Abstract:
:Kawasaki disease (KD) is an acute febrile illness of early childhood, in which the activation of monocytes/macrophages plays a central role in the development of vasculitis during the acute stage of disease. In this study we investigated peripheral blood T cells of 10 patients with KD, focusing on the Th1 and Th2 imbalance, using intracellular cytokine staining and analysis of the cytokine-producing T cells by flow cytometry. We observed a decrease in the numbers of IFN-gamma-producing, but not IL-4-producing, CD3+ T cells, during the acute stage. Our results suggest that there is an imbalance of Th1 and Th2 subsets during the acute stage of KD.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Matsubara T,Katayama K,Matsuoka T,Fujiwara M,Koga M,Furukawa Sdoi
10.1046/j.1365-2249.1999.00899.xsubject
Has Abstractpub_date
1999-06-01 00:00:00pages
554-7issue
3eissn
0009-9104issn
1365-2249journal_volume
116pub_type
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