A study of maternal lymphoid organs and the progeny following treatment with immunomodulating agents during pregnancy.

abstract：:T cells of C57BL/6J (B6) mice activated in vitro against the K and D determinants of the H-2d haplotype, and expanded in tissue culture in the presence of interleukin 2, were capable of rapidly killing lethally irradiated BALB/c recipients when injected intravenously. Mice given 10(6), 10(7) and 10(8) such T cells sur...

journal_title：Clinical and experimental immunology

authors： Andrus L,Atkinson K,Lafferty KJ

更新日期：1982-12-01 00:00:00

abstract：:The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was detected in eight out of 10 and the human BEG 2 Id in five out of 10 labial biopsies from patients with Sjögren's syndrome...

journal_title：Clinical and experimental immunology

authors： Watts RA,Ravirajan CT,Wilkinson LS,Williams W,Griffiths M,Butcher D,Horsfall AT,Staines NA,Isenberg DA

更新日期：1991-02-01 00:00:00

abstract：:Organ transplantation is the treatment of choice for patients with end-stage organ failure, but chronic immunosuppression is taking its toll in terms of morbidity and poor efficacy in preventing late graft loss. Therefore, a drug-free state would be desirable where the recipient permanently accepts a donor organ while...

journal_title：Clinical and experimental immunology

authors： Mahr B,Wekerle T

更新日期：2017-08-01 00:00:00

abstract：:In this study we demonstrate that IgG present in the sera of patients with primary Sjögren's syndrome (PSS) could bind and activate muscarinic acetylcholine receptors (mAChRs) of rat parotid gland. These antibodies were able to inhibit in a non-competitive manner the binding of 3H-quinuclidinyl benzilate (QNB) to mACh...

journal_title：Clinical and experimental immunology

authors： Bacman S,Sterin-Borda L,Camusso JJ,Arana R,Hubscher O,Borda E

更新日期：1996-06-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute febrile illness of early childhood, in which the activation of monocytes/macrophages plays a central role in the development of vasculitis during the acute stage of disease. In this study we investigated peripheral blood T cells of 10 patients with KD, focusing on the Th1 and Th2 imba...

journal_title：Clinical and experimental immunology

authors： Matsubara T,Katayama K,Matsuoka T,Fujiwara M,Koga M,Furukawa S

更新日期：1999-06-01 00:00:00

abstract：:The effect of anti-neutrophil cytoplasm autoantibodies (ANCA) on neutrophil activation was studied by pre-incubating neutrophils with IgG and F(ab')2 prepared from ANCA patients with Wegener's granulomatosis or microscopic polyarteritis. We measured the generation of inositol triphosphate (IP3) (a product of hydrolysi...

journal_title：Clinical and experimental immunology

authors： Lai KN,Lockwood CM

更新日期：1991-09-01 00:00:00

abstract：:Glucocorticoid hormones (GCH) regulate, through the apoptotic process, the negative selection of immature T cells in the thymus. Because apoptosis seems to occur also in the maintenance of peripheral tolerance, we have investigated whether GCH may induce apoptosis in human mature lymphocytes. Peripheral blood lymphocy...

journal_title：Clinical and experimental immunology

authors： Lanza L,Scudeletti M,Puppo F,Bosco O,Peirano L,Filaci G,Fecarotta E,Vidali G,Indiveri F

更新日期：1996-03-01 00:00:00

abstract：:Kawasaki disease (KD) is an immune-mediated vasculitis with symptoms that mimic febrile illness; the immune origin has been suggested but never proved. First, cell chip technology was used to screen immune targets cells. With the indirect immunofluorescence assay we found that the HeLa cell chip could be recognized by...

journal_title：Clinical and experimental immunology

authors： Cui J,Zhou Y,Hu H,Zhao L,Du Z,Du H

更新日期：2018-12-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been correlated to the occurrence of thromboembolic complications, thrombocytopenia, abortions and other disease manifestations. Sev...

journal_title：Clinical and experimental immunology

authors： Rubbert A,Bock E,Schwab J,Marienhagen J,Nüsslein H,Wolf F,Kalden JR

更新日期：1994-12-01 00:00:00

abstract：:It is well known that monocytes may play an active role in thrombogenesis, since they may express on their surface tissue factor, the major initiator of the clotting cascade. The results of this investigation demonstrate beta-2-glycoprotein I (beta2-GPI) mRNA expression by human peripheral blood monocytes, indicating ...

journal_title：Clinical and experimental immunology

authors： Conti F,Sorice M,Circella A,Alessandri C,Pittoni V,Caronti B,Calderaro C,Griggi T,Misasi R,Valesini G

更新日期：2003-06-01 00:00:00

abstract：:Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of...

journal_title：Clinical and experimental immunology

authors： Su W,Du L,Liu S,Deng J,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2018-07-01 00:00:00

abstract：:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (...

journal_title：Clinical and experimental immunology

authors： de Córdoba SR,de Jorge EG

更新日期：2008-01-01 00:00:00

abstract：:Earlier data suggest that gamma/delta T cells may play an important role in the immune response to Mycobacterium tuberculosis. The aim of this study was to determine the percentage of different gamma/delta subsets in peripheral blood of active tuberculosis patients with a positive or negative tuberculin reaction. Thir...

journal_title：Clinical and experimental immunology

authors： Szereday L,Baliko Z,Szekeres-Bartho J

更新日期：2003-02-01 00:00:00

abstract：:The expression and up-regulation of cell adhesion molecules on a human colonic epithelial cell line HT-29, and the peripheral blood T lymphocyte proliferation responses to bacterial superantigens presented by this cell line were investigated, compared with peripheral blood monocytes. In HT-29 cells, there was constitu...

journal_title：Clinical and experimental immunology

authors： Liu ZX,Sugawara S,Hiwatashi N,Noguchi M,Rikiishi H,Kumagai K,Toyota T

更新日期：1997-06-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:Although the role of the T cell-mediated autoimmune reaction in type 1 diabetes (T1D) is conclusive, studies including data from human circulating CD4(+) and CD8(+) lymphocytes subsets during the disease onset and posterior development are scarce. Further, chemokines and chemokine receptors are key players in the migr...

journal_title：Clinical and experimental immunology

authors： Hedman M,Faresjö M,Axelsson S,Ludvigsson J,Casas R

更新日期：2008-09-01 00:00:00

abstract：:In this study, we hypothesized that the granulomatous disorder sarcoidosis is not caused by a single pathogen, but rather results from abnormal responses of Toll-like receptors (TLRs) to conserved bacterial elements. Unsorted bronchoalveolar lavage (BAL) cells from patients with suspected pulmonary sarcoidosis and hea...

journal_title：Clinical and experimental immunology

authors： Gabrilovich MI,Walrath J,van Lunteren J,Nethery D,Seifu M,Kern JA,Harding CV,Tuscano L,Lee H,Williams SD,Mackay W,Tomashefski JF Jr,Silver RF

更新日期：2013-09-01 00:00:00

abstract：:In vitro studies have contributed substantially to the understanding of immunopathology of respiratory syncytial virus (RSV)-mediated disease. In the present study we compared the effect of RSV-infected dendritic cells on the time-course of the primary and memory/effector T cell response in vitro. Cultures with uninfe...

journal_title：Clinical and experimental immunology

authors： Rothoeft T,Fischer K,Zawatzki S,Schulz V,Schauer U,Körner Rettberg C

更新日期：2007-11-01 00:00:00

abstract：:The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

journal_title：Clinical and experimental immunology

authors： Rook GA

更新日期：1975-07-01 00:00:00

abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

journal_title：Clinical and experimental immunology

authors： Raynes JG,Eagling S,McAdam KP

更新日期：1991-03-01 00:00:00

abstract：:Allergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individ...

journal_title：Clinical and experimental immunology

authors： Pucci S,Incorvaia C

更新日期：2008-09-01 00:00:00

abstract：:A proportion of human monocytes form long needles of fibrin on their surfaces when they are briefly exposed to human plasma. A number of coagulation factor deficient plasmas (II, V, VII, VIII, von Willebrand, IX, X, XI and XII) were tested for their ability to promote formation of this fibrin. Monocytes failed to make...

journal_title：Clinical and experimental immunology

authors： Hogg N

更新日期：1983-09-01 00:00:00

abstract：:During 25 years of research since HIV-1 was first identified in Paris, there have been great advances in our understanding of the virus and of the immune system. Practical advances include the early development of diagnostic tests of infection that made blood donation safe, and since 1996, combination anti-retroviral ...

journal_title：Clinical and experimental immunology

authors： Weiss RA

更新日期：2008-05-01 00:00:00

abstract：:2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be mediated partly through its potent toxicity tow...

journal_title：Clinical and experimental immunology

authors： Singh V,Prajeeth CK,Gudi V,Bénardais K,Voss EV,Stangel M

更新日期：2013-08-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00

abstract：:Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

journal_title：Clinical and experimental immunology

authors： Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

更新日期：1997-02-01 00:00:00

abstract：:To investigate the role of seminal plasma in human B cell functions, its effect on the proliferation and antibody secretion of tonsillar B cells and an Epstein-Barr virus (EBV) transformed human B cell line, A4, was examined. Seminal plasma inhibited both the proliferation and differentiation of normal B cells only wh...

journal_title：Clinical and experimental immunology

authors： Lee HK,Lee HH,Park YM,Lee JH,Ha TY

更新日期：1991-07-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement o...

journal_title：Clinical and experimental immunology

authors： Bartlomiejczyk MA,Swierzko AS,Brzostek A,Dziadek J,Cedzynski M

更新日期：2014-11-01 00:00:00