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Prevalence in myositis of antibodies recognizing anti-U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin.

Abstract：

:New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, which were not precipitated by normal serum or serum positive for antifibrillarin antibodies. Three of the four PM/DM patients had other identified autoantibodies including anti-PL-12 antibodies, antihistone antibodies (AHA), anti-SS-A antibodies and anti-SS-B antibodies defined by double immunodiffusion, ELISA or RNA immunoprecipitation, although there were no significant correlations between anti-Myo 22/25 antibodies and clinical or laboratory findings. There may be a subgroup of PM/DM patients whose sera are positive for anti-Myo 22/25 antibodies.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

doi

10.1046/j.1365-2249.2001.01650.x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

339-44

issue

2

eissn

0009-9104

issn

1365-2249

pii

1650

journal_volume

126

pub_type

杂志文章

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