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Generation of interleukin-2-dependent T cell lines from synovial fluids in rheumatoid arthritis.

Abstract：

:Synovial fluids from rheumatoid arthritis (RA) patients were found to contain activated T lymphocytes that could be maintained as continuous T cell lines (CTCL) in the presence of the T cell growth factor, interleukin (IL)-2. The CTCL predominantly expressed the OKT8 phenotype and were Ia antigen positive. IL-2-dependent RA CTCL could be maintained in an active dividing state by the presence of RA synovial fluids, whereas IL-2-dependent CTCL from mitogen stimulated PBL failed to respond to the fluids, which were shown to contain IL-2. This suggested that RA CTCL exhibit unique properties not possessed by normal PBL CTCL. The CTCL generated from activated synovial T lymphocyte populations in RA may be used to assess the functions of these cells and their responses to regulatory factors.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Wilkins JA,Olivier SL,Warrington RJ

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

1-6

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

58

pub_type

杂志文章

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