Humoral and cellular immune response of the rat to immunization with bee venom.

abstract：:The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of ...

journal_title：Clinical and experimental immunology

authors： Lydyard PM,Isenberg D,de Sousa B,Mackenzie L,Cooke A

更新日期：1987-03-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably initiated by environmental factors, this disease takes place in genetically predisposed indivi...

journal_title：Clinical and experimental immunology

authors： Barcala Tabarrozzi AE,Castro CN,Dewey RA,Sogayar MC,Labriola L,Perone MJ

更新日期：2013-02-01 00:00:00

abstract：:The relation of clinical and laboratory findings at the time clinical presentation to subsequent survival was investigated in 204 patients with macroglobulinaemia. It was found that the ten following clinical and laboratory parameters were of prognostic significance and a further twelve were not. The best prognoses we...

journal_title：Clinical and experimental immunology

authors： Carter P,Koval JJ,Hobbs JR

更新日期：1977-05-01 00:00:00

abstract：:An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

journal_title：Clinical and experimental immunology

authors： Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

更新日期：1997-07-01 00:00:00

abstract：:Supernatants of both CD4+ and CD8+ alloreactive T cell clones induced IgM, IgG and IgA synthesis by peripheral blood lymphocytes (PBL) of healthy donors in vitro. These supernatants were also tested on their capacity to induce immunoglobulin production by PBL of four patients with CVI and one patient with CVI and thym...

journal_title：Clinical and experimental immunology

authors： Pastorelli G,Roncarolo MG,Touraine JL,Rousset F,Pene J,de Vries JE

更新日期：1989-12-01 00:00:00

abstract：:Evidence is emerging that exposure to mercury (Hg) may elicit many pathological manifestations, including immunomodulation. We tested whether changing cellular activation pathways may affect the immunomodulation by Hg. Human cell cultures were set up where isolated peripheral blood mononuclear cells, activated by mono...

journal_title：Clinical and experimental immunology

authors： Hemdan NY,Lehmann I,Wichmann G,Lehmann J,Emmrich F,Sack U

更新日期：2007-05-01 00:00:00

abstract：:Experiments to evaluate the effect of the level and duration of endotoxaemia on the meningeal inflammatory response were performed in order to determine if systemic inflammation alters meningitis. Rabbits received either saline or Escherichia coli O111:B4 lipopolysacharide (LPS) intravenously at various doses (1, 3 or...

journal_title：Clinical and experimental immunology

authors： O'Reilly T,Ostergaard C,Vaxelaire J,Zak O

更新日期：2007-01-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and...

journal_title：Clinical and experimental immunology

authors： Nalbandian A,Crispín JC,Tsokos GC

更新日期：2009-08-01 00:00:00

abstract：:Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-mic...

journal_title：Clinical and experimental immunology

authors： Rivas-Santiago CE,Rivas-Santiago B,León DA,Castañeda-Delgado J,Hernández Pando R

更新日期：2011-04-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of inflammation in ...

journal_title：Clinical and experimental immunology

authors： Obermeier F,Dunger N,Strauch UG,Grunwald N,Herfarth H,Schölmerich J,Falk W

更新日期：2003-11-01 00:00:00

abstract：:Tissue transglutaminase (tTG) seems to be the target self-antigen for endomysial antibodies in coeliac disease (CD) and to catalyse the critical deamidation of gliadin which strengthens its recognition by HLA-restricted gut-derived T cells. To date, it has not been demonstrated whether gliadin is cross-linked to tTG w...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Ara C,Biagi F,Perilli M,Amicosante G,Cifone MG,Corazza GR

更新日期：2003-12-01 00:00:00

abstract：:The susceptibility genes for psoriasis remain to be identified. At least one of these must be in the major histocompatibility complex (MHC) to explain associations with alleles at human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and C4. In fact, most of these alleles are components of just two ancestral haplotypes (A...

journal_title：Clinical and experimental immunology

authors： Tay GK,Hui J,Gaudieri S,Schmitt-Egenolf M,Martinez OP,Leelayuwat C,Williamson JF,Eiermann TH,Dawkins RL

更新日期：2000-03-01 00:00:00

abstract：:Neopterin is primarily synthesized and released by activated macrophages/monocytes upon stimulation with interferon-γ and is considered as a marker for macrophage activation. This study aimed to analyze the serum levels of neopterin in patients with dermatomyositis (DM) in association with clinical manifestations, lab...

journal_title：Clinical and experimental immunology

authors： Peng QL,Zhang YM,Liang L,Liu X,Ye LF,Yang HB,Zhang L,Shu XM,Lu X,Wang GC

更新日期：2020-03-01 00:00:00

abstract：:Inadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1beta-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediat...

journal_title：Clinical and experimental immunology

authors： Kim WU,Yoo SA,Min SY,Park SH,Koh HS,Song SW,Cho CS

更新日期：2006-06-01 00:00:00

abstract：:L-selectin in one of the key members of the selectin family of adhesion molecules and initiates leucocyte attachment to specialized high endothelial venules. The shed form, which retains functional activity, can be detected in biological fluids and is increased in diseases of many kinds. In the present study, we inves...

journal_title：Clinical and experimental immunology

authors： Zhang JG,Morgan L,Spickett GP

更新日期：1996-05-01 00:00:00

abstract：:Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-gamma) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believ...

journal_title：Clinical and experimental immunology

authors： Katagiri K,Itami S,Hatano Y,Takayasu S

更新日期：1997-05-01 00:00:00

abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

journal_title：Clinical and experimental immunology

authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

更新日期：1979-11-01 00:00:00

abstract：:Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. We conducted an observational study to identify SAD in children with recurrent respiratory infections. Ninety-nine children,...

journal_title：Clinical and experimental immunology

authors： Ruuskanen O,Nurkka A,Helminen M,Viljanen MK,Käyhty H,Kainulainen L

更新日期：2013-05-01 00:00:00

abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

journal_title：Clinical and experimental immunology

authors： Raynes JG,Eagling S,McAdam KP

更新日期：1991-03-01 00:00:00

abstract：:Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV ge...

journal_title：Clinical and experimental immunology

authors： Russi S,Dammacco F,Sansonno S,Pavone F,Sansonno D

更新日期：2015-12-01 00:00:00

abstract：:Clustering activity for neutrophil granulocytes was generated in pooled normal human serum (NHS) by incubation of the serum with preformed IgG aggregates, but not in heat-treated NHS (56 degrees C, 30 min), indicating that the function was complement-dependent. Judging from results of experiments with complement-defic...

journal_title：Clinical and experimental immunology

authors： Sturfelt G,Jonsson H,Hellmer G,Sjöholm AG

更新日期：1993-08-01 00:00:00

abstract：:Lymphocyte-enriched mononuclear cell fractions were obtained from the peripheral blood of four healthy young adults. Living B cells with membrane immunoglobulin (Ig) were studied by immunofluorescence to reveal exposed J-chain determinants or surface affinity for the secretory component (SC). Alcohol-fixed cell smears...

journal_title：Clinical and experimental immunology

authors： Brandtzaeg P

更新日期：1976-07-01 00:00:00

abstract：:Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

journal_title：Clinical and experimental immunology

authors： Löfdahl JM,Wahlström J,Sköld CM

更新日期：2006-09-01 00:00:00

abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

journal_title：Clinical and experimental immunology

authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

更新日期：1986-04-01 00:00:00

abstract：:Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-...

journal_title：Clinical and experimental immunology

authors： Faisant C,Boccon-Gibod I,Mansard C,Dumestre Perard C,Pralong P,Chatain C,Deroux A,Bouillet L

更新日期：2016-07-01 00:00:00

abstract：:Regulatory T cells (T(regs)) may inhibit immunity against cancer. Induction and expansion of T(regs) in the immunosuppressive microenvironment created by a growing tumour appear to be one of the mechanisms by which it can evade host defence. We studied the impact of CD25+ T(regs) in a B cell lymphoma model in which Ra...

journal_title：Clinical and experimental immunology

authors： Heier I,Hofgaard PO,Brandtzaeg P,Jahnsen FL,Karlsson M

更新日期：2008-05-01 00:00:00

abstract：:The present study reports a rare case of systemic M. scrofulaceum infection in an AIDS patient and analyses the inflammatory infiltrate in a lymph node by immunohistochemistry. Special emphasis is put on the histiocytes. The diffuse infiltrate consists mainly of large histiocytes that contain numerous bacilli. These c...

journal_title：Clinical and experimental immunology

authors： Delabie J,De Wolf-Peeters C,Bobbaers H,Bilbe G,Desmet VJ

更新日期：1991-08-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00