Cytokine release and its modulation by dexamethasone in whole blood following exercise.

abstract：:The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of...

journal_title：Clinical and experimental immunology

authors： Xie LD,Gao Y,Li MR,Lu GZ,Guo XH

更新日期：2008-11-01 00:00:00

abstract：:Myeloid FcαRI, a receptor for immunoglobulin (Ig)A, mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent. Anti-inflammatory signalling is triggered by monomeric targeting using anti-FcαRI Fab or IgA ligand binding, which inhibits immune and n...

journal_title：Clinical and experimental immunology

authors： Watanabe T,Kanamaru Y,Liu C,Suzuki Y,Tada N,Okumura K,Horikoshi S,Tomino Y

更新日期：2011-11-01 00:00:00

abstract：:In addition to its activity as a metabolic hormone and a regulator of somatic growth, insulin-like growth factor-I (IGF-I) has cytokine-like activities on lymphoid cells. A 14-day infusion of recombinant human (rh)IGF-I increased lymphocyte numbers in all the peripheral lymphoid organs examined. This increase was appa...

journal_title：Clinical and experimental immunology

authors： Robbins K,McCabe S,Scheiner T,Strasser J,Clark R,Jardieu P

更新日期：1994-02-01 00:00:00

abstract：:Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therap...

journal_title：Clinical and experimental immunology

authors： Ivancic R,Iqbal H,deSilva B,Pan Q,Matrka L

更新日期：2020-02-01 00:00:00

abstract：:An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

journal_title：Clinical and experimental immunology

authors： Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

更新日期：2005-03-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) of normal human donors are spontaneously cytotoxic for certain tumour-derived and virus-infected target cells. This so-called natural killing (NK) can be augmented by the action of interferons (IFN) and by IFN-inducers. In this study, we have compared both endogenous and augme...

journal_title：Clinical and experimental immunology

authors： Neighbour PA,Grayzel AI,Miller AE

更新日期：1982-07-01 00:00:00

abstract：:CD5 is an antigen normally found on T cells and on a minority subpopulation of B cells in fetal spleen and tonsil and on the majority of cells in B-chronic lymphocytic leukaemia. Recent reports described the occurrence of large numbers of CD5-positive B cells in the peripheral blood after bone marrow transplantation (...

journal_title：Clinical and experimental immunology

authors： Drexler HG,Brenner MK,Wimperis JZ,Gignac SM,Janossy G,Prentice HG,Hoffbrand AV

更新日期：1987-06-01 00:00:00

abstract：:The guinea pig model of low-dose pulmonary tuberculosis has been used to study the pathogenesis of infection as well as the mechanisms of bacille Calmette-Guérin (BCG) vaccine-induced resistance. We investigated the function of lung cells from naive and BCG-vaccinated guinea pigs after enzymatic digestion of lung tiss...

journal_title：Clinical and experimental immunology

authors： Jeevan A,Majorov K,Sawant K,Cho H,McMurray DN

更新日期：2007-08-01 00:00:00

abstract：:The murine antibody response to porcine insulin is controlled by immune response genes of the major histocompatibility complex. Animals of the one haplotype (H-2d) produce specific antibodies to pork insulin, while animals of other haplotypes do not. We analysed the antibody responses to purified pork insulin by anima...

journal_title：Clinical and experimental immunology

authors： Strayer DS,Kapp J

更新日期：1982-01-01 00:00:00

abstract：:Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin, ICAM-1, VCAM-1 and E-selectin are of particular interest. However, only thrombomodulin showed the expected close correlation. ...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Raeth U,Scherbaum WA,Galle PR,Stremmel W

更新日期：2000-01-01 00:00:00

abstract：:The supernatants of hybrids produced by fusion of splenocytes from normal, germ free, nude and neonatal BALB/c mice with mouse NS-1 myeloma cells were examined for immunofluorescence reactivity with viable and acetone fixed monolayers of syngeneic mouse fibroblasts and mouse 3T3 cells and with viable cell suspensions ...

journal_title：Clinical and experimental immunology

authors： Underwood JR,Pedersen JS,Chalmers PJ,Toh BH

更新日期：1985-05-01 00:00:00

abstract：:Interspecies immunization of marmosets with platelets leads to an acute thrombocytopenia which appears to be immunologically mediated. The thrombocytopenia is preceded by the formation of antibodies to the donor platelet antigen and deposition of IgG on the host's platelets. Examination of sera obtained from these ani...

journal_title：Clinical and experimental immunology

authors： Gengozian N,Annostby D

更新日期：1981-01-01 00:00:00

abstract：:Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

journal_title：Clinical and experimental immunology

authors： Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

更新日期：2001-10-01 00:00:00

abstract：:Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since ch...

journal_title：Clinical and experimental immunology

authors： Nilsson E,Thomsen P,Ericson L,Palmblad J

更新日期：1995-10-01 00:00:00

abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

journal_title：Clinical and experimental immunology

authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

更新日期：1979-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

journal_title：Clinical and experimental immunology

authors： Yao QY,Rickinson AB,Gaston JS,Epstein MA

更新日期：1986-05-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 +/- 0.8 years) were found to have HIV antibodies and there was a significant increase (P less than 0.01) in the frequency of HIV antibody positivi...

journal_title：Clinical and experimental immunology

authors： Fernandez-Cruz E,Fernandez AM,Gutierrez C,Garcia-Montes M,de la Morena MT,Rodriguez-Villanueva J,Longo N,Zabay JM

更新日期：1988-05-01 00:00:00

abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

journal_title：Clinical and experimental immunology

authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

更新日期：1986-05-01 00:00:00

abstract：:One approach to study the role of distinct cellular mechanisms in susceptibility/resistance to tuberculosis (TB) is to compare parameters of response to infection in the lungs of mouse strains exhibiting genetically determined differences in TB susceptibility/severity. Interstrain differences in antimycobacterial macr...

journal_title：Clinical and experimental immunology

authors： Eruslanov EB,Majorov KB,Orlova MO,Mischenko VV,Kondratieva TK,Apt AS,Lyadova IV

更新日期：2004-01-01 00:00:00

abstract：:Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

journal_title：Clinical and experimental immunology

authors： Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

更新日期：1997-05-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

journal_title：Clinical and experimental immunology

authors： Shiratsuchi H,Tsuyuguchi I

更新日期：1984-08-01 00:00:00

abstract：:Ten out of 14 rhesus monkeys developed arthritis after a single immunization with bovine type II collagen (B-CII). In contrast to primary resistant monkeys, arthritic animals showed a B-CII specific T cell proliferation during the induction phase of the disease. All surviving animals showed a full remission of the dis...

journal_title：Clinical and experimental immunology

authors： Bakker NP,van Erck MG,'t Hart LA,Jonker M

更新日期：1991-11-01 00:00:00

abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

journal_title：Clinical and experimental immunology

authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

更新日期：2018-05-01 00:00:00

abstract：:CD4 monoclonal antibody (MoAb) was able to inhibit T cell proliferation induced in an autologous mixed lymphocyte reaction (AMLR). The effect of CD4 MoAb on cellular proliferation appears to be directly exerted on CD4+ T lymphocytes, and to be due to inhibition of a post-activation event, since the CD4+ T cell prolife...

journal_title：Clinical and experimental immunology

authors： Sakane T,Takada S

更新日期：1989-02-01 00:00:00

abstract：:Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone d...

journal_title：Clinical and experimental immunology

authors： Young DG,Skibinski G,Mason JI,James K

更新日期：1999-09-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:To clarify the differential state of B cell activation in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we investigated the expression of low-affinity receptor for IgE (Fc epsilon RII; CD23) on their peripheral B cells by a cytofluorometry using H107 (CD23) and Leu-16 (CD20) monoclona...

journal_title：Clinical and experimental immunology

authors： Kumagai S,Ishida H,Iwai K,Tsubata T,Umehara H,Ozaki S,Suginoshita T,Araya S,Imura H

更新日期：1989-12-01 00:00:00