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Hepatitis B surface antigen containing immune complexes occur in seronegative hepatocellular carcinoma patients.

Abstract：

:IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin solid phase assays in both HBsAg+ and HBsAg- groups of patients with primary hepatocellular carcinoma (HCC). No differences were observed between the two patient groups either in the levels of antigen non-specific and HBsAg specific complexes or in the immunoglobulin isotype in the complexes. The results show that HBsAg can occur in an IC form in the sera of patients classified as HBsAg- by sensitive commercial assays and provides evidence of a further association of hepatitis B virus (HBV) and HCC in antigen negative patients. Furthermore, the HBsAg IC in HCC patients differ from those in other HBV infected subjects in that they are preferentially detected by the Clq assay.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Brown SE,Howard CR,Steward MW,Ajdukiewicz AB,Whittle HC

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

355-9

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

55

pub_type

杂志文章

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