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In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes.

Abstract：

:It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL) mitogenic responses have been investigated. PBL from healthy young volunteers who received intravenous aminophylline (5 mg/kg i.v. over 20 min) showed an increased proliferative response to phytohaemagglutinin. This was correlated with an augmented OKT4/OKT8 ratio, due to an absolute increase in the OKT4+ subset as well as a decrease in OKT8+ cells. Furthermore, following in vivo aminophylline we observed a significant rise in lymphocyte cAMP levels. These data, together with studies from other laboratories, suggest that the dosages and duration of treatment may influence greatly the theophylline-induced modulation of immune functions.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Pardi R,Zocchi MR,Ferrero E,Ciboddo GF,Inverardi L,Rugarli C

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

722-8

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

57

pub_type

杂志文章

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