Beta-2-glycoprotein I expression on monocytes is increased in anti-phospholipid antibody syndrome and correlates with tissue factor expression.

Abstract:

:It is well known that monocytes may play an active role in thrombogenesis, since they may express on their surface tissue factor, the major initiator of the clotting cascade. The results of this investigation demonstrate beta-2-glycoprotein I (beta2-GPI) mRNA expression by human peripheral blood monocytes, indicating that these cells synthesize beta2-GPI. In addition, we show beta2-GPI expression on cell surface of these cells by flow cytometric analysis, and the presence of this protein in cell lysate by Western blot. Interestingly, beta2-GPI expression on monocytes is significantly increased in patients with anti-phospholipid syndrome (APS) or systemic lupus erythematosus (SLE) as against healthy blood donors and correlates with tissue factor expression on monocytes. These findings support the view that monocytes are able to synthesize beta2-GPI and suggest that patients with APS may have increased beta2-GPI exposure on cell surface, which leads to persistently high monocyte tissue factor expression and consequently to a prothrombotic diathesis.

journal_name

Clin Exp Immunol

authors

Conti F,Sorice M,Circella A,Alessandri C,Pittoni V,Caronti B,Calderaro C,Griggi T,Misasi R,Valesini G

doi

10.1046/j.1365-2249.2003.02180.x

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

509-16

issue

3

eissn

0009-9104

issn

1365-2249

pii

2180

journal_volume

132

pub_type

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