Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease.

abstract：:IL-10 and IL-12 are cytokines which are important in regulating immune responses. Plasma levels of IL-10 and autoantibodies against double-stranded DNA (dsDNA) often mirror disease activity in patients with SLE. IL-12 secretion from SLE patients' blood mononuclear cells also correlates with disease activity, but has a...

journal_title：Clinical and experimental immunology

authors： Tyrrell-Price J,Lydyard PM,Isenberg DA

更新日期：2001-04-01 00:00:00

abstract：:Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patient...

journal_title：Clinical and experimental immunology

authors： Pickford WJ,Gudi V,Haggart AM,Lewis BJ,Herriot R,Barker RN,Ormerod AD

更新日期：2015-05-01 00:00:00

abstract：:Serum from 98 Thai adults infected with Plasmodium falciparum were examined for the presence of autoantibodies. Malarial containing antibodies sera were also revealed positive for anti-nuclear antibodies with fluorescence speckled pattern, anti-smooth muscle antibodies, anti-mitochondria antibodies and rheumatoid fact...

journal_title：Clinical and experimental immunology

authors： Boonpucknavig S,Ekapanyakul G

更新日期：1984-10-01 00:00:00

abstract：:The effect of anti-immunoglobulin (anti-Ig) on cultures of established human B-cell lines was studied to develop models for the initiation and regulation of immune responses. DNA synthesis in one line, BM, measured by [125I]iododeoxyuridine (IUdR) incorporation, was stimulated by anti-Ig when the continuously prolifer...

journal_title：Clinical and experimental immunology

authors： Kishimoto T,Ralph P,Good RA

更新日期：1977-10-01 00:00:00

abstract：:Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. T...

journal_title：Clinical and experimental immunology

authors： Götz M,Zielinski CC,Ahmad R,Eibl M

更新日期：1982-10-01 00:00:00

abstract：:EAU is a model of ocular inflammatory disease. EAU resembles another T cell-mediated autoimmune disease--experimental allergic encephalomyelitis--since both have increased expression of MHC class II molecules in the target tissue, can be adoptively transferred by activated CD4+ T cells and are inhibited by cyclosporin...

journal_title：Clinical and experimental immunology

authors： Calder VL,Lightman SL

更新日期：1992-08-01 00:00:00

abstract：:In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into...

journal_title：Clinical and experimental immunology

authors： Luan ZG,Zhang J,Yin XH,Ma XC,Guo RX

更新日期：2013-06-01 00:00:00

abstract：:A solid-phase platelet membrane enzyme linked immunosorbent assay (ELISA) was developed for the detection of circulating platelet binding IgG in serum. 18 out of 28 (64%) sera from patients with chronic idiopathic thrombocytopenic purpura (ITP) and 10 out of 21 (48%) sera from patients with acute ITP contained more pl...

journal_title：Clinical and experimental immunology

authors： Winiarski J,Ekelund E

更新日期：1986-02-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from a proportion of grass-sensitive patients, studied during or immediately after the grass pollination period, showed spontaneous production in vitro of grass-specific IgE antibody, whereas PBL from atopic patients sensitive to allergens other than grass pollens or non-atopic indiv...

journal_title：Clinical and experimental immunology

authors： Romagnani S,Maggi E,Del Prete GF,Almerigogna F,Biagiotti R,Giudizi MG,Ricci M

更新日期：1982-07-01 00:00:00

abstract：:Neutrophils maintain immune homeostasis by engulfing apoptotic cells and debris. We describe the rapid activation of neutrophils after engulfing hemoglobin (Hb)-activated platelets, which are abundant in the circulation of hemolytic patients. Neutrophils from healthy individuals after engulfing Hb-activated platelets ...

journal_title：Clinical and experimental immunology

authors： Bhasym A,Annarapu GK,Saha S,Shrimali N,Gupta S,Seth T,Guchhait P

更新日期：2019-08-01 00:00:00

abstract：:There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

journal_title：Clinical and experimental immunology

authors： Dickinson AM,George S,Proctor SJ

更新日期：1983-11-01 00:00:00

abstract：:The kinetics of efflux of calcium mobilized from intracellular stores following activation of human neutrophils with the synthetic chemotactic tripeptide, fMLP (1 microM), as well as that of the subsequent store-operated influx of this cation, has been measured by radiometric procedures using 45Ca. These procedures en...

journal_title：Clinical and experimental immunology

authors： Anderson R,Goolam Mahomed A

更新日期：1997-10-01 00:00:00

abstract：:The functional integrity of the local immune system in vitamin A-deficient (A-) rats was investigated. Secretory IgA levels in the intestinal fluid of A- rats were significantly lower than in controls. This and the decrease in intensity of immunofluorescent staining for secretory component (SC) in the intestinal cells...

journal_title：Clinical and experimental immunology

authors： Sirisinha S,Darip MD,Moongkarndi P,Ongsakul M,Lamb AJ

更新日期：1980-04-01 00:00:00

abstract：:Cachexia is one of the prominent features of advanced tuberculosis (TB) seen in association with increased expression of the monokine TNF-alpha. Several mycobacterial proteins, including PPD, stimulate TNF-alpha secretion from monocytes. Host factors that may play a role in cytokine expression from monocytes remain la...

journal_title：Clinical and experimental immunology

authors： Hussain R,Shiratsuchi H,Phillips M,Ellner J,Wallis RS

更新日期：2001-02-01 00:00:00

abstract：:Cytoplasmic free Ca2+ concentration and influx of 86Rb+ (K+ analogue) were determined during the first minutes after stimulation of neoplastic human B cells and B cell lines by antibodies to surface Ig. The Ca2+ concentration increased in the great majority of samples (41 of 48). All of four B cell lines also responde...

journal_title：Clinical and experimental immunology

authors： Heikkilä R,Ruud E,Funderud S,Godal T

更新日期：1985-03-01 00:00:00

abstract：:The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or Th2 cytokines in peripheral blood and bronchoalveolar lavage (BAL). No studies have examined cytokine production by intraepithelial T c...

journal_title：Clinical and experimental immunology

authors： Hodge G,Nairn J,Holmes M,Reynolds PN,Hodge S

更新日期：2007-10-01 00:00:00

abstract：:Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone d...

journal_title：Clinical and experimental immunology

authors： Young DG,Skibinski G,Mason JI,James K

更新日期：1999-09-01 00:00:00

abstract：:The synthesis of some class 1 acute-phase proteins (APP), including C-reactive protein (CRP) and serum amyloid A (SAA) protein is completely blocked by the IL-1 receptor antagonist (IL-1Ra), whereas the production of fibrinogen, a class 2 APP, is increased by IL-1Ra in hepatoma cells, but this has never been tested in...

journal_title：Clinical and experimental immunology

authors： Gabay C,Genin B,Mentha G,Iynedjian PB,Roux-Lombard P,Guerne PA

更新日期：1995-05-01 00:00:00

abstract：:Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell exp...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Mayanja-Kizza H,Baseke J,Peters P,Wu M,Abraha A,Aung H,Okwera A,Hirsch C,Arts E

更新日期：2005-11-01 00:00:00

abstract：:Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of unde...

journal_title：Clinical and experimental immunology

authors： Sfikakis PP,Oglesby R,Sfikakis P,Tsokos GC

更新日期：1994-04-01 00:00:00

abstract：:Anti-tubulin antibodies were studied in normal human serum either maintained at neutral pH to measure the free antibody activity (FAA) or treated at pH 2.8 to measure the total antibody activity (TAA): FAA + the antibody activity in the form of immune complexes (ICAA). Anti-tubulin antibody activities were assessed by...

journal_title：Clinical and experimental immunology

authors： Bernier-Valentin F,Rabilloud R,Rousset B

更新日期：1988-02-01 00:00:00

abstract：:The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied ov...

journal_title：Clinical and experimental immunology

authors： Pocidalo MA,Gibert C,Verroust P,Geniteau M,Adam C,Madec Y,Gaudebout C,Morel-Maroger L

更新日期：1982-03-01 00:00:00

abstract：:Leucocyte adhesion deficiency type 1 (LAD-1) is characterized by the incapacity of leucocytes to carry out their adhesion functions via their CD11/CD18 antigens, which are also referred to as the leucocyte integrins. The patients generally suffer from poor wound healing and recurrent bacterial and fungal infections. I...

journal_title：Clinical and experimental immunology

authors： Mathew EC,Shaw JM,Bonilla FA,Law SK,Wright DA

更新日期：2000-07-01 00:00:00

abstract：:Amyloid obtained from the myocardium of a patient (Han) with familial amyloid cardiomyopathy of Danish origin was studied. Gel filtration and electrophoresis of purified and denatured amyloid fibrils Han revealed various fractions ranging in mol. wt from 40,000 to 8,000 daltons. Amyloid Han and fractions reacted with ...

journal_title：Clinical and experimental immunology

authors： Husby G,Ranløv PJ,Sletten K,Marhaug G

更新日期：1985-04-01 00:00:00

abstract：:A method is described for culturing intact human thyroid follicles, based on the study of 40 thyroidectomy specimens from normal (n = 18) and diseased glands (n = 22). Reversal of the normal polarity of thyrocytes, whereby the microvilli move from the colloid edge to the vascular pole of the cells, occurs gradually wh...

journal_title：Clinical and experimental immunology

authors： Hanafusa T,Pujol-Borrell R,Chiovato L,Doniach D,Bottazzo GF

更新日期：1984-09-01 00:00:00

abstract：:Ox-LDL is thought to play a major role in atherogenesis. The mechanisms mediating the deleterious influences of Ox-LDL include foam cell formation and cell cytotoxicity. The production of anti-Ox-LDL antibodies results in the formation of immune complexes which are taken up at enhanced rate by macrophages, leading to ...

journal_title：Clinical and experimental immunology

authors： George J,Blank M,Hojnik M,Bar-Meir E,Koike T,Matsuura E,Lorber M,Aviram M,Shoenfeld Y

更新日期：1997-05-01 00:00:00

abstract：:There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity w...

journal_title：Clinical and experimental immunology

authors： Fenoy I,Giovannoni M,Batalla E,Martin V,Frank FM,Piazzon I,Goldman A

更新日期：2009-02-01 00:00:00

abstract：:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

journal_title：Clinical and experimental immunology

authors： Bäck O,Lidén S,Ahlstedt S

更新日期：1977-06-01 00:00:00

abstract：:The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats wit...

journal_title：Clinical and experimental immunology

authors： Seno K,Yasunaga M,Kajiya H,Izaki-Hagio K,Morita H,Yoneda M,Hirofuji T,Ohno J

更新日期：2017-12-01 00:00:00

abstract：:Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying the development of inflammatory bowel disease. However, this model cannot be used when therapeutics designed to address human targets do not interact with the respective...

journal_title：Clinical and experimental immunology

authors： Nolte T,Zadeh-Khorasani M,Safarov O,Rueff F,Gülberg V,Herbach N,Wollenberg A,Mueller T,Siebeck M,Wolf E,Gropp R

更新日期：2013-05-01 00:00:00