Abstract:
:We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4+CD8+ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of these 11 patients were complicated with coronary artery lesion (CAL); the 13 patients with normal numbers of CD4+CD8+ T lymphocytes did not have CAL. The patients' age, sex and grade of systemic inflammation evaluated by peripheral leucocyte count and serum C-reactive protein levels were not correlated to the number of CD4+CD8+ T lymphocytes. Other cell surface antigen characteristics of the CD4+CD8+ T lymphocytes included CD3+, CD45RA+, CD45RO+, CD16-, and HLA-DR+. These results indicate that the surface antigen characteristics of the KD peripheral blood examined were the same as those of Epstein-Barr virus infection without CD45RA+. These findings provide useful information for the analysis of the pathogenesis of KD.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Hirao J,Sugita Kdoi
10.1046/j.1365-2249.1998.00480.xsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
397-401issue
2eissn
0009-9104issn
1365-2249journal_volume
111pub_type
杂志文章abstract::Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...
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journal_title:Clinical and experimental immunology
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doi:
更新日期:1984-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
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doi:
更新日期:1978-11-01 00:00:00
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doi:
更新日期:1989-11-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
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doi:
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journal_title:Clinical and experimental immunology
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doi:
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doi:
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doi:
更新日期:1975-10-01 00:00:00
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doi:
更新日期:1983-11-01 00:00:00
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journal_title:Clinical and experimental immunology
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doi:
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pub_type: 杂志文章
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