Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.

Abstract:

:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (CFH) with atypical haemolytic uraemic syndrome (aHUS), age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis (MPGN). This review summarizes our current knowledge of CFH genetics and examines the CFH genotype-phenotype correlations that are helping to understand the molecular basis underlying these renal and ocular pathologies.

journal_name

Clin Exp Immunol

authors

de Córdoba SR,de Jorge EG

doi

10.1111/j.1365-2249.2007.03552.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1-13

issue

1

eissn

0009-9104

issn

1365-2249

pii

CEI3552

journal_volume

151

pub_type

杂志文章,评审
  • The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.

    abstract::The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Rook GA

    更新日期:1975-07-01 00:00:00

  • Protein A-like activity and streptococcal cross-reactions.

    abstract::Recognition of the protein A-like activity of some strains of group A streptococci has thrown doubt on much previous work suggesting antigenic cross-reactions between these streptococci and mammalian tissues. The strains used in our previous studies have now been examined by the mixed reverse passive antiglobulin reac...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kingston D

    更新日期:1981-10-01 00:00:00

  • Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS).

    abstract::The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen respo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

    更新日期:1984-04-01 00:00:00

  • HBsAg in urine: a new approach for the detection of urinary antigens.

    abstract::In order to define the optimal conditions for detection of microbial antigens in urine, urinary HBsAg excreted during hepatitis B was chosen as a model. Using commercial kits, which mainly involve anti-discontinuous epitopes, we found urinary HBsAg in only 50% of patients with HBsAg in their sera. In contrast, with an...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb02991.x

    authors: Badur S,Grangeot-Keros L,Pillot J

    更新日期:1992-02-01 00:00:00

  • Effect of IgG for intravenous use on Fc receptor-mediated phagocytosis by human monocytes.

    abstract::Polyspecific IgG given intravenously at high doses (IVIG) is used for immunomodulatory therapy in autoimmune diseases such as idiopathic thrombocytopenic purpura and myasthenia gravis. It is assumed that the clinical effect is brought about in part by a modulation of mononuclear phagocyte function, in particular by an...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb05421.x

    authors: Jungi TW,Brcic M,Kuhnert P,Spycher MO,Li F,Nydegger UE

    更新日期:1990-10-01 00:00:00

  • Immunization against Plasmodium falciparum asexual blood stages using soluble antigens.

    abstract::Saimiri sciureus monkeys have been successfully immunized against a human malaria parasite, Plasmodium falciparum, using soluble antigens purified from schizont and merozoite extracts. High levels of antibodies reacting with schizont and merozoite specific polypeptides of 140 and 200 kdaltons were detected in the sera...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Perrin LH,Loche M,Dedet JP,Roussilhon C,Fandeur T

    更新日期:1984-04-01 00:00:00

  • Importance of stromal determinants in the generation of dendritic and natural killer cells in the human spleen.

    abstract::Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02792.x

    authors: Briard D,Azzarone B,Brouty-Boyé D

    更新日期:2005-05-01 00:00:00

  • Suppression of delayed hypersensitivity skin reactions to tuberculin by M. leprae antigens in patients with lepromatous and tuberculoid leprosy.

    abstract::Delayed hypersensitivity skin reactions to tuberculin when injected alone or in mixture with antigens of M. leprae were examined in leprosy patients and in healthy controls. The tuberculin reaction was significantly inhibited in more than one half of both LL and BT patients by the soluble extract of M. leprae (leprosi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Sengupta U,Sinha S,Ramu G,Lamb J,Ivanyi J

    更新日期:1987-04-01 00:00:00

  • Pathogen infections and primary biliary cholangitis.

    abstract::Primary biliary cholangitis (PBC) is a multi-factorial disease caused by the interaction of both genetic predisposition and environmental triggers. Bacterial infection has been investigated most intensively, both epidemiologically and experimentally, as a prime environmental aetiology in PBC. The association of recurr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/cei.13198

    authors: Tanaka A,Leung PSC,Gershwin ME

    更新日期:2019-01-01 00:00:00

  • Human TSLP directly enhances expansion of CD8+ T cells.

    abstract::Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03731.x

    authors: Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

    更新日期:2008-10-01 00:00:00

  • Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults.

    abstract::Although pituitary hormones are known to affect immune function, treated hypopituitarism is not a recognized cause of immune deficiency in humans. We set out to assess integrity of baseline and stimulated immune function in severely hypopituitary adults. Twenty-one panhypopituitary adults (group 1), on stable pituitar...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2009.03881.x

    authors: Mukherjee A,Helbert M,Ryder WD,Borrow R,Davis JR,Shalet SM

    更新日期:2009-05-01 00:00:00

  • Monoclonal anti-poly(rA) hybridoma antibodies from an autoimmune MRL/MpJ-lpr/lpr mouse.

    abstract::Three B cell hybridomas were produced by the fusion of spleen cells from a 5 month old MRL/Mp-lpr/lpr mouse with the myeloma cell line, NS-1. By competitive inhibition, all three monoclonal antibodies (MoAb) were specific for poly(rA) and were inhibited to a lesser extent by dDNA, nDNA, poly(rI) and poly(rC). Moreover...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dang H,Fischbach M,Erdos M,Talal N

    更新日期:1985-07-01 00:00:00

  • Interferons and interferon (IFN)-inducible protein 10 during highly active anti-retroviral therapy (HAART)-possible immunosuppressive role of IFN-alpha in HIV infection.

    abstract::Interferons play an important, but incompletely understood role in HIV-related disease. We investigated the effect of HAART on plasma levels of IFN-alpha, IFN-gamma, neopterin and interferon-inducible protein 10 (IP-10) in 41 HIV-infected patients during 78 weeks of therapy. At baseline HIV-infected patients had raise...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01144.x

    authors: Stylianou E,Aukrust P,Bendtzen K,Müller F,Frøland SS

    更新日期:2000-03-01 00:00:00

  • GPLA antigens are not expressed on guinea-pig epididymal spermatozoa.

    abstract::The expression of guinea-pig major histocompatibility antigens (class I and II) has been investigated on guinea-pig epididymal spermatozoa. Specific alloantisera (anti-B1, anti-B3, anti-Ia2,4 and anti-Ia1,3,7) were obtained by cross-immunization of strains 2, 13 and BIO-AD animals with relevant spleen cell membranes. ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Thyphronitis G,De Almeida M,Neveu T,Voisin GA

    更新日期:1984-09-01 00:00:00

  • Enhanced therapeutic effect of B cell-depleting anti-CD20 antibodies upon combination with in-situ dendritic cell vaccination in advanced lymphoma.

    abstract::The present standard of care for B cell non-Hodgkin's lymphoma includes the anti-CD20 monoclonal antibody rituximab. Although combination treatments with chemotherapy and rituximab improved the duration of remissions and overall survival in indolent B cell lymphoma, the disease is essentially incurable. Thus, new ther...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2012.04658.x

    authors: Manzur S,Cohen S,Haimovich J,Hollander N

    更新日期:2012-12-01 00:00:00

  • Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis.

    abstract::Secretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specific for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN), 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membrano...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb07947.x

    authors: Rostoker G,Terzidis H,Petit-Phar M,Meillet D,Lang P,Dubert JM,Lagrue G,Weil B

    更新日期:1992-11-01 00:00:00

  • Increased CD11b expression on polymorphonuclear leucocytes and cytokine profiles in patients with Kawasaki disease.

    abstract::Clinical evidence implicates polymorphonuclear leucocytes in the pathogenesis of vasculitis in Kawasaki disease. We examined modulation of expression of adhesion molecules (CD11b and CD62L) on polymorphonuclear leucocytes and how this expression is related to serum cytokine concentrations. In 18 patients with Kawasaki...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03326.x

    authors: Kobayashi T,Kimura H,Okada Y,Inoue Y,Kobayashi T,Shinohara M,Morikawa A

    更新日期:2007-04-01 00:00:00

  • Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis.

    abstract::Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01779.x

    authors: Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

    更新日期:2002-03-01 00:00:00

  • Experimental autoimmune uveoretinitis (EAU) versus experimental allergic encephalomyelitis (EAE): a comparison of T cell-mediated mechanisms.

    abstract::EAU is a model of ocular inflammatory disease. EAU resembles another T cell-mediated autoimmune disease--experimental allergic encephalomyelitis--since both have increased expression of MHC class II molecules in the target tissue, can be adoptively transferred by activated CD4+ T cells and are inhibited by cyclosporin...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.1992.tb06926.x

    authors: Calder VL,Lightman SL

    更新日期:1992-08-01 00:00:00

  • Reduction of human anti-tetanus toxoid antibody in hu-PBL-SCID mice by immunodominant peptides of tetanus toxoid.

    abstract::Immunotherapy of murine autoimmune and allergic diseases by administration of peptides corresponding to the dominant T cell epitope is a reality. However, problems remain in applying this therapy to reduce antibody responses in humans. To overcome these difficulties, a preclinical system was developed to test the effe...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02521.x

    authors: Jackson DJ,Elson CJ,Kumpel BM

    更新日期:2004-08-01 00:00:00

  • GM-CSF and IL-12 production by malignant plasma cells promotes cell-mediated immune responses against monoclonal Ig determinants in a light chain myeloma model.

    abstract::Immune responses towards malignant plasma cells have clearly been demonstrated in the course of monoclonal B cell dyscrasias and shown to be mostly specific for idiotypic determinants of the monoclonal immunoglobulin (Ig). These responses are specifically efficient against lymphoma cells expressing a membrane form of ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01929.x

    authors: Galea HR,Cogné M

    更新日期:2002-08-01 00:00:00

  • Identification of mouse T and B lymphocytes from cytocentrifuged cell smears.

    abstract::A method enabling direct enumeration of mouse T and B cells from cytocentrifuged cell smears is described. The acid alpha-naphthyl acetate esterase (ANAE) staining was used as marker for T cells. The distribution of the ANAE marker-carrying lymphocytes closely followed the percentual distribution of T cells in spleen ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Ranki A,Tötterman TH,Häyry P

    更新日期:1976-12-01 00:00:00

  • Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration.

    abstract::Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Greenspan JS,Gadol N,Olson JA,Talal N

    更新日期:1981-06-01 00:00:00

  • Generation and functional analysis of T cell lines and clones specific for schistosomula released products (SRP-A).

    abstract::Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

    更新日期:1987-08-01 00:00:00

  • Inflammation and immune resolution.

    abstract::Inspired by the advances presented at the Inflammation and Immune Resolution Plenary Session at the British Society for Immunology Congress, December 2017, in this issue of Clinical & Experimental Immunology we present a Review Series on Inflammation and Immune Resolution. Our selection ranges from an overview of curr...

    journal_title:Clinical and experimental immunology

    pub_type: 社论

    doi:10.1111/cei.13155

    authors: Taams LS

    更新日期:2018-07-01 00:00:00

  • Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality.

    abstract::The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patien...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12181

    authors: Frostegård AG,Hua X,Su J,Carrero JJ,Heimbürger O,Bárány P,Stenvinkel P,Frostegård J

    更新日期:2013-12-01 00:00:00

  • A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.

    abstract::Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13262

    authors: Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

    更新日期:2019-05-01 00:00:00

  • Increased expression of class II antigens of the major histocompatibility complex on alveolar macrophages and alveolar type II cells and interleukin-1 (IL-1) secretion from alveolar macrophages in an animal model of silicosis.

    abstract::Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

    更新日期:1989-08-01 00:00:00

  • A study of maternal lymphoid organs and the progeny following treatment with immunomodulating agents during pregnancy.

    abstract::Whether differences in foetoplacental weight and post-implantation mortality in rodents are secondary to heterosis and inbreeding depression or antigenic differences between mother and foetus has been a continuing controversy. To determine whether non-specific depression or stimulation of the maternal immune system af...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Scott JR,Feldbush TL,Covault JM

    更新日期:1977-12-01 00:00:00

  • Eosinophil involvement in rheumatoid arthritis as reflected by elevated serum levels of eosinophil cationic protein.

    abstract::Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the time of the investigation the patients were without drug treatment. They had normal blood counts of eosinophils but on ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hällgren R,Feltelius N,Svenson K,Venge P

    更新日期:1985-03-01 00:00:00