当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Human neutrophil Fc receptor-mediated adhesion under flow: a hollow fibre model of intravascular arrest.

Human neutrophil Fc receptor-mediated adhesion under flow: a hollow fibre model of intravascular arrest.

Abstract：

:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. Under conditions of flow mimicking those in a small vessel, PMN were found to adhere markedly only to immunoglobulin-coated fibres. Arrest on HAIgG was inhibited by excess soluble IgG but not by bovine serum albumin (BSA), demonstrating that the adhesion was IgG-specific and presumably mediated by Fc gamma R on the PMN surface. Pre-adsorption of serum components onto HAIgG-coated fibres enhanced PMN arrest, due most probably to fixation of complement components by immobilized HAIgG, resulting in additional potential to entrap PMN via complement receptors such as CR3. Treatment of PMN with the regulatory neuropeptide substance P also enhanced adhesion to HAIgG-coated fibres and caused increased surface expression of Fc gamma RI, Fc gamma RII and Fc gamma RIII. A mouse cell line derived from L cells, hR4C6, stably transfected with human Fc gamma RII, was found to adhere under flow to HAIgG-coated fibres, whilst untransfected parent L cells did not. This adhesion was similarly inhibited by excess soluble IgG, confirming the capability of Fc gamma R to mediate cell arrest. The study strongly suggests that Fc gamma R may play an important role in intravascular PMN arrest and we speculate that in inflammatory diseases PMN may adhere via Fc gamma R to immobilized immunoglobulin on the vascular endothelium, with subsequent degranulation and tissue damage.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

doi

10.1111/j.1365-2249.1995.tb03620.x

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

173-9

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

100

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Acute-phase protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6.

    abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05666.x

    authors： Raynes JG,Eagling S,McAdam KP

    更新日期：1991-03-01 00:00:00

  • The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.

    abstract：:The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rook GA

    更新日期：1975-07-01 00:00:00

  • IgM levels and IgM-mediated immune responses in patients with acute hepatitis A, acute hepatitis B and chronic HB antigenaemia.

    abstract：:Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dietz WH Jr,Porcell O,Moon TE,Peters CJ,Purcell RH

    更新日期：1976-01-01 00:00:00

  • Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes.

    abstract：:Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ma DD,Ho AH,Hoffbrand AV

    更新日期：1984-02-01 00:00:00

  • Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals.

    abstract：:Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodula...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12026

    authors： Chéramy M,Hampe CS,Ludvigsson J,Casas R

    更新日期：2013-03-01 00:00:00

  • Tumour necrosis factor, IL-1 and IL-6 in bronchoalveolar washings and their in vitro production during Nippostrongylus brasiliensis infection.

    abstract：:Bronchoalveolar washings (BAW) were obtained from rats primarily infected with N. brasiliensis during the early infection stage that coincides with the lung passage of the parasite and the recruitment of inflammatory cells. BAW were tested for IL-1, IL-6 and tumour necrosis factor (TNF) activities. We found that IL-1 ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb03071.x

    authors： Benbernou N,Matsiota-Bernard P,Jolivet C,Ougen P,Guenounou M

    更新日期：1992-05-01 00:00:00

  • Endothelial tissue factor stimulation by proteinase 3 and elastase.

    abstract：:In ANCA-associated vasculitis the activation of primed leucocytes by autoantibodies with subsequent release of proteases such as myeloperoxidase (MPO), proteinase 3 (PR3) and elastase is thought to play an important pathogenetic role. Whether these proteases contribute to the vascular lesions by stimulating the procoa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01587.x

    authors： Haubitz M,Gerlach M,Kruse HJ,Brunkhorst R

    更新日期：2001-12-01 00:00:00

  • Specific activation of resting T cells against tumour cells by bispecific antibodies and CD28-mediated costimulation is accompanied by Th1 differentiation and recruitment of MHC-independent cytotoxicity.

    abstract：:Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.3481245.x

    authors： Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

    更新日期：1997-05-01 00:00:00

  • Autoantibodies from mixed cryoglobulinaemia patients bind glomerular antigens.

    abstract：:Mixed cryoglobulinaemia (MC) is a disorder characterized by the presence of large amounts of cryoprecipitating IgM-IgG complexes. An immune complex glomerulonephritis develops in one third of all patients, but its occurrence does not seem related to the amount of cryoglobulins in the sera, nor to their complement-fixi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06560.x

    authors： Dolcher MP,Marchini B,Sabbatini A,Longombardo G,Ferri C,Riente L,Bombardieri S,Migliorini P

    更新日期：1994-05-01 00:00:00

  • Increased CD11/CD18 expression on peripheral blood leucocytes of patients with sarcoidosis.

    abstract：:Sarcoidosis is a multisystem disease of unknown etiology characterized by non-caseating granulomata, formed mainly from macrophages surrounded by lymphocytes and plasma cells. Using a novel method for the preparation of blood leucocytes for flow cytometry, we report increased expression of LeuCAMs (CD11/CD18) on perip...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb05839.x

    authors： Shakoor Z,Hamblin AS

    更新日期：1992-10-01 00:00:00

  • Renal damage and death in weaned mice after oral infection with Shiga toxin 2-producing Escherichia coli strains.

    abstract：:Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infections are considered a public health problem in both developed and developing countries because of their increasing incidence and the severity of clinical presentation. Approximately 10% of infected patients develop complications such as haemolytic uraemic syndro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03698.x

    authors： Brando RJ,Miliwebsky E,Bentancor L,Deza N,Baschkier A,Ramos MV,Fernández GC,Meiss R,Rivas M,Palermo MS

    更新日期：2008-08-01 00:00:00

  • Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

    abstract：:In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2009.04039.x

    authors： Koenders MI,van den Berg WB

    更新日期：2010-02-01 00:00:00

  • Anti-atherogenic peptide Ep1.B derived from apolipoprotein E induces tolerogenic plasmacytoid dendritic cells.

    abstract：:Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12370

    authors： Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

    更新日期：2014-09-01 00:00:00

  • Electrophoresis of lymphoid cells. Differences in the cell membrane structure of murine thymocytes, T and B cells revealed by enzyme and formalin treatment.

    abstract：:Low concentrations of protease and trypsin reduced the electrophoretic mobility (EPM) of thymocytes; with higher concentrations it was normal or above. Differences in membrane structure of thymocytes, T and B cells was found as B cells showed no reduction while T cells gave intermediate values. Further the reduction w...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Wiig JN

    更新日期：1975-10-01 00:00:00

  • Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells.

    abstract：:In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05818.x

    authors： Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

    更新日期：1991-11-01 00:00:00

  • Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: correlation with clinical stages of the disease.

    abstract：:The distribution of T lymphocyte subsets was assessed using monoclonal antibodies (MoAbs) in 44 untreated patients with multiple myeloma (MM) subdivided according to the clinical stage of the disease. A significant reduction (P less than 0.001) of T lymphocytes was observed only in stage II and III patients. The propo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Lauria F,Foa R,Cavo M,Gobbi M,Raspadori D,Giubellino MC,Tazzari PL,Tura S

    更新日期：1984-06-01 00:00:00

  • PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation.

    abstract：:Proliferation of mesangial cells is a hallmark of glomerular disease, and understanding the regulatory mechanisms is critically important. The purpose of this study was to examine the relationship between mesangial cell proliferation and phosphorylated signal transducer and activator of transcription (STAT) 3 and to d...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03073.x

    authors： Hirai T,Masaki T,Kuratsune M,Yorioka N,Kohno N

    更新日期：2006-05-01 00:00:00

  • Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis.

    abstract：:Data from a previous study suggested that peripheral blood monocytes in patients with rheumatoid arthritis (RA) may be activated. Therefore, in this study we sought further evidence of 'presynovial' activation of monocytes. Our results show that phenotypic changes are demonstrable in peripheral blood monocytes in pati...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb03850.x

    authors： Highton J,Carlisle B,Palmer DG

    更新日期：1995-12-01 00:00:00

  • Reduced mitogenic responses in cultures of lymphocytes from newly calved cows.

    abstract：:The proliferative responses to stimulation with phytohaemagglutinin (PHA) in cultures of lymphocytes from newly calved and non-pregnant cattle were compared. Lymphocyte cultures from newly calved cows were seen to respond less to PHA than cultures from the non-pregnant cows. It is suggested that this depression in res...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Wells PW,Burrells C,Martin WB

    更新日期：1977-07-01 00:00:00

  • Characterization of different types of experimental autoimmune thyroiditis in the Buffalo strain rat.

    abstract：:We have compared features of experimental thyroiditis in the Buffalo strain rat induced by neonatal thymectomy, immunization with rat thyroglobulin (Tg) and complete Freund's adjuvant, and subcutaneous administration of trypan blue or 3-methylcholanthrene. The disease produced by neonatal thymectomy resulted in signif...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Cohen SB,Weetman AP

    更新日期：1987-07-01 00:00:00

  • A new haemolytic assay for the second component of complement (C2) in human serum.

    abstract：:A new, specific haemolytic assay for C2 is described using EAC43 (Antrypol) cells and serum deficient in C4 and C2 from a patient with hereditary angio-oedema. The method is simple and the results in pathological and normal sera correlate well with those obtained using the EA and C2-deficient serum method. ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Naish PF,Barratt J,Collins C

    更新日期：1976-09-01 00:00:00

  • CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response.

    abstract：:The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CA...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12275

    authors： Wang H,Zhao J,Zhang H,Huang Y,Wang S,Tu Q,Yang N

    更新日期：2014-05-01 00:00:00

  • Immunostimulating activities of the novel peptidomimetic L-glutamyl-histamine.

    abstract：:An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02710.x

    authors： Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

    更新日期：2005-03-01 00:00:00

  • Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers.

    abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal regulatory T cell (T(reg)) response and increases in T helper type 1 (Th1) and Th17 cell responses. It is unclear if dysregulation of microRNAs (miRNA) within T(reg) cells contributes to the abnormal inflammatory response in COPD. In this stu...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12325

    authors： Chatila WM,Criner GJ,Hancock WW,Akimova T,Moldover B,Chang JK,Cornwell W,Santerre M,Rogers TJ

    更新日期：2014-07-01 00:00:00

  • Membrane characteristics of established human T- and B-cell lines. Cross-reactivity of human T-antigenic determinants with peripheral lymphocytes of non-human primates and the presence of MLC antigens on cultured T-cell lines.

    abstract：:Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after a...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Takada A,Babbitt H,Hayata I,Takada Y

    更新日期：1976-04-01 00:00:00

  • Calcium efflux and influx in f-met-leu-phe (fMLP)-activated human neutrophils are chronologically distinct events.

    abstract：:The kinetics of efflux of calcium mobilized from intracellular stores following activation of human neutrophils with the synthetic chemotactic tripeptide, fMLP (1 microM), as well as that of the subsequent store-operated influx of this cation, has been measured by radiometric procedures using 45Ca. These procedures en...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.5051403.x

    authors： Anderson R,Goolam Mahomed A

    更新日期：1997-10-01 00:00:00

  • Modulation of CD4⁺ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis.

    abstract：:Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2011.04393.x

    authors： Hashimoto N,Shimoda S,Kawanaka H,Tsuneyama K,Uehara H,Akahoshi T,Kinjo N,Taketomi A,Shirabe K,Akashi K,Lleo A,Ansari AA,Gershwin ME,Maehara Y

    更新日期：2011-08-01 00:00:00

  • Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients.

    abstract：:The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC fr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06044.x

    authors： Kurtzhals JA,Hey AS,Jardim A,Kemp M,Schaefer KU,Odera EO,Christensen CB,Githure JI,Olafson RW,Theander TG

    更新日期：1994-06-01 00:00:00

  • Analysis of immunoglobulin G in multiple sclerosis brain: quantitative and isoelectric focusing studies.

    abstract：:Immunoglobulin G (IgG) in soluble and particulate fractions of discrete tissue samples from multiple sclerosis (MS) brain was analysed. Supernatant IgG/albumin rations and particulate-bound IgG levels were highest in samples dissected from MS plaques and adjacent white matter. Acid extracts of particulate fractions fr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Glynn P,Gilbert HM,Newcombe J,Cuzner ML

    更新日期：1982-04-01 00:00:00

  • Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody.

    abstract：:Reliable risk assessment for biotherapeutics requires accurate evaluation of risk factors associated with immunogenicity. Immunogenicity risk assessment tools were developed and applied to investigate the immunogenicity of a fully human therapeutic monoclonal antibody, ATR-107 [anti-interleukin (IL)-21 receptor] that ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12711

    authors： Xue L,Hickling T,Song R,Nowak J,Rup B

    更新日期：2016-01-01 00:00:00