Amyloid fibril protein AA in Papua New Guinean amyloidosis.

Abstract:

:In this study of protein composition of amyloid fibrils isolated from eight patients representative of the spectrum of amyloidosis found in Papua New Guinea has been investigated. All fibril preparations, including three from patients with amyloidosis secondary to lepromatous leprosy and one from an unusual juvenile case of primary amyloidosis, contained the non-immunogobulin amyloid protein, protein AA. However, only 44% of thirty-six amyloid patients had detectable levels of the protein AA-related serum component, protein SAA. Alkali-degraded material from each of the fibril preparations failed to react in double immunodiffusion test with antiserum to the amyloid-related light chain VgammaV, but evidence was found for this immunoglobulin light chain-specificity in the serum of one patient.

journal_name

Clin Exp Immunol

authors

Anders RF,Price MA,Wilkey IS,Husby G,Takitaki F,Natvig JB,McAdam KP

subject

Has Abstract

pub_date

1976-04-01 00:00:00

pages

49-53

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

24

pub_type

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