Autoantibody to gp50, a glycoprotein shared in common between fibroblasts and lymphocytes, in progressive systemic sclerosis.

abstract：:Patients with chronic granulomatous disease (CGD) suffer from recurrent, life-threatening bacterial and fungal infections of the skin, the airways, the lymph nodes, liver, brain and bones. Frequently found pathogens are Staphylococcus aureus, Aspergillus species, Klebsiella species, Burkholderia cepacia and Salmonella...

journal_title：Clinical and experimental immunology

authors： Roos D,de Boer M

更新日期：2014-02-01 00:00:00

abstract：:In this study, we aimed to explore the effects of imatinib on the proliferation of rheumatoid arthritis synovial cell (RA-FLS) and inflammatory responses by regulating CSF1R. Differential genes were screened via microarray analysis, followed by being analysed through the weighted co-expression network (WGCNA) network,...

journal_title：Clinical and experimental immunology

authors： Hu X,Tang J,Hu X,Bao P,Pan J,Ou Y,Deng W,Liang Y

更新日期：2019-02-01 00:00:00

abstract：:Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of unde...

journal_title：Clinical and experimental immunology

authors： Sfikakis PP,Oglesby R,Sfikakis P,Tsokos GC

更新日期：1994-04-01 00:00:00

abstract：:Superantigens (SAgs) are potent stimulators of T cells bearing specific Vbeta T cell receptors (TCR) and may play a role in the pathogenesis of Kawasaki syndrome (KS), although despite 15 years of intense study this area remains controversial. Because SAgs can cause Vbeta restricted T cell activation in the absence of...

journal_title：Clinical and experimental immunology

authors： Brogan PA,Shah V,Clarke LA,Dillon MJ,Klein N

更新日期：2008-02-01 00:00:00

abstract：:In a previous work we have demonstrated that in patients exhibiting a late allergic reaction (LAR), alveolar macrophages (AM) collected 18 h after bronchial allergen challenge produced high levels of IL-6 and tumour necrosis factor-alpha (TNF) which is known to up-regulate the endothelial cell expression of adhesion m...

journal_title：Clinical and experimental immunology

authors： Lassalle P,Gosset P,Delneste Y,Tsicopoulos A,Capron A,Joseph M,Tonnel AB

更新日期：1993-10-01 00:00:00

abstract：:The relation of clinical and laboratory findings at the time clinical presentation to subsequent survival was investigated in 204 patients with macroglobulinaemia. It was found that the ten following clinical and laboratory parameters were of prognostic significance and a further twelve were not. The best prognoses we...

journal_title：Clinical and experimental immunology

authors： Carter P,Koval JJ,Hobbs JR

更新日期：1977-05-01 00:00:00

abstract：:The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc...

journal_title：Clinical and experimental immunology

authors： Buckley C,Ivison C,Poulter LW,Rustin MH

更新日期：1993-03-01 00:00:00

abstract：:Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the per...

journal_title：Clinical and experimental immunology

authors： Fakunle YM,Oduloju AJ,Greenwood BM

更新日期：1978-08-01 00:00:00

abstract：:In reactive arthritis (ReA) there is specific proliferation of synovial fluid (SF) mononuclear cells (MNC) to the triggering bacterial antigen; comparatively little or no response is seen in peripheral blood (PB). To investigate the mechanism of this elevated local immune response, we examined patients with typical Re...

journal_title：Clinical and experimental immunology

authors： Sieper J,Braun J,Wu P,Kingsley G

更新日期：1993-01-01 00:00:00

abstract：:During chronic inflammation, interleukin (IL)-22 expression is up-regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL-22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolation, in humans. It ...

journal_title：Clinical and experimental immunology

authors： Yang GX,Sun Y,Tsuneyama K,Zhang W,Leung PS,He XS,Ansari AA,Bowlus C,Ridgway WM,Gershwin ME

更新日期：2016-08-01 00:00:00

abstract：:Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits that consist mainly of immunoglobulin (Ig)G and complement. Most of the cases are primary or idiopathic (iMN), while only approximately 25% of the cases are secondary to s...

journal_title：Clinical and experimental immunology

authors： Sinico RA,Mezzina N,Trezzi B,Ghiggeri GM,Radice A

更新日期：2016-02-01 00:00:00

abstract：:Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed 'antibody-independent' C activation. In an attempt to clarify these disparate findings, we inve...

journal_title：Clinical and experimental immunology

authors： Saarloos MN,Lint TF,Spear GT

更新日期：1995-02-01 00:00:00

abstract：:Cell death and the release of chromatin have been demonstrated to activate the immune system producing autoantibodies against nuclear antigens in patients with systemic lupus erythematosus (SLE). Apoptosis, necrosis, necroptosis, secondary necrosis, autophagy and the clearance of dying cells by phagocytosis are proces...

journal_title：Clinical and experimental immunology

authors： Fenton K

更新日期：2015-01-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00

abstract：:Lewis rats were immunized with bee venom allergen in Freund's complete adjuvant (FCA) or with FCA only. Animals immunized with bee venom developed specific IgG antibodies but no specific IgE antibodies were detected. Lymphocytes from lymph nodes when cultured with antigen in vitro showed an increased stimulation index...

journal_title：Clinical and experimental immunology

authors： Schneider H,Urbanek R

更新日期：1984-08-01 00:00:00

abstract：:Seeking better immunological markers indicating the long-term outcome of cystic echinococcosis (CE) after chemotherapy we studied 23 patients receiving albendazole, clinically followed for 8 years, and grouped ultrasonographically according to therapeutic outcome. Antibody responses against a partially purified fracti...

journal_title：Clinical and experimental immunology

authors： Riganò R,Ioppolo S,Ortona E,Margutti P,Profumo E,Ali MD,Di Vico B,Teggi A,Siracusano A

更新日期：2002-09-01 00:00:00

abstract：:Previous studies using isolated complement proteins have shown that more C4A than C4B binds to certain types of immune complexes. However, the in vivo binding of the C4 isoforms to an immune complex has not been investigated in detail and may differ from events when measured with the isolated proteins. We report here ...

journal_title：Clinical and experimental immunology

authors： Reilly BD

更新日期：1999-07-01 00:00:00

abstract：:Although the inhibitory effect of iron on macrophage production of tumoricidal free radical nitric oxide (NO) has been reported, its possible influence on macrophage anti-tumour activity has not been established. In the present study, FeSO4 markedly reduced IFN-gamma + LPS-induced NO synthesis in mouse and rat macroph...

journal_title：Clinical and experimental immunology

authors： Harhaji L,Vuckovic O,Miljkovic D,Stosic-Grujicic S,Trajkovic V

更新日期：2004-07-01 00:00:00

abstract：:Perivascular infiltrates of inflammatory cells are a hallmark of lesional skin in scleroderma. We have explored the potential for scleroderma fibroblasts to modulate mononuclear leucocyte migration across endothelial cell monolayers in tissue culture, and to regulate expression of endothelial cell adhesion molecules. ...

journal_title：Clinical and experimental immunology

authors： Denton CP,Shi-Wen X,Sutton A,Abraham DJ,Black CM,Pearson JD

更新日期：1998-11-01 00:00:00

abstract：:Perforin, one of the cytotoxic proteins of the immune system, plays a prominent role in protection against viral and bacterial infections. We investigated its expression in PBL and their CD3+, CD4+, CD8+ and CD16+ and/or CD56+ subpopulations in endurance athletes before and after a triathlon. Lymphocyte subpopulations...

journal_title：Clinical and experimental immunology

authors： Staats R,Balkow S,Sorichter S,Northoff H,Matthys H,Luttmann W,Berg A,Virchow JC

更新日期：2000-06-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Ahern J,Liew CL,Hopkins P,Chambers DC,Reynolds PN,Holmes M

更新日期：2009-11-01 00:00:00

abstract：:Lymphocytes isolated from Graves' and Hashimoto thyroid tissue by enzymatic (dispase) digestion or mechanical disaggregation were markedly different in terms of their ability to synthesize thyroid autoantibodies in culture. Dispase digestion, followed by removal of thyroid follicular cells, gave a lymphocyte populatio...

journal_title：Clinical and experimental immunology

authors： McLachlan SM,Pegg CA,Atherton MC,Middleton SL,Dickinson A,Clark F,Proctor SJ,Proud G,Rees Smith B

更新日期：1986-08-01 00:00:00

abstract：:Sixteen healthy adults had serial studies of delayed-type skin test reactivity and in vitro lymphocyte blastogenesis to several antigens over a period of 7 months. In many subjects blastogenesis varied broadly from month to month without apparent cause. Responses to all antigens usually increased or decreased together...

journal_title：Clinical and experimental immunology

authors： Graybill JR,Alford RH

更新日期：1976-07-01 00:00:00

abstract：:Our study aimed to determine the functional activity of different osteoclast progenitor (OCP) subpopulations and signals important for their migration to bone lesions, causing local and systemic bone resorption during the course of collagen-induced arthritis in C57BL/6 mice. Arthritis was induced with chicken type II ...

journal_title：Clinical and experimental immunology

authors： Ikić Matijašević M,Flegar D,Kovačić N,Katavić V,Kelava T,Šućur A,Ivčević S,Cvija H,Lazić Mosler E,Kalajzić I,Marušić A,Grčević D

更新日期：2016-12-01 00:00:00

abstract：:Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0....

journal_title：Clinical and experimental immunology

authors： Mathur S,Peress MR,Williamson HO,Youmans CD,Maney SA,Garvin AJ,Rust PF,Fudenberg HH

更新日期：1982-11-01 00:00:00

abstract：:Intraepithelial lymphocytes (IELs) can be identified among epithelial cells in systemic mucosal tissues. Although intestinal IELs play a crucial role in mucosal immunity, their bronchial counterparts have not been well studied. The purpose of this study was to determine the immunological functions of human bronchial I...

journal_title：Clinical and experimental immunology

authors： Hirosako S,Goto E,Fujii K,Tsumori K,Hirata N,Tsumura S,Kamohara H,Kohrogi H

更新日期：2009-02-01 00:00:00

abstract：:The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT ...

journal_title：Clinical and experimental immunology

authors： Zhang Y,Gao Y,Li M,Xie L,Huang Y,Gao Y,Guo X

更新日期：2010-07-01 00:00:00

abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

journal_title：Clinical and experimental immunology

authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

更新日期：1993-07-01 00:00:00

abstract：:Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of...

journal_title：Clinical and experimental immunology

authors： Su W,Du L,Liu S,Deng J,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2018-07-01 00:00:00

abstract：:Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

journal_title：Clinical and experimental immunology

authors： Facer CA,Bray RS,Brown J

更新日期：1979-01-01 00:00:00