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Antibodies against cytomegalovirus-induced early antigens (CMV-EA) in immunosuppressed renal-allograft recipients.

Abstract：

:Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal implantation all showed CMV-EA antibody rises. Two patients remained seronegative until 4 years after transplantation. Thus, in immunosuppressed patients, antibodies against CMV-EA remained a high titres during many years (4--8 years) after transplantation as distinct from the apparently transient nature in acutely infected previously healthy adults with CMV mononucleosis or post-perfusion syndrome. These results support the view that CMV-EA antibodies reflect an active viral proliferation in the host.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

The TH,Andersen HK,Spencer ES,Klein G

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

502-5

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

28

pub_type

杂志文章

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