Defective antigen presentation by lavage cells from terminal patients with cystic fibrosis.

abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

journal_title：Clinical and experimental immunology

authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

更新日期：2005-07-01 00:00:00

abstract：:Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both a...

journal_title：Clinical and experimental immunology

authors： Tooze JA,Bevan DH

更新日期：1991-03-01 00:00:00

abstract：:There have been many studies on the mechanisms of internalization of DNA-anti-DNA immune complexes by cells, including the one used for rheumatoid factor-expressing mouse B cells. In parallel, studies on the role of intracellular DNA sensors in the pathogenesis of systemic lupus erythematosus (SLE) have been conducted...

journal_title：Clinical and experimental immunology

authors： Inoue K,Ishizawa M,Kubota T

更新日期：2020-02-01 00:00:00

abstract：:Morbidity and mortality in cystic fibrosis (CF) is predominantly due to destruction of pulmonary tissue. The host immune response may, in part, play a pathogenic role in pulmonary destruction in these patients. To further understand host immune response in CF, we examined the state of activation of peripheral blood mo...

journal_title：Clinical and experimental immunology

authors： Jones MM,Seilheimer DK,Pier GB,Rossen RD

更新日期：1990-06-01 00:00:00

abstract：:Plasma exchange (PE) and ex vivo immunoadsorption (IA) may be applicable to the removal of anti-insulin antibodies (AI-Ab) from diabetic patients. However, the removal of antibodies may prompt an increase in their rate of synthesis and an overshoot of antibody levels which may be deleterious to the patient. The effect...

journal_title：Clinical and experimental immunology

authors： Charlton B,Antony G,Cooper SG,Schindhelm K

更新日期：1988-05-01 00:00:00

abstract：:Cyclosporin (CsA) is widely used in the treatment of renal disease and transplantation, which are often complicated by alterations of lipid metabolism. Both chronic administration of CsA and hyperlipidaemia have been shown to evoke an early macrophage influx and have progressively led to glomerular and interstitial sc...

journal_title：Clinical and experimental immunology

authors： Di Paolo S,Grandaliano G,Gesualdo L,Ranieri E,Schena FP

更新日期：1999-08-01 00:00:00

abstract：:We have produced monoclonal antibodies (MoAb) to the Rb core and lipid A regions of Salmonella lipopolysaccharide (LPS) and have assessed their ability to inhibit LPS-mediated mitogenic responses in vitro, and to protect against LPS toxicity and lethal Salmonella infection in vivo. Monoclonal antibodies RC-8 and RC-16...

journal_title：Clinical and experimental immunology

authors： Ward DC,Michalek SM,McGhee JR

更新日期：1988-04-01 00:00:00

abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

journal_title：Clinical and experimental immunology

authors： Zanetti M,Bellon B,Verroust P,Druet P

更新日期：1980-10-01 00:00:00

abstract：:Natural autoantibodies (NaAb) and IgG antibodies to tetanus toxoid (TT) were analysed in the sera of 38 children with active visceral leishmaniasis (VL) previously vaccinated with TT and in 30 healthy controls matched for sex and age. Patients exhibited high levels of NaAb to a panel of self antigens (tubulin, myosin,...

journal_title：Clinical and experimental immunology

authors： Louzir H,Belal-Kacemi L,Sassi A,Laouini D,Ben Ismail R,Dellagi K

更新日期：1994-03-01 00:00:00

abstract：:We report a study on immunoregulation of in vitro antibody to hepatitis B surface antigen (anti-HBs) synthesis induced by pokeweed mitogen (PWM) from peripheral blood mononuclear cells (PBMC) in chronic hepatitis B surface antigen (HBsAg) carriers and in 'high responders', (anti-HBs RIA ratio greater than or equal to ...

journal_title：Clinical and experimental immunology

authors： Barnaba V,Valesini G,Levrero M,Zaccari C,Van Dyke A,Falco M,Musca A,Balsano F

更新日期：1985-05-01 00:00:00

abstract：:HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. A...

journal_title：Clinical and experimental immunology

authors： Boswell MT,Rowland-Jones SL

更新日期：2019-06-01 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

journal_title：Clinical and experimental immunology

authors： Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

更新日期：2014-09-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:Induction of allograft tolerance has been considered the ultimate goal in organ transplantation. Although numerous protocols to induce allograft tolerance have been reported in mice, a chimerism-based approach through donor haematopoietic stem cell transplantation has been the only approach to date that induced allogr...

journal_title：Clinical and experimental immunology

authors： Oura T,Cosimi AB,Kawai T

更新日期：2017-08-01 00:00:00

abstract：:There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity w...

journal_title：Clinical and experimental immunology

authors： Fenoy I,Giovannoni M,Batalla E,Martin V,Frank FM,Piazzon I,Goldman A

更新日期：2009-02-01 00:00:00

abstract：:An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

journal_title：Clinical and experimental immunology

authors： Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

更新日期：1997-11-01 00:00:00

abstract：:Serum factors activating the alternative pathway of complement in vitro, independent of classical pathway activation was demonstrated in six of eleven patients with systemic lupus erythematosus (SLE). These serum factors were detected by lysis of gluthathione-sensitized human erythrocytes and by C3 and factor B conver...

journal_title：Clinical and experimental immunology

authors： Wilson MR,Arroyave CM,Nakamura RM,Vaughan JH,Tan EM

更新日期：1976-10-01 00:00:00

abstract：:IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin solid phase assays in both HBsAg+ and HBsAg- groups of patients with primary hepatocellular carcinoma (HCC). No differences were observed between the two patient groups either in the levels of ant...

journal_title：Clinical and experimental immunology

authors： Brown SE,Howard CR,Steward MW,Ajdukiewicz AB,Whittle HC

更新日期：1984-02-01 00:00:00

abstract：:Human thymoma is a thymic epithelial cell tumour which often contains a large number of immature T cells and is frequently associated with autoimmune diseases. Since thymic epithelial cells play key roles in the development and selection of T cells in the normal thymus, we hypothesized that the neoplastic thymic epith...

journal_title：Clinical and experimental immunology

authors： Inoue M,Fujii Y,Okumura M,Takeuchi Y,Shiono H,Miyoshi S,Matsuda H,Shirakura R

更新日期：1998-06-01 00:00:00

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses. T cell activation requires both Af-specific engagement of the T-cell-receptor as well as interaction of antigen indepe...

journal_title：Clinical and experimental immunology

authors： Barrios CS,Johnson BD,D Henderson J Jr,Fink JN,Kelly KJ,Kurup VP

更新日期：2005-11-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships...

journal_title：Clinical and experimental immunology

authors： Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

更新日期：2013-03-01 00:00:00

abstract：:The spontaneous lysis of target cells sensitive to natural killer (NK) activity is accomplished in two distinct phases: (i) binding between target and effector cells and (ii) post-binding events leading to target cell destruction. To test the hypothesis that cell surface carbohydrate(s) might be involved in recognitiv...

journal_title：Clinical and experimental immunology

authors： Vose BM,Harding M,White W,Moore M,Gallagher J

更新日期：1983-03-01 00:00:00

abstract：:The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or alpha M beta 2 (complement receptor type 3 = CR3). In the present study...

journal_title：Clinical and experimental immunology

authors： Palmen MJ,Dijkstra CD,van der Ende MB,Peña AS,van Rees EP

更新日期：1995-08-01 00:00:00

abstract：:Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizyg...

journal_title：Clinical and experimental immunology

authors： Fyfe A,Holme ER,McKay IC,Zoma A,Hunter J,Lucie NP,Whaley K

更新日期：1987-10-01 00:00:00

abstract：:Endogenous retrovirus-3 (ERV-3) is an endogenous retrovirus encoding an open reading frame for an envelope protein expressed in placenta. In this study we also found high levels of expression in fetal heart, with peak expression occurring between 11 and 17 weeks of gestation. Antibodies to a peptide corresponding to a...

journal_title：Clinical and experimental immunology

authors： Li JM,Fan WS,Horsfall AC,Anderson AC,Rigby S,Larsson E,Venables PJ

更新日期：1996-06-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:Three B cell hybridomas were produced by the fusion of spleen cells from a 5 month old MRL/Mp-lpr/lpr mouse with the myeloma cell line, NS-1. By competitive inhibition, all three monoclonal antibodies (MoAb) were specific for poly(rA) and were inhibited to a lesser extent by dDNA, nDNA, poly(rI) and poly(rC). Moreover...

journal_title：Clinical and experimental immunology

authors： Dang H,Fischbach M,Erdos M,Talal N

更新日期：1985-07-01 00:00:00

abstract：:Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed ...

journal_title：Clinical and experimental immunology

authors： Dietz WH Jr,Porcell O,Moon TE,Peters CJ,Purcell RH

更新日期：1976-01-01 00:00:00