Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts.

abstract：:During the innate immune response against infections, Natural Killer (NK) cells are as important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic stimulation in the adaptative response. NK cells increase in numbers, after viral infection or vaccination. We investigated the NK cell and CD8 ...

journal_title：Clinical and experimental immunology

authors： Azeredo EL,De Oliveira-Pinto LM,Zagne SM,Cerqueira DI,Nogueira RM,Kubelka CF

更新日期：2006-02-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, local and systemic bone loss and a lack of compensatory bone repair. Fibroblast-like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA. An increasing body of evide...

journal_title：Clinical and experimental immunology

authors： Wehmeyer C,Pap T,Buckley CD,Naylor AJ

更新日期：2017-07-01 00:00:00

abstract：:New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, ...

journal_title：Clinical and experimental immunology

authors： Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

更新日期：2001-11-01 00:00:00

abstract：:Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and i...

journal_title：Clinical and experimental immunology

authors： Blom AM,Volokhina EB,Fransson V,Strömberg P,Berghard L,Viktorelius M,Mollnes TE,López-Trascasa M,van den Heuvel LP,Goodship TH,Marchbank KJ,Okroj M

更新日期：2014-10-01 00:00:00

abstract：:Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system and are capable of initiating immune responses in vitro and in vivo. One of the great challenges in immunotherapy protocols is to introduce relevant antigens into DC for stimulation of major histocompatibility complex (MHC) cl...

journal_title：Clinical and experimental immunology

authors： Ponsaerts P,Van Tendeloo VF,Berneman ZN

更新日期：2003-12-01 00:00:00

abstract：:Children receiving anti-leukaemic therapy often become susceptible to severe herpesvirus infection. To investigate specific immunity to herpes simplex virus (HSV) in patients with acute lymphoblastic leukaemia (ALL), in first remission and receiving maintenance chemotherapy, we measured their HSV specific T responder ...

journal_title：Clinical and experimental immunology

authors： Tellez PA,Odom L,Hayward AR

更新日期：1985-12-01 00:00:00

abstract：:Our study aimed to determine the functional activity of different osteoclast progenitor (OCP) subpopulations and signals important for their migration to bone lesions, causing local and systemic bone resorption during the course of collagen-induced arthritis in C57BL/6 mice. Arthritis was induced with chicken type II ...

journal_title：Clinical and experimental immunology

authors： Ikić Matijašević M,Flegar D,Kovačić N,Katavić V,Kelava T,Šućur A,Ivčević S,Cvija H,Lazić Mosler E,Kalajzić I,Marušić A,Grčević D

更新日期：2016-12-01 00:00:00

abstract：:In view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (TGF) beta 1 to down-regulate immune responses in vivo. Preliminary experiments suggested that, at the doses used, systemic injection of soluble TGF beta 1 could not affect bacterial-i...

journal_title：Clinical and experimental immunology

authors： Strassmann G,Bertolini DR,Eidelman O

更新日期：1991-12-01 00:00:00

abstract：:Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic mar...

journal_title：Clinical and experimental immunology

authors： Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens W

更新日期：2003-01-01 00:00:00

abstract：:Human peripheral blood lymphocytes were examined for rosette formation with autologous erythrocytes. When normal human lymphocytes were stimulated with phorbol myristate acetate (PMA) in the presence of autologous serum, the levels of autorosette forming cells (ARFC) were strongly enhanced. Pre-culture was necessary f...

journal_title：Clinical and experimental immunology

authors： Sakano T,Hyodo S,Kittaka E,Tanaka Y,Usui T

更新日期：1982-09-01 00:00:00

abstract：:Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

journal_title：Clinical and experimental immunology

authors： Arnaiz-Villena A,Roitt IM

更新日期：1975-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

journal_title：Clinical and experimental immunology

authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

更新日期：2017-05-01 00:00:00

abstract：:The present standard of care for B cell non-Hodgkin's lymphoma includes the anti-CD20 monoclonal antibody rituximab. Although combination treatments with chemotherapy and rituximab improved the duration of remissions and overall survival in indolent B cell lymphoma, the disease is essentially incurable. Thus, new ther...

journal_title：Clinical and experimental immunology

authors： Manzur S,Cohen S,Haimovich J,Hollander N

更新日期：2012-12-01 00:00:00

abstract：:We used three-colour cytometry to analyse intracellular cytokine production in activated whole blood cultures derived from patients with HIV-1 infection. We assessed mitogen-induced IL-2, IL-4 and IFN-gamma production from T cells as possible markers of immune dysfunction. The percentages of T cells staining for IL-2 ...

journal_title：Clinical and experimental immunology

authors： Westby M,Marriott JB,Guckian M,Cookson S,Hay P,Dalgleish AG

更新日期：1998-02-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

journal_title：Clinical and experimental immunology

authors： Jennings JG,Chang L,Savige JA

更新日期：1994-02-01 00:00:00

abstract：:Antibodies to extractable nuclear antigens (ENA) were analysed in the sera of fifty-two patients with severe rheumatoid arthritis (RA) who were divided into two categories: twenty-five with arthritis only and twenty-seven with extra-articular disease. Using haemagglutination, counterimmunoelectropheresis (CIE) and dou...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Erhardt CC,Maini RN

更新日期：1980-01-01 00:00:00

abstract：:Previous studies demonstrated that NK resistant Epstein-Barr virus (EBV) carrying human lymphoblastoid cell lines become sensitive to NK cell-mediated destruction following induction of the viral cycle by superinfection with the P3HR-1 substrain of EBV or chemicals. In the present report we analysed the cellular membr...

journal_title：Clinical and experimental immunology

authors： Blazar BA,Fitzgerald J,Sutton L,Strome M

更新日期：1983-10-01 00:00:00

abstract：:Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin, ICAM-1, VCAM-1 and E-selectin are of particular interest. However, only thrombomodulin showed the expected close correlation. ...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Raeth U,Scherbaum WA,Galle PR,Stremmel W

更新日期：2000-01-01 00:00:00

abstract：:Serum IgG-antilipoprotein-autoantibody activity (at 4 degrees C) of a plane xanthoma patient was shown by double-immunodiffusion method. Cryoglobulins in the serum were dissociated to polyclonal IgG and alpha- and beta-lipoproteins by acidification and were reconstructed by neutralization. IgG fraction of the cryoglob...

journal_title：Clinical and experimental immunology

authors： Kodama H

更新日期：1977-06-01 00:00:00

abstract：:Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make an...

journal_title：Clinical and experimental immunology

authors： Sorrell TC,Forbes IJ

更新日期：1975-05-01 00:00:00

abstract：:Functional analysis of single Toll-like receptors (TLRs) in vivo is necessary to understand how they shape the ocular inflammation involved in uveitis. In this study we explored the role and mechanisms of TLR-2 agonists on the autoreactive T helper type 17 (Th17) response in experimental autoimmune uveitis (EAU). Trea...

journal_title：Clinical and experimental immunology

authors： Wei R,Dong L,Xiao Q,Sun D,Li X,Nian H

更新日期：2014-11-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:In vitro monoclonal immunoglobulin (mIg) production of cultured tumour cells--prepared from the bone marrow (BM) or from the peripheral blood (PB) of 40 multiple myeloma (MM) patients, 16 patients with monoclonal gammopathy of undetermined significance and two patients with M. Waldenström--was measured with an enzyme-...

journal_title：Clinical and experimental immunology

authors： Peest D,Gasch S,Thiele C,Bartels B,Brunkhorst U,Dallmann I,Hoffmann M,Schedel I,Deicher H

更新日期：1986-07-01 00:00:00

abstract：:Calf sub-mandibular lymph node lymphocytes and human peripheral blood lymphocytes were oxidized by NaIO4. In liquid cell cultures, both types of cells were transformed with enhanced DNA synthesis. In mixed lymphocyte cultures, untreated human lymphocytes were transformed by irradiated-oxidized human cells. However, un...

journal_title：Clinical and experimental immunology

authors： Presant CA,Parker S

更新日期：1977-01-01 00:00:00

abstract：:The localization of antigens reacting with parietal cell antibodies found in the sera of some patients with pernicious anaemia was studied by the indirect immunoperoxidase method on viable gastric glands isolated from the mouse or human fundus by collagenase digestion. We observed that only the luminal surface of pari...

journal_title：Clinical and experimental immunology

authors： Duchateau A,Zeitoun P

更新日期：1983-08-01 00:00:00

abstract：:The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patien...

journal_title：Clinical and experimental immunology

authors： Frostegård AG,Hua X,Su J,Carrero JJ,Heimbürger O,Bárány P,Stenvinkel P,Frostegård J

更新日期：2013-12-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:Benznidazole (BZL) is a nitroheterocyclic drug employed in the chemotherapy of Chagas' disease, a protozoan disease caused by Trypanosoma cruzi. Because this parasite mostly replicates in macrophages, we investigated whether BZL was likely to modify the synthesis of macrophage mediators such as nitrite, tumour necrosi...

journal_title：Clinical and experimental immunology

authors： Revelli S,Le Page C,Piaggio E,Wietzerbin J,Bottasso O

更新日期：1999-11-01 00:00:00

abstract：:A method is described for culturing intact human thyroid follicles, based on the study of 40 thyroidectomy specimens from normal (n = 18) and diseased glands (n = 22). Reversal of the normal polarity of thyrocytes, whereby the microvilli move from the colloid edge to the vascular pole of the cells, occurs gradually wh...

journal_title：Clinical and experimental immunology

authors： Hanafusa T,Pujol-Borrell R,Chiovato L,Doniach D,Bottazzo GF

更新日期：1984-09-01 00:00:00