Abstract：
:This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of oral epithelial cells had a significantly enhanced T cell co-stimulatory capacity compared to skin epithelial cells. This applied both to cultures with concanavalin A (con-A)-stimulated syngeneic T cells and to a mixed epithelial cell lymphocyte reaction involving allogeneic T cells. The co-stimulatory capacity of oral and skin epithelial cells was reduced by >70% if monoclonal antibodies against HLA-DR, -DP and -DQ were added to the cultures with allogeneic T cells, indicating the involvement of HLA class II expressing LC. Immunohistochemistry revealed that 6% of the epithelial cells were CD1a + LC in sections from both oral and skin epithelium. Interleukin (IL)-8 production was higher in cultures of oral epithelial cells and con-A stimulated T cells than in corresponding cultures with skin epithelial cells as accessory cells. The results suggest that LC in human oral epithelium are more efficient at stimulating T cells than those of skin.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Hasséus B,Jontell M,Bergenholtz G,Dahlgren UIdoi
10.1111/j.1365-2249.2004.02469.xsubject
Has Abstractpub_date
2004-06-01 00:00:00pages
483-9issue
3eissn
0009-9104issn
1365-2249pii
CEI2469journal_volume
136pub_type
杂志文章abstract：:Experiments to evaluate the effect of the level and duration of endotoxaemia on the meningeal inflammatory response were performed in order to determine if systemic inflammation alters meningitis. Rabbits received either saline or Escherichia coli O111:B4 lipopolysacharide (LPS) intravenously at various doses (1, 3 or...
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2249.1994.tb06611.x
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2249.1996.14723.x
更新日期：1996-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1365-2249.2001.01625.x
更新日期：2001-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2249.1995.tb03799.x
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journal_title：Clinical and experimental immunology
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doi：
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1981-02-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1985-08-01 00:00:00
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doi：
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
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journal_title：Clinical and experimental immunology
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