当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Adoptive transfer of an autoimmunological labyrinthitis in the guinea pig; animal model for a sympathetic cochleolabyrinthitis.

Adoptive transfer of an autoimmunological labyrinthitis in the guinea pig; animal model for a sympathetic cochleolabyrinthitis.

Abstract：

:Sensorineural hearing loss is a common problem in the otolaryngologist's practice, with autoimmune disease of the inner ear being one possible cause. The restoration of auditory function in some patients following immunosuppressive therapy has created a desire to define and understand this disease better. Because of the lack of a well defined detection method to identify this entity clinically, this study was undertaken in order to provide an animal model for autoimmune disease of the inner ear. Previous studies with guinea pigs have demonstrated that sensitized lymphocytes from the systemic circulation migrate to the labyrinth during an immune response in the inner ear. The aim of this study was to prove the capacity of sensitized lymphocytes to transfer autoimmune inner ear disease, and to describe the resulting morphological and physiological changes. Therefore two groups of sensitized lymphocytes partially labelled with a radioactive marker from inbred guinea pigs with an immune response within the inner ear were injected into the bloodstream of naive recipient animals. Most of the labelled cells were observed in the apical turn of the experimental cochlea, while only few cells were detectable in the control cochleas. In addition, the absence of otoacoustic emissions and the loss of outer hair cells observed by electron microscopy were interpreted as a sign of damage caused by the provoked immunopathologic mechanism. The results are discussed as a possible model for a sympathetic cochleolabyrinthitis.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Gloddek B,Rogowski M,Reiss G,Arnold W

doi

10.1111/j.1365-2249.1994.tb06591.x

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

133-7

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

97

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians.

    abstract：:Increasing evidence has demonstrated that the immune system closely interacts with other physiological systems, whose communications are mediated by circulating cytokines and hormones. The aim of our study was to test whether the number and cytolytic activity of NK cells in a group of relatively healthy Italian nonage...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00855.x

    authors： Mariani E,Ravaglia G,Forti P,Meneghetti A,Tarozzi A,Maioli F,Boschi F,Pratelli L,Pizzoferrato A,Piras F,Facchini A

    更新日期：1999-04-01 00:00:00

  • The role of the immune system in kidney disease.

    abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13119

    authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

    更新日期：2018-05-01 00:00:00

  • Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis.

    abstract：:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of PR3-ANCA do not always correspond to clinical disease activity. To investigate the relationship between functional effects of...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01926.x

    authors： van der Geld YM,Tool AT,Videler J,de Haas M,Tervaert JW,Stegeman CA,Limburg PC,Kallenberg CG,Roos D

    更新日期：2002-09-01 00:00:00

  • Isolation and characterization of dendritic cells from adenoids of children with otitis media with effusion.

    abstract：:Dendritic cells were enriched from adenoids of children with otitis media with effusion (OME) by density gradient centrifugation and culture techniques. An enrichment of 40-140-fold was obtained for dendritic cells. These cells were identified using morphology, enzyme cytochemistry, immunocytochemistry and functional ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb03085.x

    authors： van Nieuwkerk EB,van der Baan S,Richters CD,Kamperdijk EW

    更新日期：1992-05-01 00:00:00

  • Purification of normal human eosinophils using the different binding capacities of blood leucocytes for complexed rabbit IgG.

    abstract：:A method has been developed for separating eosinophils from other types of leucocyte in normal individuals. Erythrocytes are sedimented with dextran, and mononuclear cells are removed on an isotonic density gradient of ficoll and sodium diatrizoate. The eosinophils and neutrophils are then washed and sedimented onto p...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Tai PC,Spry CJ

    更新日期：1977-05-01 00:00:00

  • Analysis of immunoglobulin G in multiple sclerosis brain: quantitative and isoelectric focusing studies.

    abstract：:Immunoglobulin G (IgG) in soluble and particulate fractions of discrete tissue samples from multiple sclerosis (MS) brain was analysed. Supernatant IgG/albumin rations and particulate-bound IgG levels were highest in samples dissected from MS plaques and adjacent white matter. Acid extracts of particulate fractions fr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Glynn P,Gilbert HM,Newcombe J,Cuzner ML

    更新日期：1982-04-01 00:00:00

  • Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1.

    abstract：:Lymphocytes from normal individuals with the histocompatibility antigens HLA-B8 and DR3 have impaired proliferative responses when stimulated with suboptimal concentrations of mitogens. We have previously shown that an important factor in the impaired response is a failure to produce normal quantities of interleukin-2...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05183.x

    authors： Hashimoto S,Michalski JP,Berman MA,McCombs C

    更新日期：1990-02-01 00:00:00

  • Anti-atherogenic peptide Ep1.B derived from apolipoprotein E induces tolerogenic plasmacytoid dendritic cells.

    abstract：:Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12370

    authors： Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

    更新日期：2014-09-01 00:00:00

  • Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients.

    abstract：:Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06123.x

    authors： Jaleco AC,Covas MJ,Victorino RM

    更新日期：1994-11-01 00:00:00

  • Increased frequency of skin-infiltrating FoxP3+ regulatory T cells as a diagnostic indicator of severe atopic dermatitis from cutaneous T cell lymphoma.

    abstract：:Differential diagnosis of cutaneous T cell lymphoma (CTCL) and severe atopic dermatitis (AD) is often difficult because of the similarity in their skin manifestations. However, such differentiation is extremely important because of the differences in remedy and prognosis. The aim of this study was to investigate new, ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12073

    authors： Hanafusa T,Matsui S,Murota H,Tani M,Igawa K,Katayama I

    更新日期：2013-06-01 00:00:00

  • The binding of immunoglobulin Fc to cationic proteins.

    abstract：:The interaction of cationic proteins with IgG, IgA and IgM were investigated by solid phase radioimmunoassay. All these immunoglobulins showed avid binding, IgM giving the strongest reaction, followed by IgA and then IgG. Fc fragments of IgG gave binding, but F(ab')2 fragments from the three main Ig classes did not, s...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Pambakian S,Poston RN

    更新日期：1987-05-01 00:00:00

  • Interleukin-2 activated peripheral blood lymphocytes and the correlation of lytic activity and peanut agglutinin receptor expression on malignant cells.

    abstract：:The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensiti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gotoh YI,Minegishi M,Yamaguchi Y,Konno T,Tada K

    更新日期：1984-09-01 00:00:00

  • Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes.

    abstract：:Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise destruction of a single endocrine cell type occurring on a distinct genetic and autoimmune background - have been unravelled in recent years to such an extent tha...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2007.03328.x

    authors： Staeva-Vieira T,Peakman M,von Herrath M

    更新日期：2007-04-01 00:00:00

  • IgD production and other lymphocyte functions in HIV infection: immaturity and activation of B cells at different clinical stages.

    abstract：:T and B cell function, in particular IgD production in vitro, were studied across the spectrum of HIV infection in homosexual men and compared with seronegative homosexual and heterosexual male controls. Proliferation to phytohaemagglutinin (PHA) was reduced most strikingly in symptomatic HIV infection; it was also im...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rogers LA,Forster SM,Pinching AJ

    更新日期：1989-01-01 00:00:00

  • The paraproteins in systemic capillary leak syndrome.

    abstract：:Systemic capillary leak syndrome (SCLS) is a rare disease characterized by episodes of collapse due to rapid transfer of considerable volumes of plasma from the intravascular to the extravascular compartment. The pathogenesis of this disease is unknown. The diagnosis is made largely on clinical grounds, and investigat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb08195.x

    authors： Zhang W,Ewan PW,Lachmann PJ

    更新日期：1993-09-01 00:00:00

  • Long-term human immune system reconstitution in non-obese diabetic (NOD)-Rag (-)-γ chain (-) (NRG) mice is similar but not identical to the original stem cell donor.

    abstract：:The murine immune system is not necessarily identical to it human counterpart, which has led to the construction of humanized mice. The current study analysed whether or not a human immune system contained within the non-obese diabetic (NOD)-Rag1(null) -γ chain(null) (NRG) mouse model was an accurate representation of...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12192

    authors： Harris DT,Badowski M,Balamurugan A,Yang OO

    更新日期：2013-12-01 00:00:00

  • Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy.

    abstract：:A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05721.x

    authors： Duncan JI,Horrocks C,Ormerod AD,Powles AV,Whiting PH,Fry L,Thomson AW

    更新日期：1991-08-01 00:00:00

  • Phagocytosis of apoptotic cells by macrophages in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis.

    abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It is not known why ANCA develop, but it has been shown that they participate in pathogenesis by activating polymorphonuclear n...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2012.04633.x

    authors： Ohlsson SM,Pettersson Å,Ohlsson S,Selga D,Bengtsson AA,Segelmark M,Hellmark T

    更新日期：2012-10-01 00:00:00

  • Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12.

    abstract：:Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01943.x

    authors： Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

    更新日期：2002-10-01 00:00:00

  • IgE rheumatoid factors: quantification in synovial fluid and ability to induce synovial mast cell histamine release.

    abstract：:IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten control samples. Synovial fluid IgE RF activity was higher than predicted by diffusion alone in 7/11 (64%) of the RA syn...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gruber B,Ballan D,Gorevic PD

    更新日期：1988-02-01 00:00:00

  • IL-4 and transforming growth factor-beta suppress human immunoglobulin secretion in vitro by surface IgD- B cells.

    abstract：:The effect of IL-4 and transforming growth factor-beta (TGF-beta) on immunoglobulin secretion in vitro by peripheral blood mononuclear cells (PBMC) or purified B cells activated with murine EL4 thymoma cells and phorbol myristate acetate (PMA) was investigated. As previously reported, IL-4 induced IgE and IgG4 secreti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06942.x

    authors： Ninomiya C,Spiegelberg HL

    更新日期：1992-08-01 00:00:00

  • Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells.

    abstract：:The clinical use of dendritic cells (DCs) to induce antigen-specific immune tolerance has been hampered by the lack of a widely acknowledged method for generating human regulatory DCs but even more so by the non-existence of reliable markers. Thus, we set out to find reliable markers that can be measured with simple m...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2009.03961.x

    authors： Pedersen AW,Holmstrøm K,Jensen SS,Fuchs D,Rasmussen S,Kvistborg P,Claesson MH,Zocca MB

    更新日期：2009-07-01 00:00:00

  • Amyloid fibril protein AA in Papua New Guinean amyloidosis.

    abstract：:In this study of protein composition of amyloid fibrils isolated from eight patients representative of the spectrum of amyloidosis found in Papua New Guinea has been investigated. All fibril preparations, including three from patients with amyloidosis secondary to lepromatous leprosy and one from an unusual juvenile c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Anders RF,Price MA,Wilkey IS,Husby G,Takitaki F,Natvig JB,McAdam KP

    更新日期：1976-04-01 00:00:00

  • Streptococci and Actinomyces induce antibodies which cross react with epithelial antigens in periodontitis.

    abstract：:Perturbation of epithelial structure is a prominent but poorly understood feature of the immunopathological response to bacterial antigens which characterizes the destructive lesion of periodontitis. Western analysis of sera from 22 patients with periodontitis detected multiple antigens in extracts of epithelial cells...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02088.x

    authors： Ye P,Harty DW,Chapple CC,Nadkarni MA,Carlo AA,Hunter N

    更新日期：2003-03-01 00:00:00

  • Defective antigen presentation by lavage cells from terminal patients with cystic fibrosis.

    abstract：:Macrophages separated from lavage samples obtained from lungs removed at transplantation from patients with cystic fibrosis (CF) and other lung diseases, have been compared with circulating monocytes from the same patients for their ability to stimulate allogeneic normal circulating lymphocytes and to present antigen ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.d01-954.x

    authors： Knight RA,Kollnberger S,Madden B,Yacoub M,Hodson ME

    更新日期：1997-03-01 00:00:00

  • Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update.

    abstract：:Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among d...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2011.04461.x

    authors： de Vries E,European Society for Immunodeficiencies (ESID) members.

    更新日期：2012-01-01 00:00:00

  • T cell receptor gamma delta bearing cells are decreased in the peripheral blood of patients with atopic diseases.

    abstract：:The biological role of T cell receptor (TCR) gamma delta bearing cells is currently not fully understood. Recently, a monoclonal antibody (TCR delta 1) reacting against the whole molecule became available which facilitates the direct analysis of TCR-gamma delta+ cells. We studied 11 children with atopic dermatitis, 20...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb02950.x

    authors： Schauer U,Dippel E,Gieler U,Bräuer J,Jung T,Heymanns J,Rieger CH

    更新日期：1991-12-01 00:00:00

  • Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

    abstract：:Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further beg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2008.03704.x

    authors： Dubois PC,van Heel DA

    更新日期：2008-08-01 00:00:00

  • Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigens recognized by HIV-, CMV+ individuals.

    abstract：:In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05490.x

    authors： Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

    更新日期：1990-12-01 00:00:00

  • Correlations among cutaneous reactivity to DNCB, PHA-induced lymphocyte blastogenesis and peripheral blood E rosettes.

    abstract：:Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Catalona WJ,Tarpley JL,Potvin C,Chretien PB

    更新日期：1975-02-01 00:00:00