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Autoimmunity to endometrium and ovary in endometriosis.

Abstract：

:Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0.0001), ovary (3.58 +/- 0.87; P = 0.0092), theca cells (4.42 +/- 0.73; P less than 0.0001) and granulosa cells (3.33 +/- 0.63; P = 0.0024) were significantly higher in the patients' sera than in sera from 15 normal non-pregnant females. Antibody titres to granulosa cells were elevated (7.97 +/- 1.46; P = 0.0424) in their cervical secretions. Antibody titres to all tissues tested were similar in vaginal secretions of patients and controls. Immunofluorescent antibody assay of biopsied endometrial tissue and sera from the patients revealed the antibodies to be primarily IgG and IgA. The results suggest that autoantibodies to endometrium and ovary are present in patients with endometriosis.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Mathur S,Peress MR,Williamson HO,Youmans CD,Maney SA,Garvin AJ,Rust PF,Fudenberg HH

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

259-66

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

50

pub_type

杂志文章

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