当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Functional activity of peripheral mononuclear cells in cystic fibrosis: antibodies and plaque formation.

Functional activity of peripheral mononuclear cells in cystic fibrosis: antibodies and plaque formation.

Abstract：

:Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. The ability of peripheral mononuclear cells (MNC) derived from patients with CF to form PFC upon stimulation by pokeweed mitogen was significantly decreased as compared to healthy control individuals (P less than 0 . 01). Levels of serum immunoglobulins of the G, A, and M classes and of sheep red blood cell agglutinating antibodies were estimated as well, but no correlation was obtained between these parameters and the number of PFC in patients with CF.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Götz M,Zielinski CC,Ahmad R,Eibl M

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

178-82

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

50

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Membrane characteristics of established human T- and B-cell lines. Cross-reactivity of human T-antigenic determinants with peripheral lymphocytes of non-human primates and the presence of MLC antigens on cultured T-cell lines.

    abstract：:Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after a...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Takada A,Babbitt H,Hayata I,Takada Y

    更新日期：1976-04-01 00:00:00

  • Mice with early onset of death (EOD) due to lupus glomerulonephritis.

    abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00847.x

    authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

    更新日期：1999-04-01 00:00:00

  • Immunoglobulin abnormalities in Paget's disease of bone.

    abstract：:Several patients with Paget's disease have been reported to have monoclonal IgM proteins in their serum. We have systematically studied 26 patients with Paget's disease severe enough to require diphosphonate therapy. Five of these patients were found to have isolated elevations of serum IgM which were well outside the...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Buxbaum JN,Kammerman S

    更新日期：1984-04-01 00:00:00

  • Renal transplantation in a patient with hereditary deficiency of the second component of complement.

    abstract：:The HLA haplotype A 10,B18 has been associated with hereditary deficiency of the second component of complement(C2). In an effort to detect individuals homozygous for C2 deficiency, a thorough audit of HLA serotyping results in 3,100 individuals was performed, and a single patient homozygous for the A10, B18 haplotype...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Zeitz HJ,Gewurz A,Jonasson O,Geis WP,Gewurz H

    更新日期：1981-11-01 00:00:00

  • Immunoglobulin replacement therapy by self-infusion at home.

    abstract：:Twelve patients, ten with common variable hypogammaglobulinaemia and two with hypogammaglobulinaemia secondary to chronic lymphocytic leukaemia (CLL), have been taught to self-infuse their intravenous immunoglobulin replacement therapy. Follow-up of these patients has shown that regular self-infusion at home is feasib...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Chapel H,Brennan V,Delson E

    更新日期：1988-07-01 00:00:00

  • NK cells modulate the cytotoxic activity generated by Mycobacterium leprae-hsp65 in leprosy patients: role of IL-18 and IL-13.

    abstract：:Protection against intracellular pathogens such as Mycobacterium leprae is critically dependent on the function of NK cells at early stages of the immune response and on Th1 cells at later stages. In the present report we evaluated the role of IL-18 and IL-13, two cytokines that can influence NK cell activity, in the ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02334.x

    authors： de la Barrera S,Finiasz M,Fink S,Ilarregui J,Aleman M,Olivares L,Franco MC,Pizzariello G,del Carmen Sasiain M

    更新日期：2004-01-01 00:00:00

  • Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.

    abstract：:In order to study the role of gamma/delta T cells in the pathogenesis of inflammatory bowel disease (IBD) in humans, we measured the percentage of these cells in the peripheral blood, assessed the ratio of the non-disulphide-linked (delta TCS1) type of T cell receptor (TCR) in the total gamma/delta T cells, studied th...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06611.x

    authors： Giacomelli R,Parzanese I,Frieri G,Passacantando A,Pizzuto F,Pimpo T,Cipriani P,Viscido A,Caprilli R,Tonietti G

    更新日期：1994-10-01 00:00:00

  • Comparison of the immune response against Mycobacterium tuberculosis antigens between a group of patients with active pulmonary tuberculosis and healthy household contacts.

    abstract：:The mycobacterial antigens and the factors related to protection for the development of active tuberculosis are not known. In a natural model of tuberculosis, we studied 10 patients with active pulmonary tuberculosis (non-protective immune response) and 38 healthy household contacts (protective immune response). We te...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06233.x

    authors： Torres M,Mendez-Sampeiro P,Jimenez-Zamudio L,Teran L,Camarena A,Quezada R,Ramos E,Sada E

    更新日期：1994-04-01 00:00:00

  • The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28.

    abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. The increase in serum IgE concentration is clearly measurable by day 4 after the first HgCl2 injection...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01928.x

    authors： Macphee IA,Turner DR,Yagita H,Oliveira DB

    更新日期：2002-09-01 00:00:00

  • Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-assocated markers of immune dysfunction.

    abstract：:We used three-colour cytometry to analyse intracellular cytokine production in activated whole blood cultures derived from patients with HIV-1 infection. We assessed mitogen-induced IL-2, IL-4 and IFN-gamma production from T cells as possible markers of immune dysfunction. The percentages of T cells staining for IL-2 ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00505.x

    authors： Westby M,Marriott JB,Guckian M,Cookson S,Hay P,Dalgleish AG

    更新日期：1998-02-01 00:00:00

  • Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients.

    abstract：:Immunofluorescence (IF) to detect HCV antigens and non-isotopic in situ hybridization (NISH) to detect HCV RNA genome were carried out on bone marrow (BM) and peripheral blood (PB) mononuclear cells (MC) of 11 chronically HCV-infected patients. In four patients (36.4%) HCV antigens were detected in monocytes/macrophag...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1996.tb08296.x

    authors： Sansonno D,Iacobelli AR,Cornacchiulo V,Iodice G,Dammacco F

    更新日期：1996-03-01 00:00:00

  • The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease.

    abstract：:Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Glu...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ciclitira PJ,Nelufer JM,Ellis HJ,Evans DJ

    更新日期：1986-01-01 00:00:00

  • The detection and initial characterization of colony-stimulating factors in synovial fluid.

    abstract：:In this study which included 16 patients with inflammatory or non-inflammatory arthropathies, human granulocyte-macrophage colony-stimulating activity was detected in synovial fluid. This was attributable to the presence of colony-stimulating factor(s) (CSF), as a direct action on human bone marrow progenitor cells wa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Williamson DJ,Begley CG,Vadas MA,Metcalf D

    更新日期：1988-04-01 00:00:00

  • Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

    abstract：:Loss of pancreatic beta-cells in type I diabetes is associated with an increase in T helper 1 (Th1) proinflammatory cytokines in the islet milieu, with a concomitant reduction in Th2 anti-inflammatory cytokines. In animal models, manoeuvres designed to polarize Th1 responses towards Th2, particularly involving interle...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03375.x

    authors： Kaminski A,Kaminski ER,Morgan NG

    更新日期：2007-06-01 00:00:00

  • Unresponsiveness to Con A in spleen cell cultures of M. lepraemurium-infected mice is dependent on a defective expression of high-affinity IL-2 receptors rather than on a lack of IL-2 production.

    abstract：:The production of interleukin-2 (IL-2) by Con A-activated spleen cells (SC) progressively declined and reached negligible values during the course of infection of C57BL/6 mice with Mycobacterium lepraemurium. In addition, the capacity of cultured SC to utilize IL-2 was highly reduced, as demonstrated by the accumulati...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Turcotte R,Lemieux S

    更新日期：1989-04-01 00:00:00

  • Determination of cryoglobulins as lipoprotein-autoantibody immune complexes and antigenic determinants against antilipoprotein autoantibody.

    abstract：:Serum IgG-antilipoprotein-autoantibody activity (at 4 degrees C) of a plane xanthoma patient was shown by double-immunodiffusion method. Cryoglobulins in the serum were dissociated to polyclonal IgG and alpha- and beta-lipoproteins by acidification and were reconstructed by neutralization. IgG fraction of the cryoglob...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kodama H

    更新日期：1977-06-01 00:00:00

  • Elevated numbers of peripheral T cells in inflammatory bowel diseases displaying T9 antigen and Fc alpha receptors.

    abstract：:Elevated numbers of peripheral T cells expressing the activation associated antigen T9 are found in patients with active Crohn's disease. Expression of T9 is found to be correlated to the activity of the disease. However the presence of activated peripheral T cells is not restricted to Crohn's disease, but could also ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Raedler A,Fraenkel S,Klose G,Thiele HG

    更新日期：1985-06-01 00:00:00

  • In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes.

    abstract：:It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Pardi R,Zocchi MR,Ferrero E,Ciboddo GF,Inverardi L,Rugarli C

    更新日期：1984-09-01 00:00:00

  • Rearrangement of the human heavy chain variable region gene V3-23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of VHCDR3 and residues intrinsic to the heavy chain variable region.

    abstract：:To formulate a 'logic' for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the germ-line human V3-23 gene, multiple diversity (D) and joining (J) gene segments. Hybridomas p...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01380.x

    authors： Mageed RA,Harmer IJ,Wynn SL,Moyes SP,Maziak BB,Brüggemann M,MacKworth-Young CG

    更新日期：2001-01-01 00:00:00

  • Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels.

    abstract：:CD4+CD25+ T regulatory cells may play a role in the different clinical presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell responses. Peripheral CD4+CD25+ T cells from chronic HCV carriers with normal and abnormal alanine aminotransferase (ALT) were analysed for specificity and effect...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03048.x

    authors： Bolacchi F,Sinistro A,Ciaprini C,Demin F,Capozzi M,Carducci FC,Drapeau CM,Rocchi G,Bergamini A

    更新日期：2006-05-01 00:00:00

  • The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK-1.

    abstract：:The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by th...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ritchie AW,James K,Micklem HS

    更新日期：1983-03-01 00:00:00

  • Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.

    abstract：:Macaques provide important animal models in biomedical research into infectious and chronic inflammatory disease. Therefore, a proper understanding of the similarities and differences in immune function between macaques and humans is needed for adequate interpretation of the data and translation to the human situation...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12155

    authors： Koopman G,Beenhakker N,Burm S,Bouwhuis O,Bajramovic J,Sommandas V,Mudde G,Mooij P,'t Hart BA,Bogers WM

    更新日期：2013-10-01 00:00:00

  • The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo.

    abstract：:In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb03310.x

    authors： Bloemena E,Weinreich S,Schellekens PT

    更新日期：1990-06-01 00:00:00

  • Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts.

    abstract：:Connective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patients with SSc and hea...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03199.x

    authors： Hong KH,Yoo SA,Kang SS,Choi JJ,Kim WU,Cho CS

    更新日期：2006-11-01 00:00:00

  • Analysis of T cell subsets by monoclonal antibodies in patients with tuberculosis after in vitro stimulation with purified protein derivative of tuberculin.

    abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Shiratsuchi H,Tsuyuguchi I

    更新日期：1984-08-01 00:00:00

  • T lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to Chlamydia antigens.

    abstract：:Chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. To determine whether T lymphocyte-mediated immune responses to Chlamydia antigens within plaque could contribute to pathogenesis, we have derived T cell lines from atherosclerotic plaques of 32 p...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01294.x

    authors： Curry AJ,Portig I,Goodall JC,Kirkpatrick PJ,Gaston JS

    更新日期：2000-08-01 00:00:00

  • An abnormal adherence of monocytes to fibronectin in thyroid autoimmunity has consequences for cell polarization and the development of veiled cells.

    abstract：:Blood monocytes of patients with thyroid autoimmune disease (TAID) display defects in rearranging their cortical actomyosin cytoskeleton ('polarize') in response to chemoattractants. Such rearrangements also take place after the adherence of monocytes to the extracellular matrix (ECM). It is therefore not surprising t...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01583.x

    authors： Canning MO,Grotenhuis K,De Haan-Meulman M,De Wit HJ,Berghout A,Drexhage HA

    更新日期：2001-07-01 00:00:00

  • Evidence that X-linked severe combined immunodeficiency is not a differentiation defect of T lymphocytes.

    abstract：:In order to gain information about the nature of the defect in X-linked severe combined immunodeficiency (XSCID), we investigated gene expression in different lymphoid and haematopoietic cells of female carriers by looking for non-random X chromosome usage. We have shown non-random X chromosome usage in T lymphocyte e...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05579.x

    authors： Goodship J,Malcolm S,Levinsky RJ

    更新日期：1991-01-01 00:00:00

  • Regulation of IgA secretion in polyclonally induced in vitro human lymphocyte cultures: the function of T and B cells from mesenteric lymph nodes and peripheral blood.

    abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

    更新日期：1986-04-01 00:00:00

  • Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes.

    abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells capable of maintaining peripheral tolerance. The possibility to generate tolerogenic DCs opens new therapeutic approaches in the prevention or remission of autoimmunity. There is currently no treatment inducing long-term tolerance and remission in type 1 diab...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2009.04082.x

    authors： Marin-Gallen S,Clemente-Casares X,Planas R,Pujol-Autonell I,Carrascal J,Carrillo J,Ampudia R,Verdaguer J,Pujol-Borrell R,Borràs FE,Vives-Pi M

    更新日期：2010-05-01 00:00:00