Immune response modulation by recombinant peptides expressed in virus-like particles.

abstract：:Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

journal_title：Clinical and experimental immunology

authors： Kudoh A,Sakai T,Ishihara H,Matsuki A

更新日期：2001-07-01 00:00:00

abstract：:Suppression of the lymphocyte response to concanavalin A (Con A), phytohaemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in twenty-four patients with recently active-recovering multiple sclerosis (MS), twelve with inactive MS and twenty-three healthy con...

journal_title：Clinical and experimental immunology

authors： Gonzalez RL,Dau PC,Spitler LE

更新日期：1979-04-01 00:00:00

abstract：:Antibody reactivity against the 'mitochondrial M2 antigen' was determined in sera from 10 patients with primary biliary cirrhosis (PBC), using Western blotting after SDS-PAGE separation of rat liver mitochondria (RLM) and plasma membrane proteins. The molecular weights of the major M2 antigens in rat liver mitochondri...

journal_title：Clinical and experimental immunology

authors： Sundin U,Sundqvist KG

更新日期：1991-03-01 00:00:00

abstract：:The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanis...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Parroni R,D'alò S,Pistoia MA,Doglioni C,Cifone MG,Corazza GR

更新日期：2000-05-01 00:00:00

abstract：:To gain some insight into the pathogenesis of proliferative lupus nephritis in MRL/lpr mice we investigated the kinetics of removal of immune complexes from the circulation, the carrier state of blood cells, the uptake of complexes by the mononuclear phagocyte system, and the localization of complexes in kidneys. In n...

journal_title：Clinical and experimental immunology

authors： Granholm NA,Cavallo T

更新日期：1990-11-01 00:00:00

abstract：:Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...

journal_title：Clinical and experimental immunology

authors： Sitohy B,Hammarström S,Danielsson A,Hammarström ML

更新日期：2008-02-01 00:00:00

abstract：:A technique is described which shows how to obtain a suspension of only progressively motile spermatozoa, from semen, by active penetration into an overlying buffer layer. About 60% of the number of motile spermatozoa in the original semen sample can be obtained as an output in the removed buffer layer. With this meth...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Rümke P

更新日期：1978-01-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG), developed a century ago, is the only licensed tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies with no apparent protection in some population, and mechanisms of its immune protection is poorly known, and yet BCG is the most widely used vaccine, w...

journal_title：Clinical and experimental immunology

authors： Abebe F

更新日期：2012-09-01 00:00:00

abstract：:GVHD is a major complication in allogeneic bone marrow transplantation (BMT). MHC class I mismatching increases GVHD, but in MHC-matched BMT minor histocompatibility antigens (mH) presented by MHC class I result in significant GVHD. To examine the modification of GVHD in the absence of cell surface MHC class I molecul...

journal_title：Clinical and experimental immunology

authors： Shenoy S,Desch K,Duffy B,Thorson P,Mohanakumar T

更新日期：1998-05-01 00:00:00

abstract：:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immun...

journal_title：Clinical and experimental immunology

authors： Kinane DF,Lappin DF,Koulouri O,Buckley A

更新日期：1999-03-01 00:00:00

abstract：:The effect of normal human peripheral blood polymorphonuclear leucocytes on in vitro multiplication of Plasmodium falciparum malaria parasites was investigated. It was shown that normal neutrophils were able to phagocytose parasitized erythrocytes and free parasites and thus inhibit in vitro multiplication of the para...

journal_title：Clinical and experimental immunology

authors： Kharazmi A,Jepsen S

更新日期：1984-08-01 00:00:00

abstract：:A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of ...

journal_title：Clinical and experimental immunology

authors： Cameron SA,White SM,Arrollo D,Shulman ST,Rowley AH

更新日期：2017-11-01 00:00:00

abstract：:Anti-citrullinated peptide antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). However, the predominant B cell epitopes have not yet been defined. The aim of this study was to examine the reactivity of ACPA against different peptides derived from citrullinated proteins and to investigate whether or no...

journal_title：Clinical and experimental immunology

authors： Goules JD,Goules AV,Tzioufas AG

更新日期：2013-10-01 00:00:00

abstract：:It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL...

journal_title：Clinical and experimental immunology

authors： Pardi R,Zocchi MR,Ferrero E,Ciboddo GF,Inverardi L,Rugarli C

更新日期：1984-09-01 00:00:00

abstract：:Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. T...

journal_title：Clinical and experimental immunology

authors： Götz M,Zielinski CC,Ahmad R,Eibl M

更新日期：1982-10-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00

abstract：:Antibodies to extractable nuclear antigens (ENA) were analysed in the sera of fifty-two patients with severe rheumatoid arthritis (RA) who were divided into two categories: twenty-five with arthritis only and twenty-seven with extra-articular disease. Using haemagglutination, counterimmunoelectropheresis (CIE) and dou...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Erhardt CC,Maini RN

更新日期：1980-01-01 00:00:00

abstract：:In vitro lymphocyte function of 13 patients with selective IgA deficiency was studied. IgG, IgA and IgM secretion by pokeweed mitogen-stimulated peripheral blood lymphocytes from normal donors and IgA deficient patients was measured by an enzyme-linked immunosorbent assay. Addition of concanavalin A or hydrocortisone ...

journal_title：Clinical and experimental immunology

authors： De la Concha EG,Subiza JL,Fontán G,Pascual-Salcedo D,Sequí J,Bootello A

更新日期：1982-08-01 00:00:00

abstract：:The family of Toll-like receptors (TLRs) initiates innate immune responses, and Toll-like receptor 4 (TLR4) was considered to be an important player in the initiation and progression of atherosclerotic disease. The aim of the study was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs)...

journal_title：Clinical and experimental immunology

authors： Geng HL,Lu HQ,Zhang LZ,Zhang H,Zhou L,Wang H,Zhong RQ

更新日期：2006-02-01 00:00:00

abstract：:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations t...

journal_title：Clinical and experimental immunology

authors： Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

更新日期：2001-06-01 00:00:00

abstract：:To characterize the antigenic parts of the 16K protein of Mycobacterium tuberculosis, overlapping peptides according to the amino acid sequence of the 16K protein were synthesized. In total, 14 peptides of 20 amino acids in length with an overlap of 10 amino acids and two additional decapeptides (amino acids 31-40 and...

journal_title：Clinical and experimental immunology

authors： Verbon A,Hartskeerl RA,Moreno C,Kolk AH

更新日期：1992-09-01 00:00:00

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

journal_title：Clinical and experimental immunology

authors： Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

更新日期：1994-03-01 00:00:00

abstract：:Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying the development of inflammatory bowel disease. However, this model cannot be used when therapeutics designed to address human targets do not interact with the respective...

journal_title：Clinical and experimental immunology

authors： Nolte T,Zadeh-Khorasani M,Safarov O,Rueff F,Gülberg V,Herbach N,Wollenberg A,Mueller T,Siebeck M,Wolf E,Gropp R

更新日期：2013-05-01 00:00:00

abstract：:Allergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individ...

journal_title：Clinical and experimental immunology

authors： Pucci S,Incorvaia C

更新日期：2008-09-01 00:00:00

abstract：:Polyspecific IgG given intravenously at high doses (IVIG) is used for immunomodulatory therapy in autoimmune diseases such as idiopathic thrombocytopenic purpura and myasthenia gravis. It is assumed that the clinical effect is brought about in part by a modulation of mononuclear phagocyte function, in particular by an...

journal_title：Clinical and experimental immunology

authors： Jungi TW,Brcic M,Kuhnert P,Spycher MO,Li F,Nydegger UE

更新日期：1990-10-01 00:00:00

abstract：:When MRL/lpr (H-2k) spleen cells were intraperitoneally injected into C.B-17-scid/scid (severe combined immunodeficient (SCID)) (H-2d) mice, the SCID (SCID-MRL/lpr) mice manifested a severe wasting syndrome with weight loss, splenic atrophy, and lymphoid cell infiltration in the liver and lung, as seen in lpr-GVHD. In...

journal_title：Clinical and experimental immunology

authors： Hosaka N,Nagata N,Miyashima S,Ikehara S

更新日期：1994-06-01 00:00:00

abstract：:Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and i...

journal_title：Clinical and experimental immunology

authors： Blom AM,Volokhina EB,Fransson V,Strömberg P,Berghard L,Viktorelius M,Mollnes TE,López-Trascasa M,van den Heuvel LP,Goodship TH,Marchbank KJ,Okroj M

更新日期：2014-10-01 00:00:00

abstract：:The modulatory effect of human milk proteins from colostrum and late milk on the proliferative response of human T lymphocytes activated by mitogens (OKT3 and leucoagglutinin from Phaseolus vulgaris) and alloantigens was studied. High concentrations (10-100 micrograms/ml) of crude colostral milk proteins had an inhibi...

journal_title：Clinical and experimental immunology

authors： Mincheva-Nilsson L,Hammarström ML,Juto P,Hammarström S

更新日期：1990-03-01 00:00:00