal centres, in which multiple isotypes were identified. A majority of cells expressed IgG as compared wit...

journal_title：Clinical and experimental immunology

authors： Guigou V,Emilie D,Berrih-Aknin S,Fumoux F,Fougereau M,Schiff C

更新日期：1991-02-01 00:00:00

abstract：:Lymphocyte transformation test has often been used as an in vitro test for nickel allergy. We have previously demonstrated the presence of nickel-reactive T cells in individuals with no history of allergic disease and with a negative patch test towards NiSO4. In this study, we show that this proliferative response was...

journal_title：Clinical and experimental immunology

authors： Lisby S,Hansen LH,Menn T,Baadsgaard O

更新日期：1999-08-01 00:00:00

abstract：:Transfer of contact sensitivity (CS) responses by immune lymphoid cells was the first finding that distinguished cellular from humoral immunity. CS has remained the most studied T cell reaction in vivo, and is the prototype for a variety of delayed-type hypersensitivity (DTH) responses. DTH in essence is the recruitme...

journal_title：Clinical and experimental immunology

authors： Askenase PW

更新日期：2001-09-01 00:00:00

abstract：:We recently separated a PG1828-encoded triacylated lipoprotein (Pg-LP), composed of two palmitoyl and one pentadecanoyl groups at the N-terminal of glycerocysteine from Porphyromonas gingivalis, a periodontopathic bacteria, and found that Pg-LP exhibited definite biological activities through Toll-like receptor (TLR) ...

journal_title：Clinical and experimental immunology

authors： Makimura Y,Asai Y,Taiji Y,Sugiyama A,Tamai R,Ogawa T

更新日期：2006-10-01 00:00:00

abstract：:Studies of patients with active tuberculosis (TB) and infected healthy individuals have shown that interferon (IFN)-gamma is present in sites of Mycobacterium tuberculosis infection in comparable levels. This suggests that there is a deficiency in the macrophage response to IFN-gamma in TB patients. We used recombinan...

journal_title：Clinical and experimental immunology

authors： Esquivel-Solís H,Quiñones-Falconi F,Zarain-Herzberg A,Amieva-Fernández RI,López-Vidal Y

更新日期：2009-10-01 00:00:00

abstract：:Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the time of the investigation the patients were without drug treatment. They had normal blood counts of eosinophils but on ...

journal_title：Clinical and experimental immunology

authors： Hällgren R,Feltelius N,Svenson K,Venge P

更新日期：1985-03-01 00:00:00

abstract：:A complete functional deficiency of C1q is described in a patient suffering from SLE. From reduced plasma C1 activity of the parents a hereditary trait was assumed. The defective C1q molecule was haemolytically inactive, did not bind to immune complexes, and was not recognized by the monocyte C1q receptor. C1 activity...

journal_title：Clinical and experimental immunology

authors： Kirschfink M,Petry F,Khirwadkar K,Wigand R,Kaltwasser JP,Loos M

更新日期：1993-11-01 00:00:00

abstract：:Recently we described the occurrence of B cells producing polyspecific natural IgM with anti-tumour specificity in the spleen of non-tumour-bearing individuals as well as in fetal organisms. Immunoprecipitation and 2-D electrophoresis showed the binding of such antibodies to a 55-kD (pI 6.0) membrane surface glycoprot...

journal_title：Clinical and experimental immunology

authors： Bohn J,Niemann B,Roggenbuck D,Döcke W,Jahn S

更新日期：1995-03-01 00:00:00

abstract：:It has been suggested that the immune system may be responsible for the destruction of insulin secreting cells in some types of diabetes. In order to test this hypothesis, we studied the consequences of immune-mediated reactions on the function of pancreatic islet cells in vitro. A model was set up in vitro where mous...

journal_title：Clinical and experimental immunology

authors： Boitard C,Saï P,Debray-Sachs M,Assan R,Hamburger J

更新日期：1984-03-01 00:00:00

abstract：:We have reported previously that the LAD-4 monoclonal antibody (mAb) directed against a fibronectin receptor (FNR) on RL-male-1 T lymphoma cells in BALB/c mice partially inhibited their migration to the liver. In the present study, we examined the mechanism by which another anti-FNR mAb, LAD-1, exerts its antitumourig...

journal_title：Clinical and experimental immunology

authors： Ito M,Omoto S,Kato Y,Hayashi T,Mori N,Fujii YR

更新日期：2005-07-01 00:00:00

abstract：:Presence of antibodies directed against replication protein A (RPA), a DNA binding protein complex composed of three subunits (RPA-70, RPA-32 and RPA-14) was investigated among patients with SLE and other autoimmune diseases using immunoblot analysis to RPA-70 and RPA-32 recombinant proteins. Anti-RPA antibodies were ...

journal_title：Clinical and experimental immunology

authors： Garcia-Lozano R,Wichmann I,Garcia A,Sanchez-Roman J,Gonzalez-Escribano F,Nuñez-Roldan A

更新日期：1996-01-01 00:00:00

abstract：:Inadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1beta-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediat...

journal_title：Clinical and experimental immunology

authors： Kim WU,Yoo SA,Min SY,Park SH,Koh HS,Song SW,Cho CS

更新日期：2006-06-01 00:00:00

abstract：:The alpha 7 nicotinic receptor is reportedly a key element in the cholinergic anti-inflammatory pathway. Because a prototypical ligand for this receptor is nicotine, we studied the in vivo human response to bacterial endotoxin or lipopolysaccharide (LPS) in the context of nicotine or placebo pretreatment. Twelve adult...

journal_title：Clinical and experimental immunology

authors： Wittebole X,Hahm S,Coyle SM,Kumar A,Calvano SE,Lowry SF

更新日期：2007-01-01 00:00:00

abstract：:Recombinant human deoxyribonuclease I (rhDNase) may be an effective therapeutic for the treatment of systemic lupus erythematosus (SLE). The pharmacodynamics of rhDNase in serum was investigated using two activity assays: one based on hydrolysis of a radiolabelled phage DNA and the other based on hydrolysis of human c...

journal_title：Clinical and experimental immunology

authors： Prince WS,Baker DL,Dodge AH,Ahmed AE,Chestnut RW,Sinicropi DV

更新日期：1998-08-01 00:00:00

abstract：:Two colour fluorescent staining using anti-Leu-1 and anti-B1 monoclonal antibodies has been combined with continuous flow microfluorimetry to analyse and isolate the T and B cell populations in B cell chronic lymphocytic leukaemia (B-CLL) patients. In Rai stage 0 patients two distinct B1 positive populations were dete...

journal_title：Clinical and experimental immunology

authors： Murphy JJ,Tooze J,Millard RE,Hudson L

更新日期：1987-06-01 00:00:00

abstract：:Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

journal_title：Clinical and experimental immunology

authors： de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

更新日期：2005-06-01 00:00:00

abstract：:XLA bone marrow samples were shown to contain B cells expressing IgM, and pre-B cells that express the mu-surrogate light chain (mu psiLC) complex, albeit at a reduced frequency to that found in normal bone marrow. Antibody ligation of mu heavy chain on these cells and an XLA B cell line did not induce a Ca2+ flux, wh...

journal_title：Clinical and experimental immunology

authors： Genevier HC,Callard RE

更新日期：1997-12-01 00:00:00

abstract：:B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tiss...

journal_title：Clinical and experimental immunology

authors： Uhlig H,Rutter G,Dernick R

更新日期：1985-10-01 00:00:00

abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

journal_title：Clinical and experimental immunology

authors： Van Leer EH,Moullier P,Ronco P,Verroust P

更新日期：1987-03-01 00:00:00

abstract：:Thyroid peroxidase purified from porcine thyroid (pTPO) was found to induce an experimental murine thyroiditis with genetic restriction which was very different from that induced by mouse thyroglobulin (mTg). C57BL/6 and C57BL/10 (both H-2b) were good responders for thyroiditis, whereas A/J (H-2a), BALB/c (H-2d), DBA/...

journal_title：Clinical and experimental immunology

authors： Kotani T,Umeki K,Hirai K,Ohtaki S

更新日期：1990-04-01 00:00:00

abstract：:CD45R0 (UCHL1), a member of leucocyte common antigen family, is expressed largely on previously activated or memory T cells. We examined CD45R0 expression of T cell subpopulations in patients with Epstein-Barr virus (EBV) induced infectious mononucleosis (IMN) as a sign of in vivo activation. Consistent with the notio...

journal_title：Clinical and experimental immunology

authors： Miyawaki T,Kasahara Y,Kanegane H,Ohta K,Yokoi T,Yachie A,Taniguchi N

更新日期：1991-03-01 00:00:00