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99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.

Abstract：

:There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. Moreover, this maturation process can have a major impact on early vaccine responses and can be a key determinant of risk for communicable and non-communicable diseases in later life. We hypothesize that environmental and genetic factors that are often typical for poor-resource countries may have an important impact on prenatal immune development and predispose populations in low-income settings to different vaccine responses and disease risks, compared to those living in high-income countries. In this paper we aimed to summarize the major differences between neonatal and adult immune function and describe what is known so far about discrepancies in immune function between newborns in high- and low-income settings. Further, we discuss the need to test the immunological feasibility of accelerated vaccination schedules in high-risk populations and the potential of variation in disease specific and non-specific vaccine effects.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

van den Biggelaar AH,Holt PG

doi

10.1111/j.1365-2249.2010.04137.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

42-7

issue

1

eissn

0009-9104

issn

1365-2249

pii

CEI4137

journal_volume

160

pub_type

杂志文章

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