Expression of types I, III and IV collagen genes in fibrotic skin and nerve lesions of toxic oil syndrome patients.

Abstract:

:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cells within the fibrotic process of the nerves. These results suggest that the excessive accumulation of collagen in toxic oil syndrome results from transcriptional activation of collagen genes in a subpopulation of fibroblasts.

journal_name

Clin Exp Immunol

authors

Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

doi

10.1111/j.1365-2249.1993.tb06504.x

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

103-7

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

93

pub_type

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