Antigenic stimulation during ultraviolet therapy in man does not result in immunological tolerance.

abstract：:Recent studies have suggested that a high percentage of Epstein-Barr virus (EBV)-infected lymphocytes in peripheral blood of patients with chronic, active EBV infection (CAEBV) is of T cell origin. Although T cells are expanded oligoclonally in CAEBV, it is not clear whether the restricted diversity of T cells arise f...

journal_title：Clinical and experimental immunology

authors： Toyabe S,Harada W,Uchiyama M

更新日期：2003-10-01 00:00:00

abstract：:Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

journal_title：Clinical and experimental immunology

authors： Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

更新日期：2007-08-01 00:00:00

abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

journal_title：Clinical and experimental immunology

authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

更新日期：2007-10-01 00:00:00

abstract：:Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of inflammation in ...

journal_title：Clinical and experimental immunology

authors： Obermeier F,Dunger N,Strauch UG,Grunwald N,Herfarth H,Schölmerich J,Falk W

更新日期：2003-11-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:The level and avidity of anti-DNA antibody in the serum of New Zealand Black/White (NZB/W F1) hybrid mice has been determined. The results show that there is an age and sex-related variation in the avidity of this antibody. In mice of both sexes, the avidity of circulating anti-DNA antibody increases up to 5 months of...

journal_title：Clinical and experimental immunology

authors： Steward MW,Katz FE,West NJ

更新日期：1975-07-01 00:00:00

abstract：:Myeloid FcαRI, a receptor for immunoglobulin (Ig)A, mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent. Anti-inflammatory signalling is triggered by monomeric targeting using anti-FcαRI Fab or IgA ligand binding, which inhibits immune and n...

journal_title：Clinical and experimental immunology

authors： Watanabe T,Kanamaru Y,Liu C,Suzuki Y,Tada N,Okumura K,Horikoshi S,Tomino Y

更新日期：2011-11-01 00:00:00

abstract：:The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of he...

journal_title：Clinical and experimental immunology

authors： Ferrer JM,Iglesias J,Hernández M,Matamoros N

更新日期：1995-11-01 00:00:00

abstract：:Increasing evidence has demonstrated that the immune system closely interacts with other physiological systems, whose communications are mediated by circulating cytokines and hormones. The aim of our study was to test whether the number and cytolytic activity of NK cells in a group of relatively healthy Italian nonage...

journal_title：Clinical and experimental immunology

authors： Mariani E,Ravaglia G,Forti P,Meneghetti A,Tarozzi A,Maioli F,Boschi F,Pratelli L,Pizzoferrato A,Piras F,Facchini A

更新日期：1999-04-01 00:00:00

abstract：:A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...

journal_title：Clinical and experimental immunology

authors： Zalewski PD,Forbes IJ

更新日期：1979-06-01 00:00:00

abstract：:The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumour necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of them presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated con...

journal_title：Clinical and experimental immunology

authors： Sarno EN,Grau GE,Vieira LM,Nery JA

更新日期：1991-04-01 00:00:00

abstract：:Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

journal_title：Clinical and experimental immunology

authors： Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

更新日期：1984-01-01 00:00:00

abstract：:HLA class II-restricted proliferative and cytotoxic T cell (CTL) responses to B cell chronic lymphocytic leukaemia (B-CLL) can be generated using autologous dendritic cells (DCs) pulsed with tumour cell lysate. In this study a number of different approaches were used to optimize further the in vitro system. First, the...

journal_title：Clinical and experimental immunology

authors： Goddard RV,Prentice AG,Copplestone JA,Kaminski ER

更新日期：2003-01-01 00:00:00

abstract：:The cytotoxic responses of peripheral blood lymphocytes from cottontop tamarins to in vitro restimulation with autologous lymphoblastoid cell lines (LCL) were assayed. Lymphocytes from immune tamarins that had recovered from EBV challenge developed potent cytotoxicity for natural killer (NK) cell targets and for autol...

journal_title：Clinical and experimental immunology

authors： Wilson AD,Shooshstari M,Finerty S,Watkins P,Morgan AJ

更新日期：1996-02-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:IL-10 and IL-12 are cytokines which are important in regulating immune responses. Plasma levels of IL-10 and autoantibodies against double-stranded DNA (dsDNA) often mirror disease activity in patients with SLE. IL-12 secretion from SLE patients' blood mononuclear cells also correlates with disease activity, but has a...

journal_title：Clinical and experimental immunology

authors： Tyrrell-Price J,Lydyard PM,Isenberg DA

更新日期：2001-04-01 00:00:00

abstract：:Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

journal_title：Clinical and experimental immunology

authors： Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

更新日期：2009-05-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of PR3-ANCA do not always correspond to clinical disease activity. To investigate the relationship between functional effects of...

journal_title：Clinical and experimental immunology

authors： van der Geld YM,Tool AT,Videler J,de Haas M,Tervaert JW,Stegeman CA,Limburg PC,Kallenberg CG,Roos D

更新日期：2002-09-01 00:00:00

abstract：:Immune complexes (IC) in sera and synovial fluid (SF) from patients with juvenile (rheumatoid) arthritis (JA) were isolated by making use of polyethylene glycol (PEG) to precipitate IC and then using staphylococcal protein A to separate the IC. The isolated IC were compared to IC in sera analysed by sucrose density gr...

journal_title：Clinical and experimental immunology

authors： Moore TL,Dorner RW,Sheridan PW,Zuckner J

更新日期：1984-05-01 00:00:00

abstract：:IgE was isolated from a patient with the hyper IgE, recurrent infection syndrome by immunoadsorption on sepharose bound goat anti-human IgE. Addition of this IgE to a monolayer culture of human monocytes resulted in a dose-dependent increase in PGE2 secretion. The addition of F(ab')2 fraction of goat anti-human IgE in...

journal_title：Clinical and experimental immunology

authors： Passwell JH,Geiger B,Levanon M,Davidsohn J,Cohen BE,Ramot B

更新日期：1984-12-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:Cyclosporin A (Cy A) enhances immunoglobulin (Ig) production by EB virus stimulated peripheral blood lymphocytes from normal subjects with prior immunity to EB virus. In 11 normal adults, this enhancement of Ig production correlated with T cell-mediated cytotoxic regression. Cultures from normal healthy adults without...

journal_title：Clinical and experimental immunology

authors： Pereira RS,Gear AJ,Doré CJ,Webster AD

更新日期：1983-07-01 00:00:00

abstract：:The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats wit...

journal_title：Clinical and experimental immunology

authors： Seno K,Yasunaga M,Kajiya H,Izaki-Hagio K,Morita H,Yoneda M,Hirofuji T,Ohno J

更新日期：2017-12-01 00:00:00

abstract：:The functional integrity of the local immune system in vitamin A-deficient (A-) rats was investigated. Secretory IgA levels in the intestinal fluid of A- rats were significantly lower than in controls. This and the decrease in intensity of immunofluorescent staining for secretory component (SC) in the intestinal cells...

journal_title：Clinical and experimental immunology

authors： Sirisinha S,Darip MD,Moongkarndi P,Ongsakul M,Lamb AJ

更新日期：1980-04-01 00:00:00

abstract：:Children receiving anti-leukaemic therapy often become susceptible to severe herpesvirus infection. To investigate specific immunity to herpes simplex virus (HSV) in patients with acute lymphoblastic leukaemia (ALL), in first remission and receiving maintenance chemotherapy, we measured their HSV specific T responder ...

journal_title：Clinical and experimental immunology

authors： Tellez PA,Odom L,Hayward AR

更新日期：1985-12-01 00:00:00

abstract：:Delayed hypersensitivity skin reactions to tuberculin when injected alone or in mixture with antigens of M. leprae were examined in leprosy patients and in healthy controls. The tuberculin reaction was significantly inhibited in more than one half of both LL and BT patients by the soluble extract of M. leprae (leprosi...

journal_title：Clinical and experimental immunology

authors： Sengupta U,Sinha S,Ramu G,Lamb J,Ivanyi J

更新日期：1987-04-01 00:00:00

abstract：:Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are common diseases dependent on environmental factors that activate the immune system in unknown ways. Mannan is a group of polysaccharides common in the environment; they are potentially pathogenic, because at least some of them induce Ps-, PsA-...

journal_title：Clinical and experimental immunology

authors： Hagert C,Siitonen R,Li XG,Liljenbäck H,Roivainen A,Holmdahl R

更新日期：2019-06-01 00:00:00

abstract：:The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now me...

journal_title：Clinical and experimental immunology

authors： Atkinson AP,Cedzynski M,Szemraj J,St Swierzko A,Bak-Romaniszyn L,Banasik M,Zeman K,Matsushita M,Turner ML,Kilpatrick DC

更新日期：2004-12-01 00:00:00

abstract：:Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. T...

journal_title：Clinical and experimental immunology

authors： Götz M,Zielinski CC,Ahmad R,Eibl M

更新日期：1982-10-01 00:00:00