The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-beta1) levels in normal healthy blood donors.

abstract：:Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137-26, that binds to the C5a moiety of human C5 and neutralizes the effects of C5a without interfering with C5 c...

journal_title：Clinical and experimental immunology

authors： Fung M,Lu M,Fure H,Sun W,Sun C,Shi NY,Dou Y,Su J,Swanson X,Mollnes TE

更新日期：2003-08-01 00:00:00

abstract：:Monocyte and macrophage dysfunction may be important for both immunopathogenesis and clinical manifestations in subgroups of patients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different me...

journal_title：Clinical and experimental immunology

authors： Aukrust P,Müller F,Frøland SS

更新日期：1994-08-01 00:00:00

abstract：:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antib...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Kataaha PK,Holborow EJ

更新日期：1989-08-01 00:00:00

abstract：:CD4 monoclonal antibody (MoAb) was able to inhibit T cell proliferation induced in an autologous mixed lymphocyte reaction (AMLR). The effect of CD4 MoAb on cellular proliferation appears to be directly exerted on CD4+ T lymphocytes, and to be due to inhibition of a post-activation event, since the CD4+ T cell prolife...

journal_title：Clinical and experimental immunology

authors： Sakane T,Takada S

更新日期：1989-02-01 00:00:00

abstract：:We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4+CD8+ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of thes...

journal_title：Clinical and experimental immunology

authors： Hirao J,Sugita K

更新日期：1998-02-01 00:00:00

abstract：:Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays ...

journal_title：Clinical and experimental immunology

authors： Mallone R,Mannering SI,Brooks-Worrell BM,Durinovic-Belló I,Cilio CM,Wong FS,Schloot NC,T-Cell Workshop Committee, Immunology of Diabetes Society.

更新日期：2011-01-01 00:00:00

abstract：:IFN-gamma is known to be a major inhibitor of IgE synthesis in vitro. Recent studies demonstrating reduced production of IFN-gamma in children and adults with atopic dermatitis and elevated serum IgE suggest a similar role for this cytokine in vivo. The reasons for this reduced IFN-gamma production are not known. One ...

journal_title：Clinical and experimental immunology

authors： Tang M,Kemp A

更新日期：1994-01-01 00:00:00

abstract：:Recent evidence has suggested that IgA1-containing macromolecules and the glycosylation of IgA1 in sera from patients with IgAN might involve the pathogenesis of IgAN. However, whether the different histological phenotypes can be attributed or not to the aberrant glycosylation of macromolecular IgA1 has not yet been e...

journal_title：Clinical and experimental immunology

authors： Xu LX,Yan Y,Zhang JJ,Zhang Y,Zhao MH

更新日期：2005-12-01 00:00:00

abstract：:To determine the role of chemokines in the pathogenesis of systemic sclerosis (SSc), we examined serum levels, spontaneous production by peripheral blood mononuclear cells (PBMC), and histological distribution in the affected skin, of MCP-1, MIP-1alpha and MIP-1beta in SSc patients. Serum levels of these chemokines we...

journal_title：Clinical and experimental immunology

authors： Hasegawa M,Sato S,Takehara K

更新日期：1999-07-01 00:00:00

abstract：:Cell-bound helper and suppressor factors, on lymphocytes from Rhesus monkeys, were assayed by the indirect immunofluorescent method, using F(ab')2 fragments of rabbit antisera to antigen specific secreted helper and suppressor factors. The rabbit antisera recognize the function related to the 'constant' region of secr...

journal_title：Clinical and experimental immunology

authors： Lehner T,Lamb JR,Kontiainen S

更新日期：1982-03-01 00:00:00

abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

journal_title：Clinical and experimental immunology

authors： Zanetti M,Bellon B,Verroust P,Druet P

更新日期：1980-10-01 00:00:00

abstract：:The spontaneous lysis of target cells sensitive to natural killer (NK) activity is accomplished in two distinct phases: (i) binding between target and effector cells and (ii) post-binding events leading to target cell destruction. To test the hypothesis that cell surface carbohydrate(s) might be involved in recognitiv...

journal_title：Clinical and experimental immunology

authors： Vose BM,Harding M,White W,Moore M,Gallagher J

更新日期：1983-03-01 00:00:00

abstract：:Using the natural killer (NK) sensitive K562 cell line, enhanced NK cell cytotoxicity was demonstrable early in the course of acute hepatitis B while normal values were obtained in patients studied during convalescence. No evidence of enhanced NK activity was instead obtained in the course of acute non-A, non-B hepati...

journal_title：Clinical and experimental immunology

authors： Chemello L,Mondelli M,Bortolotti F,Schiavon E,Pontisso P,Alberti A,Rondanelli EG,Realdi G

更新日期：1986-04-01 00:00:00

abstract：:The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by th...

journal_title：Clinical and experimental immunology

authors： Ritchie AW,James K,Micklem HS

更新日期：1983-03-01 00:00:00

abstract：:Lung cancer is strongly associated with cigarette smoking. More than 20 lung carcinogens have been identified in cigarette smoke and one of the most abundant is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). We hypothesized that NNK modulates alveolar macrophage (AM) mediator production, thus contributing to ca...

journal_title：Clinical and experimental immunology

authors： Therriault MJ,Proulx LI,Castonguay A,Bissonnette EY

更新日期：2003-05-01 00:00:00

abstract：:In vivo anti-nuclear antibody (ANA) was observed by direct immunofluorescence microscopy in epithelial cell nuclei in forty-four biopsies from thirty-three patients. The tissue containing the ANA was macroscopically normal in twenty-seven patients. The thirty-three patients with in vivo biopsy ANA included twenty-thre...

journal_title：Clinical and experimental immunology

authors： Wells JV,Webb J,Van Deventer M,Fry B,Pollard KM,Raftos J,Monk W,Nelson DS

更新日期：1979-12-01 00:00:00

abstract：:The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and...

journal_title：Clinical and experimental immunology

authors： Nalbandian A,Crispín JC,Tsokos GC

更新日期：2009-08-01 00:00:00

abstract：:Four human B cell lines with a mature phenotype (immunoglobulin secretion and expression of membrane markers associated with maturation) were cultured in the presence of phorbol ester (PMA), dimethyl sulphoxide (DMSO) and two conditioned media. PMA and DMSO led to changes in phenotype which suggested the cells were be...

journal_title：Clinical and experimental immunology

authors： Zola H,Griffith V,Hunter I,Koh L,Bradley J

更新日期：1986-11-01 00:00:00

abstract：:Previous findings have indicated that the major surface molecule of Leishmania, lipophosphoglycan (LPG), could abrogate HIV-1-induced syncytium formation and virus replication. In the present work, we were interested in characterizing this inhibitory process. Data from a new luciferase-based semiquantitative assay for...

journal_title：Clinical and experimental immunology

authors： Genois N,Barbeau B,Olivier M,Tremblay MJ

更新日期：2001-04-01 00:00:00

abstract：:Glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits (GOMMID) and glomerulonephritis related to type I cryoglobulin are well-known but rare complications of B cell derived chronic lymphocytic leukaemia. In these disorders, monoclonal Ig have never been studied at the molecular level. We co...

journal_title：Clinical and experimental immunology

authors： Galea HR,Bridoux F,Aldigier JC,Paraf F,Bordessoule D,Touchard G,Cogné M

更新日期：2002-07-01 00:00:00

abstract：:In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

journal_title：Clinical and experimental immunology

authors： Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

更新日期：1991-11-01 00:00:00

abstract：:One approach to study the role of distinct cellular mechanisms in susceptibility/resistance to tuberculosis (TB) is to compare parameters of response to infection in the lungs of mouse strains exhibiting genetically determined differences in TB susceptibility/severity. Interstrain differences in antimycobacterial macr...

journal_title：Clinical and experimental immunology

authors： Eruslanov EB,Majorov KB,Orlova MO,Mischenko VV,Kondratieva TK,Apt AS,Lyadova IV

更新日期：2004-01-01 00:00:00

abstract：:In patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA), synovial fluid mononuclear cells (SFMC) show proliferation to bacterial antigens that trigger ReA, i.e. Chlamydia, Yersinia, Campylobactor, Shigella and Salmonella species. We have shown previously that SFMC proliferate significantl...

journal_title：Clinical and experimental immunology

authors： Singh R,Shasany AK,Aggarwal A,Sinha S,Sisodia BS,Khanuja SP,Misra R

更新日期：2007-06-01 00:00:00

abstract：:Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells (DC) as antigen-presenting cells (APC) but requires a relatively high vo...

journal_title：Clinical and experimental immunology

authors： Zhu F,Ramadan G,Davies B,Margolis DA,Keever-Taylor CA

更新日期：2008-02-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation (HTx). Tolerance-inducing effects of ECP such as up-regulation of regulatory T cells (T(regs)) are known, but specific effects of ECP on regulatory T cell (T(reg)) subsets ...

journal_title：Clinical and experimental immunology

authors： Dieterlen MT,Bittner HB,Pierzchalski A,Dhein S,Mohr FW,Barten MJ

更新日期：2014-04-01 00:00:00

abstract：:Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. Under both situations, the lipid profile is characterized by accumulation of triglyceride-rich lipoproteins (TGRLs). This lipid profile is recognized as a risk factor for...

journal_title：Clinical and experimental immunology

authors： Saja MF,Cook HT,Ruseva MM,Szajna M,Pickering MC,Woollard KJ,Botto M

更新日期：2018-06-01 00:00:00

abstract：:We set out to discover whether antibodies to small ribonucleoprotein antigens (RNP) and to 73-kD heat shock protein (hsp 73) which have been proposed as markers of mixed connective tissue disease (MCTD) recognize different epitopes. MCTD serum was immunoadsorbed on hsp 73-coupled Sepharose and the affinity retained, a...

journal_title：Clinical and experimental immunology

authors： Appelboom T,Kahn MF,Mairesse N

更新日期：1995-06-01 00:00:00

abstract：:The proliferative response of preparations of whole PBMC populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days. PPD produced a classical secondary response in bo...

journal_title：Clinical and experimental immunology

authors： Ponsford M,Mazza G,Coad J,Campbell MJ,Zajicek J,Wraith DC

更新日期：2001-05-01 00:00:00

abstract：:Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-gamma) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believ...

journal_title：Clinical and experimental immunology

authors： Katagiri K,Itami S,Hatano Y,Takayasu S

更新日期：1997-05-01 00:00:00

abstract：:The presence of autoantibodies detected by immunofluorescence to single endocrine cells, of human duodenum is described in three groups of patients and two control groups. Of 173 coeliac cases, four had GIP cell antibodies, one had secretin cell antibodies and twenty-one reacted with both cell types. Of twelve tropica...

journal_title：Clinical and experimental immunology

authors： Mirakian R,Bottazzo GF,Doniach D

更新日期：1980-07-01 00:00:00