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Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis.

Abstract：

:Secretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specific for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN), 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membranous nephropathy (MGN) and 40 healthy controls. Secretory IgA levels were elevated in both saliva and serum of patients with primary glomerulonephritis (P < 0.05; Mann-Whitney test) regardless of the histological type of the primary glomerulonephritis. Salivary IgA1 and IgA2 levels were increased in the saliva of patients with IgAGN, INS and MGN (P < 0.05; Mann-Whitney test). The monomeric/total IgA ratio, and interferon-gamma and soluble IL-2 receptor levels, in saliva did not differ between the patients and controls (P > 0.05; Mann-Whitney test). We conclude that the mucosal immune system is activated in forms of glomerulonephritis other than IgAGN.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Rostoker G,Terzidis H,Petit-Phar M,Meillet D,Lang P,Dubert JM,Lagrue G,Weil B

doi

10.1111/j.1365-2249.1992.tb07947.x

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

305-11

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

90

pub_type

杂志文章

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