Abstract:
:Recent studies have suggested that a high percentage of Epstein-Barr virus (EBV)-infected lymphocytes in peripheral blood of patients with chronic, active EBV infection (CAEBV) is of T cell origin. Although T cells are expanded oligoclonally in CAEBV, it is not clear whether the restricted diversity of T cells arise from immune reaction against EBV-related antigens or from proliferation of EBV-infected cells. We experienced a patient with CAEBV who had biclonal expansion of peripheral blood T cells. We identified clonotypes of these two T cell clones in detail and purified the T cell clones. EBV infected mainly the two T cell clones, whereas the viral loads in peripheral blood cells other than these T cell clones were low or undetectable. The EBV strains infecting the two T cells clones were indistinguishable from each other by a series of genotype analyses of the virus. These results suggest that the two T cell clones infected with the same monoclonal EBV proliferated in peripheral blood of the patient.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Toyabe S,Harada W,Uchiyama Mdoi
10.1046/j.1365-2249.2003.02270.xsubject
Has Abstractpub_date
2003-10-01 00:00:00pages
92-7issue
1eissn
0009-9104issn
1365-2249pii
2270journal_volume
134pub_type
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