Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy.

abstract：:Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and an...

journal_title：Clinical and experimental immunology

authors： Passos LSA,Magalhães LMD,Soares RP,Marques AF,Nunes MDCP,Gollob KJ,Dutra WO

更新日期：2017-10-01 00:00:00

abstract：:We have previously used the antibody-mediated binding of bacteria to identify Ig-bearing cells and the natural binding of bacteria to identify several lymphocyte subpopulations. By using bacteria this identification can be carried out in conventional blood smears since bacteria are small and easily distinguished from ...

journal_title：Clinical and experimental immunology

authors： Bratescu A,Mayer E,Teodorescu M

更新日期：1980-09-01 00:00:00

abstract：:The interaction of cationic proteins with IgG, IgA and IgM were investigated by solid phase radioimmunoassay. All these immunoglobulins showed avid binding, IgM giving the strongest reaction, followed by IgA and then IgG. Fc fragments of IgG gave binding, but F(ab')2 fragments from the three main Ig classes did not, s...

journal_title：Clinical and experimental immunology

authors： Pambakian S,Poston RN

更新日期：1987-05-01 00:00:00

abstract：:Experimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the effects of MHC and non-MHC genes on the development of EAU in the rat. EAU-susceptible LEW (RT1l), EAU-resistant WKAH (...

journal_title：Clinical and experimental immunology

authors： Hirose S,Ogasawara K,Natori T,Sasamoto Y,Ohno S,Matsuda H,Onoé K

更新日期：1991-12-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00

abstract：:An attempt was made to correlate lymphocyte subset abnormalities with the development of experimental autoimmune thyroiditis (EAIT) in thymectomized and irradiated rats of five inbred strains. The peripheral blood subpopulations were analysed using the fluorescence-activated cell sorter (FACS-IV). A significant lympho...

journal_title：Clinical and experimental immunology

authors： Smith E,Behan WM,Menzies CB,Behan PO

更新日期：1987-02-01 00:00:00

abstract：:Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...

journal_title：Clinical and experimental immunology

authors： Catalona WJ,Tarpley JL,Potvin C,Chretien PB

更新日期：1975-02-01 00:00:00

abstract：:The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

journal_title：Clinical and experimental immunology

authors： Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

更新日期：1979-10-01 00:00:00

abstract：:The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 w...

journal_title：Clinical and experimental immunology

authors： Sandmand M,Bruunsgaard H,Kemp K,Andersen-Ranberg K,Pedersen AN,Skinhøj P,Pedersen BK

更新日期：2002-01-01 00:00:00

abstract：:The number of CR1 on podocytes is reduced in nephropathies with severe glomerular damage, especially in the diffuse proliferative glomerulonephritis (DPGN) of systemic lupus erythematosus (SLE). Reduction of CR1 number on erythrocytes is due to proteolysis of CR1 by macrophage proteases activated by the reaction of th...

journal_title：Clinical and experimental immunology

authors： Teixeira JE,Costa RS,Lachmann PJ,Würzner R,Barbosa JE

更新日期：1996-09-01 00:00:00

abstract：:Tolerance to lipopolysaccharide (LPS) constitutes a stress adaptation, in which a primary contact with LPS results in a minimal response when a second exposure with the same stimulus occurs. However, active important defence mechanisms are mounted during the tolerant state. Our aim was to assess the contribution of po...

journal_title：Clinical and experimental immunology

authors： Landoni VI,Chiarella P,Martire-Greco D,Schierloh P,van-Rooijen N,Rearte B,Palermo MS,Isturiz MA,Fernández GC

更新日期：2012-04-01 00:00:00

abstract：:The objective of the study was to determine the diagnostic value for rheumatoid arthritis (RA) of anti-filaggrin autoantibodies (autoAb) recognizing citrullinated recombinant rat filaggrin (ACRF) in community cases of very early arthritis. To evaluate the diagnostic value of ACRF, were studied sera from patients with ...

journal_title：Clinical and experimental immunology

authors： Vittecoq O,Incaurgarat B,Jouen-Beades F,Legoedec J,Letourneur O,Rolland D,Gervasi G,Ménard JF,Gayet A,Fardellone P,Daragon A,Jolivet M,le Loët X,Tron F

更新日期：2004-01-01 00:00:00

abstract：:Conversion of arginyl to citrullyl residues (citrullination) is essential for the formation of the epitopes recognized by rheumatoid arthritis (RA)-associated autoantibodies to citrullinated proteins (ACPA). ACPA are secreted by plasma cells of the rheumatoid synovial tissue where their major target, citrullinated fib...

journal_title：Clinical and experimental immunology

authors： Duplan V,Foulquier C,Clavel C,Al Badine R,Serre G,Saoudi A,Sebbag M

更新日期：2006-09-01 00:00:00

abstract：:In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic...

journal_title：Clinical and experimental immunology

authors： Eckhardt J,Döbbeler M,König C,Kuczera K,Kuhnt C,Ostalecki C,Zinser E,Mak TW,Steinkasserer A,Lechmann M

更新日期：2015-07-01 00:00:00

abstract：:Type 1 IFN is thought to be implicated in the autoimmune process of SLE. Plasmacytoid dendric cells (DC), which are natural IFN-alpha producing cells, play a pivotal epipathogenic role in SLE. The present study was undertaken to investigate the phenotypic characteristics of peripheral blood DC in SLE patients in compa...

journal_title：Clinical and experimental immunology

authors： Migita K,Miyashita T,Maeda Y,Kimura H,Nakamura M,Yatsuhashi H,Ishibashi H,Eguchi K

更新日期：2005-10-01 00:00:00

abstract：:The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W (B/W) mice have been studied using a quantitative histological method. Injections with ND for 9 months, once every 3 weeks, starting at 4 weeks of age, reduced the ...

journal_title：Clinical and experimental immunology

authors： Schot LP,Verheul HA,Schuurs AH

更新日期：1984-09-01 00:00:00

abstract：:The success of pregnancy depends upon regulatory mechanisms that allow the fetus to survive and develop to term in the uterus, despite maternal immune cells' awareness of paternal alloantigens. At least some of these specific mechanisms are mediated by the effect of fetal trophoblast cells. In the present study we exa...

journal_title：Clinical and experimental immunology

authors： Talayev VY,Matveichev AV,Lomunova MA,Talayeva MV,Tsaturov ME,Zaichenko IY,Babaykina ON

更新日期：2010-10-01 00:00:00

abstract：:The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimul...

journal_title：Clinical and experimental immunology

authors： Noursadeghi M,Pepys MB,Gallimore R,Cohen J

更新日期：2005-04-01 00:00:00

abstract：:A solid phase radioimmunoassay, similar to the RAST, was developed in an attempt to predict anaphylactic reactions in patients injected with the proteolytic enzyme chymopapain, used in therapy for prolapsed intervertebral disc. The test measured the serum content of anti-chymopapain antibodies of the IgE class. Of 126...

journal_title：Clinical and experimental immunology

authors： Kapsalis AA,Stern IJ,Bornstein I

更新日期：1978-07-01 00:00:00

abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

journal_title：Clinical and experimental immunology

authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

更新日期：1979-11-01 00:00:00

abstract：:XLA bone marrow samples were shown to contain B cells expressing IgM, and pre-B cells that express the mu-surrogate light chain (mu psiLC) complex, albeit at a reduced frequency to that found in normal bone marrow. Antibody ligation of mu heavy chain on these cells and an XLA B cell line did not induce a Ca2+ flux, wh...

journal_title：Clinical and experimental immunology

authors： Genevier HC,Callard RE

更新日期：1997-12-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Binding of lymphocytes to human umbilical vein endothelial cells (EC) was quantitated by measuring adhesion of 51Cr labelled lymphocytes to endothelial cell monolayers and rosette formation between lymphocytes and EC in suspension. Mitogen stimulated human peripheral blood mononuclear cell culture supernatants and mix...

journal_title：Clinical and experimental immunology

authors： Yu CL,Haskard DO,Cavender D,Johnson AR,Ziff M

更新日期：1985-12-01 00:00:00

abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

journal_title：Clinical and experimental immunology

authors： Shiratsuchi H,Tsuyuguchi I

更新日期：1984-08-01 00:00:00

abstract：:The mycobacterial antigens and the factors related to protection for the development of active tuberculosis are not known. In a natural model of tuberculosis, we studied 10 patients with active pulmonary tuberculosis (non-protective immune response) and 38 healthy household contacts (protective immune response). We te...

journal_title：Clinical and experimental immunology

authors： Torres M,Mendez-Sampeiro P,Jimenez-Zamudio L,Teran L,Camarena A,Quezada R,Ramos E,Sada E

更新日期：1994-04-01 00:00:00

abstract：:Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormone, but exerts various effects on haematopoietic cells, embryos, and fibroblasts. In the present study we have examined effects of activin A on IgE synthesis and cytokine production by peripheral blood mononuclear cells (PBM...

journal_title：Clinical and experimental immunology

authors： Yamashita N,Nakajima T,Takahashi H,Kaneoka H,Mizushima Y,Sakane T

更新日期：1993-10-01 00:00:00

abstract：:Characterization of the Toll-like receptor (TLR) family and associated signalling pathways provides a key molecular basis for our understanding of the relationship between exposure to microbial products and susceptibility to immune-mediated disorders. Indeed, ligation of TLR controls innate and adaptive immune respons...

journal_title：Clinical and experimental immunology

authors： Goldman M

更新日期：2007-02-01 00:00:00

abstract：:To define the role of quantitative graft composition and donor killer-cell immunoglobulin-like receptor (KIR) genotype in clinical outcome following unmanipulated peripheral blood stem cell transplantation (PBSCT) from human leucocyte antigen (HLA)-identical siblings, 43 consecutive transplants for haematological mali...

journal_title：Clinical and experimental immunology

authors： Clausen J,Wolf D,Petzer AL,Gunsilius E,Schumacher P,Kircher B,Gastl G,Nachbaur D

更新日期：2007-06-01 00:00:00

abstract：:Parasite antigens released from Trypanosoma cruzi-infected cells were adsorbed to infected and uninfected mammalian cells thus rendering them susceptible to immune lysis by antibody and cell-mediated immunity directed against the parasite. BALB/c mice infected with T. cruzi for 15 days developed cytotoxic T lymphocyte...

journal_title：Clinical and experimental immunology

authors： Ribeiro Dos Santos R,Hudson L

更新日期：1980-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with aberrant activation of T and B lymphocytes for the production of inflammatory cytokines and autoreactive antibodies. Animal studies of SLE have indicated that Toll-like receptors (TLR) are important in the pathogenesis of murine lupus....

journal_title：Clinical and experimental immunology

authors： Wong CK,Wong PT,Tam LS,Li EK,Chen DP,Lam CW

更新日期：2010-01-01 00:00:00