Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis.


:In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic T helper type 1 (Th1) cells in the central nervous system (CNS) of TSLP KO mice. In addition, CD4(+) and CD8(+) T cells from CNS of TSLP KO mice show a reduced activation status in comparison to wild-type mice. It is noteworthy that we could also show that lymph node cells from TSLP KO mice expanded less efficiently and that interleukin (IL)-6-, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels were reduced. Furthermore, CD3(+) T cells isolated in the preclinical phase from myelin oligodendrocyte glycoprotein peptide 35-55 (MOG(35-55))-immunized TSLP KO mice showed a reduced response after secondary exposure to MOG(35-55), indicating that differentiation of naive T cells into MOG(35-55)-specific effector and memory T cells was impaired in KO mice. The addition of recombinant TSLP enhanced T cell proliferation during MOG(35-55) restimulation, showing that T cells also respond directly to TSLP. In summary, these data demonstrate that expression of, and immune activation by, TSLP contributes significantly to the immunopathology of EAE.


Clin Exp Immunol


Eckhardt J,Döbbeler M,König C,Kuczera K,Kuhnt C,Ostalecki C,Zinser E,Mak TW,Steinkasserer A,Lechmann M




Has Abstract


2015-07-01 00:00:00












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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Evengård B,Hammarström L,Smith CI,Johansson SG,Linder E

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  • Altered regulation of mitogen responsiveness by suppressor cells in multiple sclerosis.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Gonzalez RL,Dau PC,Spitler LE

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  • Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究


    authors: Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

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    authors: Borges M,Rosa GT,Appelberg R

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    authors: Dong Y,Liu F,Wu C,Li S,Zhao X,Zhang P,Jiao J,Yu X,Ji Y,Zhang M

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


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    authors: Lin YS,Lin CF,Fang YT,Kuo YM,Liao PC,Yeh TM,Hwa KY,Shieh CC,Yen JH,Wang HJ,Su IJ,Lei HY

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

    更新日期:1984-04-01 00:00:00

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Sasaki T,Shibata S,Hirabayashi Y,Sekiguchi Y,Yoshinaga K

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  • The role of anti-endothelial cell antibodies in Kawasaki disease - in vitro and in vivo studies.

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    authors: Grunebaum E,Blank M,Cohen S,Afek A,Kopolovic J,Meroni PL,Youinou P,Shoenfeld Y

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    pub_type: 杂志文章


    authors: Stopfer P,Obermeier F,Dunger N,Falk W,Farkas S,Janotta M,Möller A,Männel DN,Hehlgans T

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    authors: Therriault MJ,Proulx LI,Castonguay A,Bissonnette EY

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Schuit HR,Hijmans W,Asma GE

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    journal_title:Clinical and experimental immunology

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    authors: Mackiewicz A,Schultz D,Mathison J,Ganapathi M,Kushner I

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    authors: Hellema HW,Samuel T,Rumke P

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    journal_title:Clinical and experimental immunology

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Singh AK,Kasinath BS

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Bengtsson AA,Sturfelt G,Gullstrand B,Truedsson L

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Arfors L,Lefvert AK

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Oliver E,Pope C,Clarke E,Langton Hewer C,Ogunniyi AD,Paton JC,Mitchell T,Malley R,Finn A

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


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    更新日期:2006-01-01 00:00:00