The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo.

abstract：:Many patients surviving vasculitis are prone to accelerated atherosclerosis and often have enhanced levels of antibodies to oxidized low-density lipoprotein (oxLDL). To measure anti-oxLDL antibodies, oxidation of LDL is achieved with copper (Cu) or malondialdehyde (MDA). Because, in vivo, LDL may be oxidized with myel...

journal_title：Clinical and experimental immunology

authors： Slot MC,Theunissen R,van Paassen P,Damoiseaux JG,Tervaert JW,Limburg Nephrology Working Group.

更新日期：2007-08-01 00:00:00

abstract：:The role of complement has been studied in the autologous phase of nephrotoxic nephritis (NTN) in rabbits. No reduction in glomerular fibrin deposition, crescent formation or protection from renal failure was observed in either the standard model of NTN when decomplementing doses of cobra venom factor (CVF) were given...

journal_title：Clinical and experimental immunology

authors： Thomson NM,Naish PF,Simpson IJ,Peters DK

更新日期：1976-06-01 00:00:00

abstract：:A 3.5 year old boy with X-linked severe combined immunodeficiency disease (SCID), who had been in laminar flow isolation throughout his life, developed a B cell tumour producing up to 3008 mg/dl of an IgM kappa paraprotein 1 month after infusion of both liver and thymus cells from a fetal donor and 6 months after the ...

journal_title：Clinical and experimental immunology

authors： Shirley LR,Buckley RH,Borowitz MJ,Welt SI,Kostyu DD

更新日期：1982-06-01 00:00:00

abstract：:Clustering activity for neutrophil granulocytes was generated in pooled normal human serum (NHS) by incubation of the serum with preformed IgG aggregates, but not in heat-treated NHS (56 degrees C, 30 min), indicating that the function was complement-dependent. Judging from results of experiments with complement-defic...

journal_title：Clinical and experimental immunology

authors： Sturfelt G,Jonsson H,Hellmer G,Sjöholm AG

更新日期：1993-08-01 00:00:00

abstract：:Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism in BALB/c mice. In contrast, mice of the same strain vaccinated with TSHR-DNA have low or absent TSHR antibodies and their T cells recognize restricted epitopes on t...

journal_title：Clinical and experimental immunology

authors： Pichurin PN,Chen CR,Nagayama Y,Pichurina O,Rapoport B,McLachlan SM

更新日期：2004-03-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement, are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either...

journal_title：Clinical and experimental immunology

authors： Kerbel RS,Birbeck MS,Robertson D,Cartwright P

更新日期：1975-04-01 00:00:00

abstract：:Previous studies demonstrated that NK resistant Epstein-Barr virus (EBV) carrying human lymphoblastoid cell lines become sensitive to NK cell-mediated destruction following induction of the viral cycle by superinfection with the P3HR-1 substrain of EBV or chemicals. In the present report we analysed the cellular membr...

journal_title：Clinical and experimental immunology

authors： Blazar BA,Fitzgerald J,Sutton L,Strome M

更新日期：1983-10-01 00:00:00

abstract：:We describe two brothers with marked leucopenia, lymphopenia, no immunologicl response to infections (no Ig production, negative PHA response and very low number of T and B lymphocytes in peripheral blood) and hypocellular marrow. They died at 12 and 8 days of life with infection (E. coli and Klebsiella, respectively)...

journal_title：Clinical and experimental immunology

authors： Español T,Compte J,Alvarez C,Tallada N,Laverde R,Peguero G

更新日期：1979-12-01 00:00:00

abstract：:A complement fixing, non-organ specific IgG autoantibody is described in 29 patients. The autoantibody gives a highly characteristic, granular staining of liver cells, proximal kidney tubules and stomach surface epithelium. By studies with various subcellular fractions from rat liver, employing two different technique...

journal_title：Clinical and experimental immunology

authors： Holm R,Gaarder PI,Helgeland L,Falkenhaug EI

更新日期：1985-08-01 00:00:00

abstract：:We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

journal_title：Clinical and experimental immunology

authors： Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

更新日期：1994-03-01 00:00:00

abstract：:Increased stimulation of Th2 cytokines may contribute to the development of persistent ocular chlamydial infection, resulting in the blinding pathological changes of trachoma. Proliferation and cytokine production profiles of PBMC in response to stimulation with antigens of Chlamydia trachomatis were compared in 30 pa...

journal_title：Clinical and experimental immunology

authors： Holland MJ,Bailey RL,Conway DJ,Culley F,Miranpuri G,Byrne GI,Whittle HC,Mabey DC

更新日期：1996-09-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:The prevalence of atopic diseases in children has increased during the last decades. Atopic symptoms usually appear early in life. This implies an early priming for atopic disease, possibly even at the fetal level. We therefore compared the presence and production of IgE in the local in utero environment during pregna...

journal_title：Clinical and experimental immunology

authors： Sverremark Ekstrom E,Nilsson C,Holmlund U,van der Ploeg I,Sandstedt B,Lilja G,Scheynius A

更新日期：2002-02-01 00:00:00

abstract：:Autoantibodies to EEA1 have been described in patients with neurological diseases, subacute cutaneous lupus and a variety of other conditions, including a patient with Wegener's granulomatosis (WG). EEA1 is a hydrophilic peripheral membrane protein transiently associated with the cytoplasmic face of early endosomes. A...

journal_title：Clinical and experimental immunology

authors： Selak S,Woodman RC,Fritzler MJ

更新日期：2000-12-01 00:00:00

abstract：:Factors involved in the production of autoimmune thyroiditis in thymectomized and sublethally irradiated rats were investigated. The study suggested that a gene linked to RT1 of the rat major histocompatibility complex (MHC), a selective depletion of suppressor T cells and high radiosensitivity of the thyroid gland we...

journal_title：Clinical and experimental immunology

authors： Kotani T,Komuro K,Yoshiki T,Itoh T,Aizawa M

更新日期：1981-08-01 00:00:00

abstract：:Synovial fluids from rheumatoid arthritis (RA) patients were found to contain activated T lymphocytes that could be maintained as continuous T cell lines (CTCL) in the presence of the T cell growth factor, interleukin (IL)-2. The CTCL predominantly expressed the OKT8 phenotype and were Ia antigen positive. IL-2-depend...

journal_title：Clinical and experimental immunology

authors： Wilkins JA,Olivier SL,Warrington RJ

更新日期：1984-10-01 00:00:00

abstract：:Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centr...

journal_title：Clinical and experimental immunology

authors： Timonen T,Stenius-Aarniala B

更新日期：1985-01-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is characterized by defective cellular transport of the dibasic amino acids, secondary dysfunction of the urea cycle, aversion to dietary protein, failure to thrive, hepatosplenomegaly and osteoporosis. Because several patients have suffered from recurrent respiratory infections and...

journal_title：Clinical and experimental immunology

authors： Lukkarinen M,Parto K,Ruuskanen O,Vainio O,Käyhty H,Olander RM,Simell O

更新日期：1999-06-01 00:00:00

abstract：:In a study of 75 alveolar cell co-cultures from 55 HIV-seropositive subjects, p24 antigen production was identified by ELISA in 11 out of 26 (42%) of unseparated cell cultures, 15 out of 39 (38%) purified alveolar macrophage cultures and eight out of 10 purified alveolar lymphocyte samples. Positivity in unseparated c...

journal_title：Clinical and experimental immunology

authors： Jeffrey AA,Israël-Biet D,Andrieu JM,Even P,Venet A

更新日期：1991-06-01 00:00:00

abstract：:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

journal_title：Clinical and experimental immunology

authors： Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

更新日期：1984-12-01 00:00:00

abstract：:Supernatants of both CD4+ and CD8+ alloreactive T cell clones induced IgM, IgG and IgA synthesis by peripheral blood lymphocytes (PBL) of healthy donors in vitro. These supernatants were also tested on their capacity to induce immunoglobulin production by PBL of four patients with CVI and one patient with CVI and thym...

journal_title：Clinical and experimental immunology

authors： Pastorelli G,Roncarolo MG,Touraine JL,Rousset F,Pene J,de Vries JE

更新日期：1989-12-01 00:00:00

abstract：:A blood sample was taken from children aged 13-15 years immediately before BCG vaccination and 8 weeks after. The children were tuberculin skin-test negative to PPD-S before vaccination and positive after. Mononuclear cells were separated from the blood, infected with Mycobacterium microti at a low bacterium/monocyte ...

journal_title：Clinical and experimental immunology

authors： Cheng SH,Walker L,Poole J,Aber VR,Walker KB,Mitchison DA,Lowrie DB

更新日期：1988-10-01 00:00:00

abstract：:Complement receptor 1-related gene/protein y (Crry) is a potent murine complement regulator that inhibits C3 convertases. Transgenic mice that overexpress soluble Crry (sCrry), directed systemically by the metallothionein-I promoter, have been used as an animal model for chronic blockade of complement activation. Rece...

journal_title：Clinical and experimental immunology

authors： Kang HJ,Bao L,Xu Y,Quigg RJ,Giclas PC,Holers VM

更新日期：2004-05-01 00:00:00

abstract：:Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy d...

journal_title：Clinical and experimental immunology

authors： Levy E,Ambrus J,Kahl L,Molina H,Tung K,Holers VM

更新日期：1992-11-01 00:00:00

abstract：:Haemorrhage produces alterations in macrophage, T and B cell function. In order to better define the mechanism for the effects of blood loss on immune response, we examined function of and cytokine production by purified T cells, CD4+ and CD8+ subpopulations after blood loss. Whereas T and CD4+ cells from control, unh...

journal_title：Clinical and experimental immunology

authors： Abraham E,Chang YH

更新日期：1992-12-01 00:00:00

abstract：:Cellular immune responses against the oncoantigen anaplastic lymphoma kinase (ALK) in patients with ALK-positive anaplastic large cell lymphoma (ALCL) have been detected using peptide-based approaches in individuals preselected for human leucocyte antigen (HLA)-A*02:01. In this study, we aimed to evaluate nucleophosmi...

journal_title：Clinical and experimental immunology

authors： K Singh V,Werner S,Hackstein H,Lennerz V,Reiter A,Wölfel T,Damm-Welk C,Woessmann W

更新日期：2016-10-01 00:00:00

abstract：:The administration of the polyclonal activator HgCl2 (1 mg/kg i.p.) to Brown Norway (BN) rats on days 0, 2, 4 and 7 resulted in the cyclical production of anti-glomerular basement membrane (GBM) antibodies, the first peak of which occurred at day 14 with a smaller peak at day 26. Glomerular anti-GBM antibody levels we...

journal_title：Clinical and experimental immunology

authors： Savige JA,Lockwood CM

更新日期：1987-12-01 00:00:00

abstract：:During the innate immune response against infections, Natural Killer (NK) cells are as important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic stimulation in the adaptative response. NK cells increase in numbers, after viral infection or vaccination. We investigated the NK cell and CD8 ...

journal_title：Clinical and experimental immunology

authors： Azeredo EL,De Oliveira-Pinto LM,Zagne SM,Cerqueira DI,Nogueira RM,Kubelka CF

更新日期：2006-02-01 00:00:00

abstract：:Autoimmune diseases are either tissue-specific like multiple sclerosis (MS) or multisystemic like systemic lupus erythematosus (SLE), although clinically both exhibit common features. To gain insight into the properties of the genes involved in each disease we have investigated the gene expression signature of periphe...

journal_title：Clinical and experimental immunology

authors： Mandel M,Gurevich M,Pauzner R,Kaminski N,Achiron A

更新日期：2004-10-01 00:00:00